LNCGM1082-mediated NLRC4 activation drives resistance to bacterial infectionarticle Published on 2023-05-312024-09-01 Journal: Cellular & molecular immunology [Category] 살모넬라증, [키워드] Cell pyroptosis Inflammasome lncRNA macrophages NLRC4 PKCδ [Article Type] article
Identification of ultra-rare genetic variants in pediatric acute onset neuropsychiatric syndrome (PANS) by exome and whole genome sequencing Research Published on 2022-06-302022-10-05 Journal: Scientific Reports [Category] 바이오마커, 변종, 유전자 메커니즘, [키워드] abrupt onset Anxiety biological pathways CACNA1B candidate candidate gene categories category children Cohort conducted de novo Deleterious described disorder disrupting etiology European Evidence Exome expressed functional GABRG2 Genes Genetic variant Genetic variation GRIN2A heterogeneous identification immune functions Infection infections irritability microglia Mutation nervous system neuronal Neuropsychiatric NLRC4 pathological mechanism pediatric peripheral immune response PLCG2 PPM1D RAG1 regulate selected Sequencing SGCE SHANK3 Stressor subject swings Symptom syndrome SYNGAP1 union variant WES WGS whole genome [DOI] 10.1038/s41598-022-15279-3 [Article Type] Research
SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathwayORF3a에 의해 암호화된 SARS-CoV-2 비로포린은 NLRP3 염증 경로를 유발합니다Article Published on 2022-03-012022-09-11 Journal: Virology [Category] SARS, 변종, 치료제, [키워드] activate Amino acid amino acid residue Antiviral conserved COVID-19 COVID-19 disease cytokine drug efflux epithelial cell epithelial cells expressed expression IL-1β Infection Inflammasome inflammasome activation inflammasomes Inflammatory Inflammatory response inhibitor Intervention isolate kinase maturation NEK7 NFκB NLRC4 NLRP1 NLRP3 NLRP3 inflammasome oligomerization ORF3 ORF3a pathway Potassium potassium ion priming resulting SARS-CoV-2 SARS-CoV-2 isolates severe COVID-19 disease target the SARS-CoV-2 Trigger variants of SARS-CoV-2 Viroporin. virus [DOI] 10.1016/j.virol.2022.01.003 PMC 바로가기 [Article Type] Article
Evolutionary loss of inflammasomes in the Carnivora and implications for the carriage of zoonotic infectionsArticle Published on 2021-08-242023-05-31 Journal: Cell Reports [Category] Fulltext, 조류인플루엔자, [키워드] Carnivora caspase 1 caspase 11 caspase 4 Inflammasome NLRC4 NLRP3 [DOI] 10.1016/j.celrep.2021.109614 PMC 바로가기 [Article Type] Article
Key Components of Inflammasome and Pyroptosis Pathways Are Deficient in Canines and Felines, Possibly Affecting Their Response to SARS-CoV-2 InfectionInflammasome 및 Pyroptosis 경로의 주요 구성 요소는 송곳니와 고양이에서 결핍되어 SARS-CoV-2 감염에 대한 반응에 영향을 미칠 수 있습니다Immunology Published on 2021-01-282022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 치료기술, [키워드] Activation activation of inflammasome AIM2 canine canines cats cause Comparative genomics component COVID-19 pandemic cytokine Cytokine storm deficiencies deficiency Deficient dog Excessive activation felines genomics study GSDMB GSDME Host infected with SARS-CoV-2 Infection Inflammasome mechanism Mild Mild symptom mild symptoms natural NLRC4 NLRP1 pathway performed pyroptosis reducing response SARS-CoV-2 SARS-COV-2 infection Severe Acute Respiratory Syndrome Corona Virus 2 Symptom Trigger [DOI] 10.3389/fimmu.2020.592622 PMC 바로가기 [Article Type] Immunology
Type 1 interferon-dependent repression of NLRC4 and iPLA2 licenses down-regulation of Salmonella flagellin inside macrophages타입 1 인터페론 의존성 NLRC4 및 iPLA2 억제는 대식세포 내에서 살모넬라 플라젤린의 하향 조절을 허용한다.Article Published on 2020-11-242024-08-21 Journal: Microbial Cell Factories [Category] 살모넬라증, [키워드] flagellin Inflammasome NLRC4 Salmonella type 1 interferon
WDR90 is a new component of the NLRC4 inflammasome involved in Salmonella Typhimurium resistancearticle Published on 2019-11-302024-09-01 Journal: Developmental & Comparative Immunology [Category] 살모넬라증, [키워드] Bacterial infection Inflammasome NLRC4 WDR90 zebrafish [Article Type] article
Triggers of NLRC4 and AIM2 inflammasomes induce porcine IL-1β secretionarticle Published on 2018-12-312024-09-01 Journal: Veterinary Research Communications [Category] 살모넬라증, [키워드] AIM2 Interleukin-1beta macrophages NLRC4 pig [Article Type] article
NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8NAIP-NLRC4 염증소체는 카스파제-1 및 -8의 활성화를 통해 에이코사노이드 및 IL-18 방출과 함께 장 상피 세포 배출을 조정합니다.Article Published on 2017-04-182024-08-21 Journal: Immunity [Category] 살모넬라증, [키워드] ASC caspase-1 caspase-8 expulsion extrusion Inflammasome intestinal epithelial cell. NAIP NLRC4
Salmonella Typhimurium Diarrhea Reveals Basic Principles of Enteropathogen Infection and Disease-Promoted DNA Exchange살모넬라 타이피무리움 설사는 장병원체 감염 및 질병 촉진 DNA 교환의 기본 원리를 드러낸다.Article Published on 2017-04-122024-08-21 Journal: Cell Host & Microbe [Category] 살모넬라증, [키워드] antibody epithelium Inflammasome Inflammation microbiota mucosa NLRC4 phage Plasmid secretory IgA