Genetic barrier to resistance: a critical parameter for efficacy of neutralizing monoclonal antibodies against SARS-CoV-2 in a nonhuman primate modelVaccines and Antiviral Agents Published on 2024-07-202024-09-05 Journal: Journal of virology [Category] update2024, [키워드] Antibody therapy barrier to resistance neutralizing monoclonal antibodies Nonhuman primate model SARS-CoV-2 [DOI] 10.1128/jvi.00628-24 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents
From Detection to Protection: Antibodies and Their Crucial Role in Diagnosing and Combatting SARS-CoV-2Review Published on 2024-04-252024-09-05 Journal: Vaccines [Category] update2024, [키워드] Antibody-dependent enhancement convalescent plasma COVID-19 diagnostic Immunotherapy Long COVID neutralizing monoclonal antibodies Omicron subvariants original antigenic sin SARS-CoV-2 SARS-CoV-2-specific antibodies serological assays Vaccine variants of concern (VOC) [DOI] 10.3390/vaccines12050459 PMC 바로가기 [Article Type] Review
Nasopharyngeal Viral Load Is the Major Driver of Incident Antibody Immune Response to SARS-CoV-2 InfectionMajor Article Published on 2023-12-022024-09-05 Journal: Open Forum Infectious Diseases [Category] update2024, [키워드] antibody immune responses causal mediation analysis COVID-19 neutralizing monoclonal antibodies SARS-CoV-2 [DOI] 10.1093/ofid/ofad598 PMC 바로가기 [Article Type] Major Article
Characterization of Neutralizing Monoclonal Antibodies and Identification of a Novel Conserved C-Terminal Linear Epitope on the Hemagglutinin Protein of the H9N2 Avian Influenza VirusArticle Published on 2022-11-152023-06-22 Journal: Viruses [Category] 조류인플루엔자, [키워드] H9N2 avian influenza virus HA2 Hemagglutinin protein linear B cell epitope neutralizing monoclonal antibodies [DOI] 10.3390/v14112530 PMC 바로가기
Resistance mutations in SARS-CoV-2 omicron variant after tixagevimab-cilgavimab treatmentArticle Published on 2022-11-012022-11-15 Journal: The Journal of Infection [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Abstract cilgavimab monoclonal mutations neutralizing monoclonal antibodies Omicron variant Resistance mutation SARS-CoV-2 Sequencing Tixagevimab Treatment [DOI] 10.1016/j.jinf.2022.07.014 PMC 바로가기
Neutralizing monoclonal antibodies in haematological patients paucisymptomatic for COVID-19: The GIMEMA EMATO-0321 studyMulticenter Study Published on 2022-10-012023-07-10 Journal: British Journal of Haematology [Category] COVID19(2023년), [키워드] COVID-19 haematological malignancies neutralizing monoclonal antibodies paucisymptomatic patients. [DOI] 10.1111/bjh.18385 PMC 바로가기 [Article Type] Multicenter Study
Acquisition of Furin Cleavage Site and Further SARS-CoV-2 Evolution Change the Mechanisms of Viral Entry, Infection Spread, and Cell Signaling푸린 절단 부위의 획득 및 추가 SARS-CoV-2 진화는 바이러스 진입, 감염 확산 및 세포 신호 전달의 메커니즘을 변경합니다Article Published on 2022-08-102022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 acquisition activate activating Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response alphavirus appear cathepsin Cathepsins Cell Cell fusion change coronavirus COVID COVID-19 disease Cytokines Deletion determined by endosome Entry mechanism entry pathway Evolution experimental system expressing S protein expression FCS furin furin cleavage furin cleavage site hallmark human population immune in vitro induce infected with SARS-CoV-2 infecting Infection inhibitor inhibitors lack leads Lineage mAbs mechanism media mRNA vaccines Neutralizing neutralizing monoclonal antibodies neutralizing monoclonal antibody pro-inflammatory cytokines pro-inflammatory response pseudoinfectious viruses pseudovirus pseudoviruses receptor released respiratory S protein S1 secretion S1 subunit SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 S protein secrete sera severe acute respiratory syndrome Coronavirus shown Site Spike protein Spread spreading Syncytia syncytium syncytium formation the S protein the S1 subunit TLR4 TMPRSS2 TMPRSS2 expression variant Viral viral evolution virus virus entry virus spread [DOI] 10.1128/jvi.00753-22 PMC 바로가기 [Article Type] Article
Targeting the Receptor-Binding Motif of SARS-CoV-2 with D-Peptides Mimicking the ACE2 Binding Helix: Lessons for Inhibiting Omicron and Future Variants of ConcernACE2 결합 나선을 모방한 D-펩타이드로 SARS-CoV-2의 수용체 결합 모티프 표적화: 오미크론 및 우려되는 미래 변이를 억제하기 위한 교훈Article Published on 2022-08-082022-09-11 Journal: Journal of Chemical Information and Modeling [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding Alpha approach B.1.1.529 Beta binding blocked concern COVID-19 pandemic demonstrated domain Future high-affinity binding IC50 IC50s in vitro In vitro infection Infection inhibiting inhibitor lesson motif Mutation neutralizing monoclonal antibodies omicron Omicron variant overlapping predicted public interest RBD receptor-binding motif SARS-CoV-2 Spike protein Spread targeting the RBD the spike protein variant VoC VOCs [DOI] 10.1021/acs.jcim.2c00500 PMC 바로가기 [Article Type] Article
Real-world effectiveness of casirivimab plus indevimab in a dedicated ambulatory unit created for patients with early COVID-19 during a massive delta variant wave대규모 델타 변이 파동 동안 초기 COVID-19 환자를 위해 만들어진 전용 보행 유닛에서 카시리비맙과 인데비맙의 실제 효과Article Published on 2022-08-012022-09-11 Journal: European Journal of Clinical Microbiology & Infect [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] age ambulatory Ambulatory care benefit Casirivimab Comorbidity COVID COVID-19 Delta delta variant duration of symptom early administration Effect Effectiveness high-risk patient High-risk patients Hospitalization life monoclonal antibodies mortality rate mortality rates Neutralizing antibodies neutralizing antibody neutralizing monoclonal antibodies neutralizing monoclonal antibody oxygen Oxygen requirement Patient prospectively studied Real life. supplemental oxygen variant [DOI] 10.1007/s10096-022-04474-9 PMC 바로가기 [Article Type] Article
Characterization of SARS-CoV-2 Escape Mutants to a Pair of Neutralizing Antibodies Targeting the RBD and the NTDRBD 및 NTD를 표적으로 하는 한 쌍의 중화 항체에 대한 SARS-CoV-2 탈출 돌연변이의 특성화Article Published on 2022-07-252022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] active immunization Affect antibodies antibody binding Cell culture characterization Clinical use Cluster Combination Efficacy escape escape mutant escape mutants escape mutation gene segments Genetic human immunoglobulin identify immunization immunization strategies Immunoglobulin indicate lead mice monoclonal monoclonal antibodies monoclonal antibody more difficult Mutation mutations neutralization Neutralization assay Neutralizing Neutralizing antibodies neutralizing antibody neutralizing monoclonal antibodies neutralizing monoclonal antibody nine not affected NTD pair passage pseudotype RBD RBD mutations reduced SARS-CoV-2 SARS-CoV-2 escape mutations SARS-CoV-2 variant SARS-CoV-2 variants selected Spike protein targeting the RBD the spike protein variable region variant variants variants of concern VoC [DOI] 10.3390/ijms23158177 PMC 바로가기 [Article Type] Article