Classification, replication, and transcription of NidoviralesMicrobiology Review Published on 2024-01-242024-09-05 Journal: Frontiers in Microbiology [Category] update2024, [키워드] dis-continuous RNA synthesis Host factor Nidovirales replicase replication-transcription complex transcription regulatory sequence [DOI] 10.3389/fmicb.2023.1291761 PMC 바로가기 [Article Type] Microbiology Review
SARS-CoV-2: phenotype, genotype, and characterization of different variantsSARS-CoV-2: 다양한 변이체의 표현형, 유전자형 및 특성화Article Published on 2022-06-172022-09-11 Journal: Cellular & Molecular Biology Letters [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus Alpha Amino acid amino acid sequence angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antibiotics antiviral drugs B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 B.1.621 Beta can not Clusters coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Delta domain eliminated envelope epidemiological data exceptional family Coronaviridae Gamma Genetic variation Genome Genotype Glucocorticoids Health Organization help host cells IFN-α2b Immunoglobulin include infect Infection international public health Intravenous immunoglobulin Lambda membrane Nidovirales nucleocapsid omicron P.1 patients phenotype plasma plasma therapy positive Prevent Protein receptor risk of infection RNA RNA virus SARS-CoV-2 SARS-CoV-2 variants Seven severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spread structural protein structural proteins subtype the Coronaviridae therapy Transmission treat vaccination Vaccine variant Variation variations VoC WHO World Health Organization [DOI] 10.1186/s11658-022-00352-6 PMC 바로가기 [Article Type] Article
Genomic evolution of the Coronaviridae familyArticle Published on 2022-03-302023-06-15 Journal: Virology [Category] COVID19(2023년), MERS, SARS, [키워드] Coronaviridae Evolution Genome Hidden Markov models Nidovirales Orthocoronavirinae phylogenetics Phylogenomics protein domains [DOI] 10.1016/j.virol.2022.03.005 PMC 바로가기 [Article Type] Article
Jumper enables discontinuous transcript assembly in coronaviruses점퍼는 코로나바이러스에서 불연속 전사 조립을 가능하게 합니다.Article Published on 2021-11-182022-09-10 Journal: Nature Communications [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] alignment analyses Analysis assembly canonical classical conditions coronavirus develop discontinuous transcription drug response eukaryote eukaryotes expressed expression Gene Expression Genome informatics identify JUMPER likelihood MERS-CoV Nidovirale Nidovirales outperform predict produced reveal RNA polymerase RNA splicing RNA-dependent RNA polymerase SARS-CoV-1 SARS-CoV-2 Software subsequent supported transcript transcriptional change Transcriptional changes Transcriptome transcriptomes transcripts Treatment Viral Viral RNA viral RNA-dependent RNA polymerase virus viruses [DOI] 10.1038/s41467-021-26944-y PMC 바로가기 [Article Type] Article
Insights into COVID-19 Vaccine Development Based on Immunogenic Structural Proteins of SARS-CoV-2, Host Immune Responses, and Herd ImmunityReview Published on 2021-10-292022-10-31 Journal: Cells [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress acute respiratory syndrome addition aetiology affected alveolar epithelial cells antigenicity approval ARDS authority caused Cell-mediated immune responses characterized China clinical trial clinical trials coronavirus disease coronavirus disease 19 Coronaviruses COVID-19 COVID-19 vaccine death deaths develop development Disadvantages disease Effective vaccines Efficiency EMA epidemiologist European family Coronaviridae genus Betacoronavirus glycoprotein H1N1 Herd herd immunity humoral immune response Immunity immunocompromised individuals immunogenic immunogenic potential Infection Infectious disease Influenza insight janssen Lungs majority Medicine MERS Middle East morbidity and mortality Nidovirales non-structural proteins organ Orthocoronavirinae other tissue outbreak pandemic Prognosis prophylactic measure PROTECT psychosomatic reduce reported researchers Safe SARS-CoV SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 pandemic severe patients structural protein syndrome therapeutic agents vaccination Vaccine Vaccine development Vaccines Viral diseases VoC Wuhan [DOI] 10.3390/cells10112949 PMC 바로가기 [Article Type] Review
