In vitro and in vivo differences in neurovirulence between D614G, Delta And Omicron BA.1 SARS-CoV-2 variantsArticle Published on 2022-09-052022-11-16 Journal: Acta Neuropathologica Communications [Category] SARS, 변종, [키워드] acute phase acute respiratory syndrome astrocytes B.1.1.529 B.1.617.2 Brain olfactory bulb Cell CNS co-cultured coronavirus cortical COVID-19 Culture D614G days post infection Delta hamster hamsters in vitro in vivo in vivo models Infection inoculated interferon isolate mechanism microglia activation mucosa Neuroinflammation neuroinvasion Neuroinvasive Neurological complications Neuron neurotropic neurotropism neurovirulence neurovirulent occur olfactory omicron performed reduced SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2. shown the SARS-CoV-2 variant [DOI] 10.1186/s40478-022-01426-4 PMC 바로가기
Neurological Complications of Dengue Fever뎅기열의 신경학적 합병증Review Published on 2022-08-012022-09-12 Journal: Current neurology and neuroscience reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Acute disseminated encephalomyelitis antibody Antibody-dependent enhancement Autoimmune blood vessel cause Cell Central nervous system characterized CNS Coagulopathy Complication Course cranial cytokine release Dengue Dengue fever Dengue hemorrhagic fever Dengue shock syndrome dengue virus described develop Diagnosis differential diagnosis dysregulated Encephalitis Encephalopathy Epidemiology febrile hemorrhages Hemorrhagic Hemorrhagic Stroke Immune-mediated imperative implicated include increasingly infect Infection Inflammatory Injury Involvement Ischemic Isolated manifestation mechanism molecular nervous system Neural neurological Neurological complication Neurological complications of dengue. neuromuscular weakness neurotropic nuclei occur ocular paralysis Pathogenesis Patient plasma Posterior recent renal resulting SARS-CoV2 infection screened serotype Shock syndrome the disease treated Vasculitis virus [DOI] 10.1007/s11910-022-01213-7 PMC 바로가기 [Article Type] Review
COVID-19 and Postural Control—A Stabilographic Study Using Rambling-Trembling Decomposition MethodArticle Published on 2022-02-172022-10-30 Journal: Medicina [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] acute respiratory syndrome addition Analysis changes in conducted convalescent coronavirus coronavirus disease COVID-19 decomposition demonstrated distress Dyspnea enrolled evaluate eye globe healthy control Infection less material monitoring neurological neurotropic objective olfactory dysfunction platform postural control rambling-trembling Range Registered reported respiratory virus Result SARS-CoV-2 significant increase significantly increased stabilography stabilometry subject Symptom was performed [DOI] 10.3390/medicina58020305 PMC 바로가기 [Article Type] Article
Neurogenesis and Viral InfectionImmunology Published on 2022-02-172022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] Activation acute respiratory syndrome Affect animal models Brain Cell cell cycle progression cell death cells Central nervous system coronavirus cortical disease Evidence extrinsic fetal gliogenesis impairment Infection Invasion Local mammalian nervous system neural stem cell neural stem cells Neurogenesis neurological Neuron neurotropic SARS-CoV-2 stem cell Support Zika virus ZIKV [DOI] 10.3389/fimmu.2022.826091 PMC 바로가기 [Article Type] Immunology
Evidence of Microglial Immune Response Following Coronavirus PHEV Infection of CNSImmunology Published on 2022-01-102022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, [키워드] absence activated Activation Blood Brain cause Central nervous system circulating clearance CNS coronavirus dysfunction early stage Evidence evidence of Host Immune cell in vitro indicated induce Infection infiltration Invasion Macrophage mice microglia microglial monocyte/macrophage monocytes/macrophage neurological Neurological symptoms neurotropic porcine hemagglutinating encephalomyelitis virus Proinflammatory cytokine Proinflammatory response proliferation response responsible viral replication virus [DOI] 10.3389/fimmu.2021.804625 PMC 바로가기 [Article Type] Immunology
