Intrinsic host susceptibility among multiple species to intranasal SARS-CoV-2 identifies diverse virological, biodistribution and pathological outcomesArticle Published on 2022-11-042022-11-15 Journal: Scientific Reports [Category] SARS, 진단, [키워드] administration airway analysed association Asymptomatic atraumatic biodistribution cardiovascular systems Cell consequence cynomolgus macaque cynomolgus macaques Disrupted exhibit exhibited hamster Host host susceptibility hosts identify Infection Infectious virus intranasal Lower respiratory tract lung Lung pathology methodology Microscopy Mild molecular morphology New World NHP non-human primate organelle outcome outcomes Pathogenesis pathological outcome pathology pathophysiological Post-infection Replication representing SARS-CoV-2 SARS-COV-2 infection susceptible ultrastructure Virological virus virus particle [DOI] 10.1038/s41598-022-23339-x PMC 바로가기
Molecular diversity and phenotypic pleiotropy of ancient genomic regulatory loci derived from human endogenous retrovirus type H (HERVH) promoter LTR7 and HERVK promoter LTR5_Hs and their contemporary impacts on pathophysiology of Modern HumansArticle Published on 2022-11-012022-11-15 Journal: Molecular genetics and genomics : MGG [Category] SARS, 유전자 메커니즘, 진단, [키워드] affected Analysis Ape apes azoospermia Brain brain regions Cancer Cell cell type cells Central nervous system cognitive Consensus conserved coronavirus COVID-19 COVID-19 pandemic database defined disorders DNA sequence dominant element embryogenesis event Evidence Evolution expressed expression fetal functional gene signature Genes genes encoding Genome genomic germline global pandemic Glutamatergic GSEA HERV HERVs Human human cell Human embryogenesis human endogenous retrovirus Human endogenous retrovirus type H (HERVH) Human endogenous retrovirus type K (HERVK) human physiology Human spermatogenesis identification Impact implicated include Infection inheritance insertion Interaction Lineage loci LTR LTR5_Hs LTR7 subfamilies majority mammalian Mammalian offspring survival genes marker Metastasis Monkey morphological feature morphologically MOS naïve neoplasm Neoplasm metastasis Neural Neuron neurons New World non-human primates observation offspring Oligospermia pathogen pathology pathophysiology Phenotypes phenotypic physiological Pleiotropy Population population-level effect primate Primate evolution promoter protein-protein interaction Protein–protein interactions at synapses proteomics Quantitative Radial rare disease recessive regulated Regulatory regulatory element regulatory sequence Release replicate representing Retrotransposition retroviral retrovirus SARS-CoV-2 SARS-CoV-2 coronavirus Schizophrenia sequence significantly Spread Stage survival synaptic Synaptic transmission Synaptic transmission. target the SARS-CoV-2 timeline traits Transmission trigeminal undergo viral genome viral infection viral infections virus viruses [DOI] 10.1007/s00438-022-01954-7 PMC 바로가기
Natural SARS-CoV-2 Infection in a Free-Ranging Black-Tailed Marmoset (Mico melanurus) from an Urban Area in Mid-West Brazil브라질 중서부 도시 지역의 자유 범위 검은꼬리 마모셋(Mico melanurus)에서 자연적인 SARS-CoV-2 감염Article Published on 2022-06-012022-09-11 Journal: Journal of comparative pathology [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] alveolar septa animal Antigen Area Black-Tailed Marmoset Brazil clinical history COVID-19 female Hepatitis Host human populations immunohistochemistry Interstitial nephritis intestine large intestine liver lung lung tissue Lymph node Lymphocytes lymphoid marmoset Mild motor vehicle nasopharyngeal natural natural infection necropsy New World New World monkey nodule one health oropharyngeal swab pathogen Pathogens peribronchial periportal platyrrhines. Polytrauma pool Protein risk SARS-CoV-2 SARS-COV-2 infection Spike protein spleen state the viral nucleocapsid urban urban area viral nucleocapsid protein Viral RNA viral RNA detection [DOI] 10.1016/j.jcpa.2022.03.005 PMC 바로가기 [Article Type] Article
COVID-19 Vaccine Education (CoVE) for Health and Care Workers to Facilitate Global Promotion of the COVID-19 VaccinesArticle Published on 2022-01-072022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] aligned Care country COVID-19 COVID-19 vaccination COVID-19 vaccine Digital education element Engagement facilitated Final Health Health Education health protection healthcare implementation knowledge mechanism methodology Model New World producing professional promotion provide released resource Satisfaction Social care step Support synchronous the vaccine Vaccine was used worker [DOI] 10.3390/ijerph19020653 PMC 바로가기 [Article Type] Article
Sense of Coherence in Managers during COVID-19 and the New World of Work: A Mixed-Method StudyArticle Published on 2021-10-312022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, SARS, [키워드] age analysed Analysis approach average change changed Coherence collected complex connection COVID-19 creating determine distribution extreme female helping highest individual Interaction investigated knowledge lowest male managers medium mixed-method study New World organization Perspective Positive psychology qualitative data Quantitative recommendation Research resource salutogenesis scored sense sense of coherence South Africa Stress Structure thought [DOI] 10.3390/ijerph182111492 PMC 바로가기 [Article Type] Article
