neurons – Communicable Diseases Research

Activation of Interferon-Stimulated Genes following Varicella-Zoster Virus Infection in a Human iPSC-Derived Neuronal In Vitro Model Depends on Exogenous Interferon-α

Article

Published on 2022-11-142023-05-31
Journal: Viruses
[Category] 두창, 수두, 홍역,

SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir

Article

Published on 2022-11-032022-11-15
Journal: PLoS Biology
[Category] SARS, 치료제,

Molecular diversity and phenotypic pleiotropy of ancient genomic regulatory loci derived from human endogenous retrovirus type H (HERVH) promoter LTR7 and HERVK promoter LTR5_Hs and their contemporary impacts on pathophysiology of Modern Humans

Article

Published on 2022-11-012022-11-15
Journal: Molecular genetics and genomics : MGG
[Category] SARS, 유전자 메커니즘, 진단,

[키워드] affected analysis Ape apes azoospermia Brain brain regions Cancer Cell cell type cells Central nervous system cognitive Consensus conserved coronavirus COVID-19 COVID-19 pandemic database defined disorders DNA sequence dominant element embryogenesis event Evidence Evolution expressed expression fetal functional gene signature Genes genes encoding Genome genomic germline global pandemic Glutamatergic GSEA HERV HERVs Human human cell Human embryogenesis human endogenous retrovirus Human endogenous retrovirus type H (HERVH) Human endogenous retrovirus type K (HERVK) human physiology Human spermatogenesis identification Impact implicated include Infection inheritance insertion Interaction Lineage loci LTR LTR5_Hs LTR7 subfamilies majority mammalian Mammalian offspring survival genes marker Metastasis Monkey morphological feature morphologically MOS naïve neoplasm Neoplasm metastasis Neural Neuron neurons New World non-human primates observation offspring Oligospermia pathogen pathology pathophysiology Phenotypes phenotypic physiological Pleiotropy Population population-level effect primate Primate evolution promoter protein-protein interaction Protein–protein interactions at synapses proteomics Quantitative Radial rare disease recessive regulated Regulatory regulatory element regulatory sequence Release replicate representing Retrotransposition retroviral retrovirus SARS-CoV-2 SARS-CoV-2 coronavirus Schizophrenia sequence significantly Spread Stage survival synaptic Synaptic transmission Synaptic transmission. target the SARS-CoV-2 timeline traits Transmission trigeminal undergo viral genome viral infection viral infections virus viruses
[DOI] 10.1007/s00438-022-01954-7 PMC 바로가기

Morphological, cellular, and molecular basis of brain infection in COVID-19 patients

코로나19 환자 뇌 감염의 형태적, 세포적, 분자적 기초

Article

Published on 2022-08-302022-09-11
Journal: Proceedings of the National Academy of Sciences of
[Category] SARS, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration anxiety symptoms Astrocyte astrocytes biogenesis Brain brain damage Brain infection brain tissue brains cellular changes in characterized Cohort contribute coronavirus cortical Cortical atrophy COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients death deregulated died dysfunction elicit energy metabolism Evidence exhibited fatigue FIVE foci functional genetic material guide histopathological sign histopathological signs Hypothesis impairment in vitro independent individual infect infected individual Infection Interaction manifestation manifested mechanism metabolism metabolite metabolites mild infection molecular basis neural stem cell Neurological symptoms neurological symptoms. neuronal neurons Neuropsychiatric Neurotransmitters NRP1 Patient phenotype Protein reduce Replication SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Severe COVID-19 Infection Spectrum Support Supporting susceptible syndrome tissue sample viability virus
[DOI] 10.1073/pnas.2200960119 PMC 바로가기 [Article Type] Article

Role of aging in Blood-Brain Barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19

혈액-뇌장벽 기능 장애 및 SARS-CoV-2 감염에 대한 감수성에서 노화의 역할: COVID-19의 신경학적 증상에 대한 영향

Review

Published on 2022-08-182022-09-11
Journal: Fluids and Barriers of the CNS
[Category] SARS, 치료기술, 치료제,

[키워드] addition age aging alleviate astrocytes barrier blood-brain barrier Brain caused cell type Central nervous system cerebrospinal fluid CNS Comorbidity Corona Corona virus COVID-19 COVID-19 patients Cytokine storm deaths described diabete diabetes distress dysfunction endothelial cells endothelial function expression profile Hospitalization Impact inducer inflammatory reaction inflammatory reactions Interaction interactome microglia Mitochondria mitochondrial Mitochondrial function mitochondrial functions morbidity and mortality neurological Neurological symptom Neurological symptoms neurons Neurovascular outcome patients pericytes Pneumonia present respiratory respiratory distress risk factor role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 receptors Severe acute respiratory syndrome Severe Acute Respiratory Syndrome Corona Virus suggested susceptibility target therapy treat with COVID-19
[DOI] 10.1186/s12987-022-00357-5 PMC 바로가기 [Article Type] Review

Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease

Research

Published on 2022-08-162022-10-05
Journal: Nature Communications
[Category] 유전자 메커니즘, 진단, 치료기술,

Deregulation of ceRNA Networks in Frontal Cortex and Choroid Plexus of Brain during SARS-CoV-2 Infection Aggravates Neurological Manifestations: An Insight from Bulk and Single-Cell Transcriptomic Analyses

SARS-CoV-2 감염 중 뇌의 전두엽 피질 및 맥락총 신경총에서 ceRNA 네트워크의 규제 완화는 신경 증상을 악화시킵니다: 대량 및 단일 세포 전사체 분석의 통찰력

Article

Published on 2022-08-012022-09-11
Journal: Advanced Biology
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] analysis analyzed Brain cell type cell types choroid Choroid plexus competing competing endogenous RNA network cortex deregulated differentially expressed downregulated downregulation downstream excitatory explain Frontal Gene Expression help Human brain impairment indicated Initially insight landscape lncRNA MALAT1 mapping mechanism MIRLET7BHG miRNA miRNA. miRNAs mRNA NEAT1 network neurological Neuron neurons NorAD pathway enrichment Plexus reconstructed regulatory circuit RNA RNA-Seq SARS-CoV-2 single-cell RNA-seq STXBP5 STXBP5-AS1 therapeutic Therapeutics transcriptomic upregulated upregulation Variability
[DOI] 10.1002/adbi.202101310 PMC 바로가기 [Article Type] Article

Chronological brain lesions after SARS-CoV-2 infection in hACE2-transgenic mice

hACE2 형질전환 마우스에서 SARS-CoV-2 감염 후 시간적 뇌 병변

Article

Published on 2022-07-012022-09-11
Journal: Veterinary pathology
[Category] COVID19(2023년), SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect Analysis animal model astrogliosis Beta Brain cause Central nervous system Cerebellum characterized coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 develop different time points distribution Encephalitis hACE2 hACE2-transgenic mice histopathological immunohistochemistry immunolabeling inoculation lesion meningoencephalitis mice mucosa necropsies necropsy Neuroinflammation Neurological disease neuronal neurons Neuropathology neuropathology. nonsuppurative olfactory other organ other organs panel of antibodies panel of antibody performed post inoculation processed question reached Respiratory disease SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 lineage SARS-CoV-2 neuroinvasion severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spongiosis Spread susceptible thrombosis transgenic mice vacuolar vacuolar degeneration variants Vasculitis virological assay virological assays virus
[DOI] 10.1177/03009858211066841 PMC 바로가기 [Article Type] Article

A highly photostable and bright green fluorescent protein

광안정성이 높고 밝은 녹색 형광 단백질

Article

Published on 2022-07-012022-09-11
Journal: Nature biotechnology
[Category] Fulltext, MERS, 변종,

K18- and CAG-hACE2 Transgenic Mouse Models and SARS-CoV-2: Implications for Neurodegeneration Research

K18- 및 CAG-hACE2 형질전환 마우스 모델 및 SARS-CoV-2: 신경변성 연구에 대한 시사점

Review

Published on 2022-06-282022-09-11
Journal: Molecules
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] absence ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral drug Autopsy Brain brain regions brain tissue CAG-hACE2 transgenic mice caused cells Central nervous system Confusion Consequences coronavirus COVID-19 COVID-19 patient COVID-19 patients Cytokines demonstrated develop direct infection disorder disorders dissect Encephalitis entry receptor enzyme evaluate glial cell global pandemic hACE2 helping human Angiotensin-converting enzyme Human brain increase in infected with SARS-CoV-2 Inflammation K18 K18-transgenic mice leukocyte leukocyte infiltration life manifestation mechanism Meningitis Mental Model molecular mouse Mouse models mucosa neuroinvasion. neurological Neurological complication Neurological complications neuronal neurons olfactory Patient periphery pro-inflammatory cytokine pro-inflammatory cytokines provoke Quality of life reported responses robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neuroinvasion severe acute respiratory syndrome Coronavirus suggested survivor therapy transgenic Transgenic mouse Vaccine development
[DOI] 10.3390/molecules27134142 PMC 바로가기 [Article Type] Review