The Betacoronavirus PHEV Replicates and Disrupts the Respiratory Epithelia and Upregulates Key Pattern Recognition Receptor Genes and Downstream Mediators, Including IL-8 and IFN-λResearch Article Published on 2021-12-222022-10-30 Journal: mSphere [Category] Coronavirus, [키워드] Air-liquid interface airway epithelium ALI-REC Alpha Antiviral basal cells Betacoronavirus CCL2 CCL5 Cell culture cell cultures cells change chemokine chemokines ciliated cells coronavirus Culture CXCL10 CXCL8 Cytokines cytopathic disease Donor driving epithelia epithelial lining evaluated expression expression level Gene Expression goblet cells homeostasis IFN-λ1 IFN-stimulated gene IFN-λ IFN-λ1 IL-1β IL-6 IL-8 in vitro in vivo Including Increased infect Infection innate immune gene innate immune response Innate immunity innate response interleukin-1β investigated modulation molecular mechanism morphologically Necrosis Neonatal neurotropic OAS1 outcome pattern PHEV primary site Proinflammatory cytokine proliferative Recognition replicate replicated respiratory respiratory epithelia respiratory epithelial cell resulting RIG Stat1 tissue TLR TLR3 TLR7 TNF-α tracheal transcription factor Transcriptional upregulation triggered turn upper respiratory tract upregulation virus vomiting [DOI] 10.1128/mSphere.00820-21 PMC 바로가기 [Article Type] Research Article
The Causes and Long-Term Consequences of Viral EncephalitisNeuroscience Published on 2021-11-302022-10-31 Journal: Frontiers in Cellular Neuroscience [Category] COVID-19, [키워드] Affect affected astrocytes Autoimmune disease Brain cause Cell Central nervous system clinical symptom Cognitive impairment Coma Confusion consequence contributing to Coronaviruses degenerative described Diseases disorders Encephalitis Fever Frequency headache herpesviruses Immune cell infiltration impairment individual induce Inflammation local immune response microglia Mild morbidity and mortality neurons Neuropsychiatric neurotropic pathology pediatric populations pro-inflammatory molecule public health report reported secretion Seizures shown subsequent viral clearance viral encephalitis viral infection viral infections virus virus weakness zone [DOI] 10.3389/fncel.2021.755875 PMC 바로가기 [Article Type] Neuroscience
Occurrence of Guillain-Barre Syndrome During the Initial Symptomatic Phase of COVID-19 Disease: Coincidence or Consequence?Internal Medicine Published on 2021-11-172022-10-31 Journal: Cureus [Category] COVID-19, [키워드] Characteristics coincidence coronavirus COVID-19 Dysphagia Guillain Barre syndrome Guillain-barrè syndrome human immunoglobulin induce infected with SARS-CoV-2 Infection Inflammatory intravenous manifested molecular Multiple neurotropic neurotropic virus Patient phase shown Treatment viral infections viral mimicry virus [DOI] 10.7759/cureus.19655 PMC 바로가기 [Article Type] Internal Medicine
Intrathecal inflammatory responses in the absence of SARS-CoV-2 nucleic acid in the CSF of COVID-19 hospitalized patientsCOVID-19 입원 환자의 뇌척수액에서 SARS-CoV-2 핵산이 없을 때 척수강내 염증 반응Article Published on 2021-11-152022-09-11 Journal: Journal of the neurological sciences [Category] SARS, 변종, 치료기술, [키워드] absence acute COVID-19 albumin associations Atypical Blood Blood brain barrier cell count cerebrospinal fluid chemokine chemokines consecutive patient Control correlated COVID-19 COVID-19 patient COVID-19 patients Cryptococcus neoformans CSF Cytokines detectable evidence of healthy control HIV HIV-1 hospitalized patient IL-15 IL-6 IL-8 Infection Inflammation Inflammatory cytokine Inflammatory cytokines Inflammatory response inhibitory Intrathecal marker MCP-1 metagenomic sequencing MIP-1β monocyte Neurological symptom Neurological symptoms NEUROLOGY neurotropic pathogen Pathogens Patient patients patients with COVID-19 performed pleocytosis profile proinflammatory Proinflammatory cytokine proinflammatory cytokines Protein Quantitative reverse transcription PCR RT-qPCR SARS-CoV-2 nucleic acid SARS-CoV-2 RNA Sequencing sequencing. subset suppressed two patients was tested were infected West Nile Virus White blood cell with COVID-19 [DOI] 10.1016/j.jns.2021.120023 PMC 바로가기 [Article Type] Article
Functionalized Nanoparticles in Prevention and Targeted Therapy of Viral Diseases With Neurotropism Properties, Special Insight on COVID-19Microbiology Published on 2021-11-152022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome antiviral drugs Central nervous system Characteristics CNS coronavirus COVID-19 drug delivery functionalized nanoparticles herpes simplex in vitro in vivo increasingly Infection insight macromolecule nanoparticle neurotropic neurotropic viruses neurovirulent neutralizing antibody Prevent prevention probes Rabies virus reported SARS-CoV-2 sensitivity Symptoms targeted therapy therapy virus virus viruses Zika virus ZIKV [DOI] 10.3389/fmicb.2021.767104 PMC 바로가기 [Article Type] Microbiology