Identifying Primate ACE2 Variants That Confer Resistance to SARS-CoV-2SARS-CoV-2에 대한 내성을 부여하는 영장류 ACE2 변이체 식별Article Published on 2021-06-252022-09-25 Journal: Molecular Biology and Evolution [Category] SARS, 변종, [키워드] ACE2 ACE2 gene sequence ACE2 residue ACE2 variant Analysis angiotensin angiotensin I apes binding binding affinity collected Complete complex COVID-19 enzyme evaluate the effect Human Human angiotensin I humans identifying increase infect New World New World monkey nine Old World monkey Philippine tarsier primate primates Protein protein structure reducing reduction in resistance resistant to SARS-CoV-2. S-protein SARS-CoV-2 SARS-COV-2 infection sequence Spike protein susceptibility susceptible the binding affinity variant variants [DOI] 10.1093/molbev/msab060 PMC 바로가기 [Article Type] Article
Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathwaysResearch Article Published on 2021-06-072022-10-29 Journal: PLoS Pathogens [Category] COVID-19, [키워드] Acidic Alpha Anti-viral anti-viral activity approach arenavirus arenaviruses binding CD47 Cell cell surface receptors complexes dead cell Degradation demonstrated Ebola Ebola virus Endocytic pathway expressed greater HSV-1 human pathogen IL-4 In vitro infection Infection inhibit inhibited inhibitor Macrophage mice MLV Mutation New World pathogenic viruses pathway phagocytosis Protein pseudovirus required RNA virus SARS-CoV-2 SARS-CoV-2 pseudovirus SIRPA susceptible target cells Therapies Treatment vaccine strain variety vesicular stomatitis virus virus Zika Zika virus [DOI] 10.1371/journal.ppat.1009662 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 infection, neuropathogenesis and transmission among deer mice: Implications for spillback to New World rodents사슴 쥐 사이의 SARS-CoV-2 감염, 신경병증 및 전파: 신세계 설치류로의 유출에 대한 의미Research Article Published on 2021-05-192022-09-10 Journal: PLoS Pathogens [Category] 진단, 치료기술, [키워드] Amino acid amino acids animal model Asia bat BEI Resource BEI Resources blood-brain barrier Brain CD4 China coronavirus coronavirus disease Coronavirus disease-19 COVID-19 COVID-19 disease COVID-19 patients CXCL10 detectable disease elevated event Evidence expression fixation horseshoe bats Host humans IFNα IFNβ IFNγ IL-21 immune response in vivo Infection infiltration infiltration of neutrophil infiltration of neutrophils Inflammation inflammatory immune response innate immune response insert insertion intermediate host intestines Localization lung Lungs macrophages mice Mutation N-terminal domain neurological manifestation neurological manifestations Neuropathogenesis Neutrophils New World North America OAS2 occur occurred olfactory olfactory bulb oral swab oral swabs other coronaviruses pandemic passages pathology pathway Peromyscus maniculatus persistence Population predicted preponderance Pycard reservoir hosts respiratory Respiratory disease respiratory tract robust rodent SARS-CoV-2 SARS-COV-2 infection Spike protein susceptible sustained Taste TBK1 TBX21 the spike protein tongue Transmission type I upper respiratory tract Viral Viral RNA virus virus entry virus replication [DOI] 10.1371/journal.ppat.1009585 PMC 바로가기 [Article Type] Research Article
Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry비교 분석을 통해 SARS-CoV-2 진입에 필요한 ACE2의 종별 유전적 결정인자가 밝혀졌습니다.Research Article Published on 2021-03-242022-08-13 Journal: PLoS Pathogens [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 ortholog ACE2 orthologs ACE2 protein ACE2 proteins ACE2 sequence animal model binding can not cell entry cellular receptor Comparative analysis coronavirus Critical facilitate functional Genetic genetic determinant genetic determinants genetic engineering host cell host range Human human ACE2 Interaction koala limit mammalian mouse New World New World monkey receptor receptor function replaced REPLACED BY required residue restored restrict reveal SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 spike protein sequences shown Spike protein Support the spike protein Thr tissue tropism Viral viral entry viral spike protein [DOI] 10.1371/journal.ppat.1009392 PMC 바로가기 [Article Type] Research Article
Social Media and the New World of Scientific Communication During the COVID-19 PandemicCOVID-19 팬데믹 기간 동안 소셜 미디어와 과학 커뮤니케이션의 새로운 세계Article Published on 2020-11-192022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 유전자 메커니즘, [키워드] Analysis communication coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 epidemic COVID-19 outbreak early phase effective epidemiological lens media New World not seen pandemic primer public health responsible scientific communication social media Twitter [DOI] 10.1093/cid/ciaa553 PMC 바로가기 [Article Type] Article