High levels of soluble RAGE are associated with a greater risk of mortality in COVID-19 patients treated with dexamethasoneArticle Published on 2022-11-052022-11-15 Journal: Respiratory Research [Category] SARS, 바이오마커, [키워드] Admission association Biomarker Biomarkers Blood level Clinical management Control correlated covariates COVID-19 COVID-19 patient COVID-19 patients death Determination Dexamethasone died disease severity elevated Follow-up greater host inflammatory response IL-6 increased risk independent Infection Inflammation investigated Mortality NEWS2 Patient patient population patients patients treated Pearson positive positive individual predict prognostic RAGE receptor reduce risk SARS-CoV-2 score second wave significantly lower sRAGE. subject Teaching treated Treatment university [DOI] 10.1186/s12931-022-02220-5 PMC 바로가기
Tocilizumab, netakimab, and baricitinib in patients with mild-to-moderate COVID-19: An observational study경증에서 중등도의 COVID-19 환자에 대한 Tocilizumab, netakimab 및 baricitinib: 관찰 연구Observational Study Published on 2022-08-242022-09-12 Journal: PLoS ONE [Category] SARS, 임상, 진단, [키워드] adults hospitalized anti-IL-6R antibody Anticoagulant Antiviral average Baricitinib benefit blockers Blood C-reactive protein (CRP Clinical outcome Combination comparable COVID-19 CRP level Dexamethasone discharged dose Efficiency group groups hospital hospitalized patient Hydroxychloroquine IL-17A immunosuppressive inflamed tissues Inflammation Inflammatory marker JAK1/JAK2 inhibitor lactate dehydrogenase LDH marker Mild-to-moderate mild-to-moderate disease Mortality neutrophil neutrophil count Neutrophil-to-lymphocyte ratio NEWS2 observation Observational cohort study Patient previous study remained safety profile SARS-CoV-2 severe COVID-19 significant decrease significant increase significantly significantly increased Standard-of-care therapeutic therapy Tocilizumab treated [DOI] 10.1371/journal.pone.0273340 PMC 바로가기 [Article Type] Observational Study
Novel biomarker-based score (SAD-60) for predicting mortality in patients with COVID-19 pneumonia: a multicenter retrospective cohort of 1013 patientsCOVID-19 폐렴 환자의 사망률 예측을 위한 새로운 바이오마커 기반 점수(SAD-60): 1013명의 환자로 구성된 다기관 후향적 코호트Multicenter Study Published on 2022-06-012022-09-11 Journal: Biomarkers in Medicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] acronym age albumin COVID-19 COVID-19 pneumonia CURB CURB-65 D-dimer death highest hospitalized patient hospitalized patients In-hospital death independent predictors male Mortality multicenter Multivariate analysis NEWS2 novel occurred oxygen oxygen saturation Patient patients patients with COVID-19 peripheral capillary Peripheral capillary oxygen saturation Pneumonia predict Predictive qSOFA representing retrospective retrospective cohort risk SAD-60 score SpO2 with COVID-19 [DOI] 10.2217/bmm-2021-1085 PMC 바로가기 [Article Type] Multicenter Study
Effect of ArtemiC in patients with COVID-19: A Phase II prospective studyClinical Trial Published on 2022-06-012022-10-04 Journal: Journal of Cellular and Molecular Medicine [Category] COVID19(2023년), SARS, 임상, [키워드] adverse event Anti-inflammatory anti-SARS-CoV-2 ArtemiC Artemisinin blood test COVID-19 COVID-19 patient COVID-19 patients curcumin. Cytokine storm Day Decline Deterioration double-blinded Effect effective Efficacy and safety evaluated Fever hospital discharge Hospitalized Intensive lineages new SARS-CoV-2 NEWS2 oxygen supplementation Patient patients with COVID-19 PCR pharmacological phase Physical examination Placebo placebo-controlled Prospective Study Randomized receive reported SARS-CoV-2 standard care symptomatic those with comorbidities unmet need vaccination efficacy vital sign Vitamin Vitamin C was performed [DOI] 10.1111/jcmm.17337 PMC 바로가기 [Article Type] Clinical Trial
Baseline Plasma Gas6 Protein Elevation Predicts Adverse Outcomes in Hospitalized COVID-19 PatientsObservational Study Published on 2022-04-292022-10-05 Journal: Disease Markers [Category] COVID19(2023년), SARS, 임상, [키워드] Adverse adverse outcome Analysis baseline Biomarker clinical condition Concentration Course COVID-19 COVID-19 severity death discharge disease dysregulation Elevation ELISA enrolled evaluate Evolution fibrosis GAS6 Hospital admission Hospitalization Hypothesis ICU admission Immune homeostasis involved Italy Laboratory likelihood ratio modulating NEWS2 Odds ratio outcome pandemic parameter Patient plasma Plasma level positive predicted predictor Prognosis prognostic prospective observational study Regulation risk ROC Curve SARS-CoV-2 positive patient sensitivity severe disease specificity Stratification Support TAM thrombosis tyrosine kinase receptor variable were measured worsening [DOI] 10.1155/2022/1568352 PMC 바로가기 [Article Type] Observational Study
