A Functional Interaction Between Y674-R685 Region of the SARS-CoV-2 Spike Protein and the Human α7 Nicotinic ReceptorArticle Published on 2022-10-012023-07-10 Journal: Molecular neurobiology [Category] COVID19(2023년), [키워드] Neurotransmitter receptors Nicotinic receptor Patch-clamp SARS-CoV-2 spike protein Single-channel recordings. [DOI] 10.1007/s12035-022-02947-8 PMC 바로가기
Nicotine patches in patients on mechanical ventilation for severe COVID-19: a randomized, double-blind, placebo-controlled, multicentre trialRandomized Controlled Trial Published on 2022-07-012022-10-04 Journal: Intensive care medicine [Category] COVID19(2023년), SARS, 임상, [키워드] active smoker Acute respiratory failure Administered Adverse affected artificial assessment assigned Care conducted confidence interval coronavirus disease COVID-19 Critically ill patient daily dose days alive dose double-blind Efficacy and safety event France function intensive care unit intensive care units Invasive mechanical ventilation IQR mechanical ventilation median men Mortality multicentre Nicotine Nicotinic receptor not differ Odds ratio on mechanical ventilation Organ failure Patient Placebo placebo-controlled placebo-controlled trial Pneumonia Primary outcome Randomized randomized trial Randomly receive receiving reduce renal replacement therapy secondary outcome Severe COVID-19 pneumonia significantly smoker stratified symptomatic patient the median the placebo group Trial two group two groups vasopressor support Ventilation ventilator-free day with COVID-19 [DOI] 10.1007/s00134-022-06721-1 PMC 바로가기 [Article Type] Randomized Controlled Trial
The role of nicotinic receptors in SARS-CoV-2 receptor ACE2 expression in intestinal epitheliaShort Report Published on 2020-10-282022-10-28 Journal: Bioelectronic Medicine [Category] COVID-19, [키워드] ACE2 ACE2 expression ACE2 receptor activate acute respiratory syndrome affecting co-expressed co-expression Colitis coronavirus COVID-19 dataset demonstrated enterocytes epithelial epithelial cell Evidence expressed expressing expression goblet cells human ACE2 Inflammation intestinal intestinal epithelia intestinal epithelial cell intestinal epithelial cells Intestinal stem cells intestinal tissue intestine investigated modulation murine nAChR nerve stimulation Nicotinic receptor not affect priming recent receptor Regulation Result risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor therapeutic these cell TMPRSS2 Vagus nerve stimulation viral infection [DOI] 10.1186/s42234-020-00057-1 PMC 바로가기 [Article Type] Short Report