The taxonomy, host range and pathogenicity of coronaviruses and other viruses in the Nidovirales orderReview Published on 2021-04-232022-10-28 Journal: Animal Diseases [Category] COVID-19, [키워드] Analysis benefit caused coronavirus CoV COVID-19 pandemic CoVs cross Diseases Epidemic Epidemics Evolution feature Genetic variation genetics genomic highly pathogenic Host host range hosts infect information mammals Nidovirale Nidovirales nidovirus nidoviruses pathogenic pathogenicity Phylogenetic relationship promote public health Research S protein the Coronaviridae Transmission variety Viral detection viral disease viral genome Virological virus viruses [DOI] 10.1186/s44149-021-00005-9 PMC 바로가기 [Article Type] Review
SARS-CoV-2 hot-spot mutations are significantly enriched within inverted repeats and CpG island lociSARS-CoV-2 핫스팟 돌연변이는 역 반복 및 CpG 섬 유전자좌 내에서 상당히 풍부합니다Case Study Published on 2021-03-212022-09-10 Journal: Briefings in Bioinformatics [Category] SARS, 변종, [키워드] Analysis bioinformatics carried cause Coronaviridae family COVID-19 disease CpG CpG methylation creating decrease effort genomic hot spot humans inverted repeats investigated life cycle limit loci Mutation Nidovirale Nidovirales ORF predict progression SARS-CoV-2 SARS-CoV-2 genome sequenced significantly the disease the SARS-CoV-2 genome Transcription upstream Viral viral life cycle viral strain viral strains virus [DOI] 10.1093/bib/bbaa385 PMC 바로가기 [Article Type] Case Study
Reverse vaccinology approach towards the in-silico multiepitope vaccine development against SARS-CoV-2SARS-CoV-2에 대한 in-silico 다중 에피토프 백신 개발을 위한 역백신학 접근법Research Article Published on 2021-01-232022-09-11 Journal: F1000Research [Category] 치료법, [키워드] acute respiratory syndrome adjuvant allergen allergenicity Antigen antigenicity approach B cell epitope B cell epitopes binding binding affinity C terminal CAI calculated caused codon adaptation index complex Corona virus coronavirus disease Coronavirus disease 2019 COVID-19 cytotoxic Cytotoxic T cell disease docked docking E. coli effective Epitopes experimental validation expression fatal COVID-19 GC content helper T cell human body immunization immunoinformatics in-silico membrane MHC molecular dynamics Molecular dynamics simulation molecular dynamics simulations multiepitope multiepitope based vaccine multiepitope vaccine Nidovirales nucleocapsid online tool pandemic pandemic coronavirus polyprotein predict predicted receptor reduction respiratory Result RMSD SARS-CoV-2 sequence Simulations spike Spread suggested T cell T cell epitopes the binding affinity tlr-3 Toxicity Vaccine vaccine candidate Vaccine development were used [DOI] 10.12688/f1000research.36371.1 PMC 바로가기 [Article Type] Research Article
Coronaviruses: An Updated Overview of Their Replication and PathogenesisArticle Published on 2020-11-172023-06-14 Journal: Methods in molecular biology (Clifton, N.J.) [Category] MERS, SARS, [키워드] coronavirus MERS-CoV Nidovirales positive-sense RNA viruses SARS-CoV [DOI] 10.1007/978-1-0716-0900-2_1 PMC 바로가기 [Article Type] Article
Phytochemicals from Selective Plants Have Promising Potential against SARS-CoV-2: Investigation and Corroboration through Molecular Docking, MD Simulations, and Quantum Computations선택적 식물의 파이토케미컬은 SARS-CoV-2에 대한 유망한 잠재력을 가지고 있습니다: 분자 도킹, MD 시뮬레이션 및 양자 계산을 통한 조사 및 확증Research Article Published on 2020-10-132022-09-10 Journal: BioMed Research International [Category] 치료제, [키워드] acute respiratory syndrome Analysis analyzed association Beta Beta coronaviruses binding binding affinity Care caused Compound compounds Coronaviridae Coronavirus-2 docked glycoside Helicase in viral in vitro in vivo Infection inhibitor investigation MERS methyltransferase Middle East Middle East respiratory syndrome molecular molecular dynamics molecular dynamics simulations Nidovirale Nidovirales nonstructural protein nonstructural proteins nsp13 pandemic Pathogenesis performed pharmacological phytochemical plant positive Potential Protein protocols quantum reactivity reported respiratory Rhamnetin Ribonucleic acid SARS-CoV-2 screened Sesquiterpene Severe acute respiratory syndrome single-stranded subject syndrome these compound these compounds these viruses treat Vaccine Viral viral pathogenesis virus viruses Wuhan Wuhan, China [DOI] 10.1155/2020/6237160 PMC 바로가기 [Article Type] Research Article