Clinical update on COVID-19 for the emergency clinician: Presentation and evaluation응급의사를 위한 COVID-19 임상 업데이트: 발표 및 평가Review Published on 2022-04-012022-09-11 Journal: The American journal of emergency medicine [Category] COVID19(2023년), SARS, 변종, [키워드] 2019 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 assist B.1.1.529 B.1.617.2 cardiovascular caused changes in Chest radiography clinical Clinicians Comorbidities Complication Computed tomography coronavirus coronavirus disease Coronavirus-2019 COVID COVID-19 Critically ill Delta delta variant disease emergency department end-organ Extrapulmonary Fever Gastrointestinal higher infectivity imaging include index infections Injury Lineage mild symptoms morbidity and mortality neurologic NEWS2 Older omicron Omicron variant outcomes pandemic Patient presentation presenting symptoms progressed proportion provide respiratory respiratory symptoms risk score SARS-CoV-2 several variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant increase those with comorbidities Ultrasound upper upper respiratory symptoms variant while [DOI] 10.1016/j.ajem.2022.01.028 PMC 바로가기 [Article Type] Review
A machine learning model for predicting deterioration of COVID-19 inpatientsArticle Published on 2022-02-162022-10-04 Journal: Scientific Reports [Category] MERS, 치료기술, [키워드] adjusted Clinical deterioration clinical feature COVID-19 COVID-19 pandemic defined demographics deteriorate Deterioration disease Disease progression Electronic health record external validation Health hospital hospitalized patient Infectious diseases Inpatient lab machine learning measure mechanical ventilation NEWS2 Patient predict Predictive Predictive markers presenting Prevent Prognosis Retrospective analysis risk risk factor ROC Curve suggested the disease vital signs worsening [DOI] 10.1038/s41598-022-05822-7 PMC 바로가기 [Article Type] Article
Prognostic accuracy of triage tools for adults with suspected COVID-19 in a prehospital setting: an observational cohort studyObservational Study Published on 2022-02-082022-10-04 Journal: Emergency medicine journal : EMJ [Category] MERS, 임상, [키워드] 95% CI Accuracy adverse outcome Algorithm ambulance service clinical decision Cohort conducted COVID-19 COVID-19 infection death Emergency emergency ambulance systems emergency care systems England FIVE hospital Humber IMPROVE NEWS2 Observational cohort study organ support Patient populations predict Primary outcome respiratory Result risk Risk management score sensitivity service specificity System threshold transfer transported Triage WHO [DOI] 10.1136/emermed-2021-211934 PMC 바로가기 [Article Type] Observational Study
Development and Validation of the Acute PNeumonia Early Assessment Score for Safely Discharging Low-Risk SARS-CoV-2-Infected Patients from the Emergency DepartmentArticle Published on 2022-02-082022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95% CI 95% confidence interval acute respiratory syndrome Admission appear assessment AUROC characteristic Cohort coronavirus COVID-19 cut-off death decision curve Department development discharge Discharging Emergency FIVE hospital Hospitalization hospitals intubation Negative predictive value NEWS2 not significant observational study occurred outcome Patient patients Prediction model Probability prognostic score reduced Safe SARS-CoV-2-infected patient score sensitivity tested validation validation cohort validation cohorts [DOI] 10.3390/jcm11030881 PMC 바로가기 [Article Type] Article
Soluble urokinase plasminogen activator receptor levels are predictive of COVID-19 severity in Afro-Caribbean patientsClinical Trial Published on 2022-01-272022-10-04 Journal: Biomarkers in Medicine [Category] COVID19(2023년), Fulltext, MERS, SARS, 임상, [키워드] Abstract Activation Admission Afro-Caribbean association baseline Care Chest CT chest CT severity score Coagulation Complication complications COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity CT scan death feature hazard ratio high risk hospital Hospital admission incidence Increased indicated Inflammation intensive care Kaplan–Meier analysis National Early Warning Score NEWS2 outcome Patient plasma Predictive receptor score severity soluble urokinase plasminogen activator receptor suPAR [DOI] 10.2217/bmm-2021-0669 PMC 바로가기 [Article Type] Clinical Trial