SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2DArticle Published on 2022-12-272023-07-11 Journal: Cell Reports [Category] COVID19(2023년), [키워드] antiviral immunity COVID-19 CP: Immunology CP: Microbiology Immune escape Innate immunity Natural killer cells NK cells NKG2D nsp1 SARS-CoV-2 [DOI] 10.1016/j.celrep.2022.111892 PMC 바로가기
STAT1 is associated with NK cell dysfunction by downregulating NKG2D transcription in chronic HBV-infected patientsArticle Published on 2022-11-012023-06-13 Journal: Immunobiology [Category] B형 간염, [키워드] Chronic hepatitis B infection Hepatitis B envelope antigen natural killer cell NKG2D PD-1 Stat1 TIM-3 [DOI] 10.1016/j.imbio.2022.152272
Prognostic Value of Serum MICA Levels as a Marker of Severity in COVID-19 PatientsArticle Published on 2022-08-012023-07-09 Journal: Immunological investigations [Category] COVID19(2023년), [키워드] COVID-19 Innate immunity MHC class I related chain a NKG2D sMICA. [DOI] 10.1080/08820139.2022.2069035
Effective Natural Killer Cell Degranulation Is an Essential Key in COVID-19 EvolutionObservational Study Published on 2022-06-132022-10-05 Journal: International Journal of Molecular Sciences [Category] 임상, [키워드] Analysis analyzed association Benign Cell clearance complex conducted Control COVID-19 COVID-19 patient cytotoxic activity degranulation degranulation activity early stage Essential Evolution expression form forms granzymes healthy control hospital identify Immune cell immunological profile independent risk factor Infection Innate innate immune cell Innate immunity natural natural killer natural killer. NK cell NKG2D NKT cell non-severe patient outcome Patient prospective observational study protective factor severe patients severity subjects subpopulation the disease the healthy [DOI] 10.3390/ijms23126577 PMC 바로가기 [Article Type] Observational Study
Integrated analysis of circulating immune cellular and soluble mediators reveals specific COVID19 signatures at hospital admission with utility for prediction of clinical outcomes순환 면역 세포 및 가용성 매개체의 통합 분석Research Paper Published on 2022-01-012022-09-10 Journal: Theranostics [Category] 바이오마커, [키워드] activated activating adaptive addition Analysis analyzed asymptomatic infection Blood caused CCL2 CCL8 CD8+ Cell cellular chemokine chemokines circulating clinical manifestation clinical manifestations Clinical outcome Clustering cold-like symptom cold-like symptoms complex comprehensive analysis coronavirus disease Coronavirus disease 2019 correlated COVID19 COVID19 patient COVID19 patients Critical care CXCL10 CXCL9 Cytokines deregulated disease disease course disease severity exacerbated experimental variable expressing expression Extracellular Frequency GzmA GzmB healthy donors heterogeneous Hospital admission Hospitalization Host immune response IFNα IL18 IL1RA IL2 IL31 IL36B immune immune response immune signature immunological IMPROVE Infection Inflammation Inflammatory cytokine Inflammatory cytokines Inflammatory factor LAG3 Ligand ligands MIC Mild monocyte Monocytes Multivariate analysis NK cell NK cells NKG2D organ damage Patient PD1 predict Prognosis receptor reduction respiratory respiratory tract infection Respiratory tract infections reveal risk of death SARS-CoV-2 Sepsis Severe case similarity subset TNFα ULBP utility variety [DOI] 10.7150/thno.63463 PMC 바로가기 [Article Type] Research Paper
SARS-CoV-2 peptides bind to NKG2D and increase NK cell activitySARS-CoV-2 펩타이드는 NKG2D에 결합하여 NK 세포 활성을 증가시킵니다Article Published on 2022-01-012022-09-12 Journal: Cellular immunology [Category] MERS, SARS, 진단, [키워드] Activation acute respiratory syndrome binding cells coronavirus coronavirus disease COVID-19 cytotoxicity dysregulation Genes IFN-γ in silico analysis induce innate immune cell innate immune system Interaction interferon gamma lung cancer modulation natural killer NK NK cell NK cells NKG2D Patient peptide peptides Phosphorylation receptor receptors response SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 S protein screened severe lung inflammation stimulated therapeutic target [DOI] 10.1016/j.cellimm.2021.104454 PMC 바로가기 [Article Type] Article
Severe COVID-19 patients exhibit an ILC2 NKG2D + population in their impaired ILC compartmentCorrespondence Published on 2020-12-142022-11-01 Journal: Cellular and Molecular Immunology [Category] COVID-19, Fulltext, MERS, [키워드] COVID-19 patient Infection Innate lymphoid cells NKG2D [DOI] 10.1038/s41423-020-00596-2 PMC 바로가기 [Article Type] Correspondence
Unique immunological profile in patients with COVID-19COVID-19 환자의 독특한 면역 프로필Clinical Trial Published on 2020-10-152022-08-13 Journal: Cellular and Molecular Immunology [Category] MERS, SARS, 바이오마커, 임상, 치료제, [키워드] (PD-1 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adaptive Analysis CD56 CD57 CD69 CD8 Cell contraction Coronavirus-2 COVID-19 COVID-19 patient Cytokines Deceased disease distribution driven by effective expansion expression FcεRIγ Frequency healthy subject healthy subjects help host immunity IL-1β IL-6 IL-8 IL6 immature immune response immune responses Immunoglobulin immunological profile Increased Infection Inflammatory cytokine Inflammatory cytokines interferon Interleukins lectin Lymphocytes monocyte Monocytes Monocytes and macrophages mucin natural killer NK cell NK cells NKG2D outcome overexpressed Patient patients with COVID-19 PD-1 performed Peripheral blood peripheral blood lymphocytes positive cell positive cells programmed cell death programmed cell death protein proportion Protein reduced respiratory restoration SARS-CoV-2 SARS-COV-2 infection secrete secreted secretion Serum level Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe COVID-19 severe SARS severe SARS-CoV-2 sialic acid Survivors T cell T cells T-cell TIM-3 Treatment unique viral infection with COVID-19 [DOI] 10.1038/s41423-020-00557-9 PMC 바로가기 [Article Type] Clinical Trial
Diagnostic value of NKG2D promoter methylation in hepatitis B virus-associated hepatocellular carcinomaArticle Published on 2019-09-012023-06-16 Journal: Biomarkers in Medicine [Category] B형 간염, [키워드] DNA methylation Hepatocellular carcinoma NKG2D [DOI] 10.2217/bmm-2019-0102
miR-20a regulates sensitivity of colorectal cancer cells to NK cells by targeting MICAarticle Published on 2019-04-152024-09-02 Journal: Bioscience Reports [Category] 대상포진, [키워드] CRC MICA microRNA miR-20a Natural killer cells NKG2D [DOI] 10.1042/BSR20180695 PMC 바로가기 [Article Type] article