B-cell repopulation dynamics and drug pharmacokinetics impact SARS-CoV-2 vaccine efficacy in anti-CD20-treated multiple sclerosis patientsArticle Published on 2022-11-012022-11-15 Journal: European journal of neurology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] 95% CI 95% confidence interval Affect anti-CD20 anti-CD20 treatment antibody Antibody Response Antibody titers B cell B cells B-cell B-cell depletion Blood booster cellular response Cohort correlated detectable develop Efficacy Guidance humoral identify IgG^{+} interleukin-13 Logistic regression median memory multiple sclerosis naïve no correlation Odds ratio Patient patients predict predictor Probability recent rituximab S1 domain SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine Seroconversion T-cell Response treated Treatment turn vaccination vaccine responses [DOI] 10.1111/ene.15492 PMC 바로가기
Neutrophil Extracellular Traps, Local IL-8 Expression, and Cytotoxic T-Lymphocyte Response in the Lungs of Patients With Fatal COVID-19Article Published on 2022-11-012022-11-16 Journal: Chest [Category] COVID19(2023년), SARS, 치료기술, [키워드] Analysis analyzed association Bacteria bronchiolar CD8+ T-cell chemokine correlated COVID-19 CXCL8 Cytokines cytotoxic death Defense Diseases eight exploratory expression Extracellular fatal COVID-19 function heterogeneity IL-8 immune response immunohistochemistry infiltration Inflammation Inflammatory inherent leukocyte liver tissues Local lung Lungs mechanism Messenger RNA mRNA mRNA levels multiplexed immunofluorescence NET NETosis NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils no correlation pathogenic Patient polymerase chain pulmonary thrombi quantified Respiratory failure response SARS-CoV-2 severe COVID-19 shown T-lymphocyte the SARS-CoV-2 tissue tissue damage tissue viral load validation cohorts viral loads [DOI] 10.1016/j.chest.2022.06.007 PMC 바로가기
Evaluation of the relative potential for contact and doffing transmission of SARS-CoV-2 by a range of personal protective equipment materialsArticle Published on 2022-10-052022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome Adsorption aerosol analysed antiviral potency caused Community Contact coronavirus coronavirus disease correlation doffing Efficacy equipment evaluated global public health healthcare Infection Ion m/z negative correlation no correlation Personal protective equipment Physicochemical properties Polymer positive PPE Protective reduction in Regression model SARS-CoV-2 transmission the SARS-CoV-2 titre Transmission transmission of SARS-CoV-2 virion virus while [DOI] 10.1038/s41598-022-20952-8 PMC 바로가기
Neuropathological findings in fatal COVID-19 and their associated neurological clinical manifestationsArticle Published on 2022-10-012022-11-16 Journal: Pathology [Category] COVID19(2023년), SARS, 치료기술, [키워드] Autopsy Brain calculated case sery CD8 Cell Central nervous system clinical clinical manifestation clinical manifestations correlated correlation COVID-19 described Encephalopathy fatal COVID-19 FIVE highest hospitalisation hypoxic IL-6 illness duration intensive care lesion lesions macrophage activation syndrome microglial microthrombi Neuroinflammation neurological Neurological symptoms Neuropathology no correlation one patient onset of symptoms parameter pathology Patient patients performed Pituitary proportion qRT-PCR quantification retrospective SARS-CoV-2 RNA severe COVID-19 patient systemic inflammation T-cell activation Two patient Vascular [DOI] 10.1016/j.pathol.2022.03.006 PMC 바로가기
Analysis of SARS-CoV-2 viral loads in stool samples and nasopharyngeal swabs from COVID-19 patients in the United Arab EmiratesArticle Published on 2022-09-222022-11-15 Journal: PLoS ONE [Category] SARS, 치료기술, [키워드] Analysis Antibiotics Blood clinical factors clinical information Coronavirus disease 2019 correlation cough COVID-19 COVID-19 patient COVID-19 patients cross-sectional demographic detectable Diagnosis diarrhea disorder Factor fecal Follow-up Gender highlight Hospitalization Infection investigated Isolation laboratory-confirmed male medical record Mild nasopharyngeal sample Nasopharyngeal swab nasopharyngeal swabs no correlation onset of symptom Participants Patient Pneumonia positive positive correlation positively correlated proportion questionnaire Regression respiratory sample rhesus SARS-CoV-2 viral load Stool stools Symptom tested the disease the patient United Arab Emirate United Arab Emirates Viral load Viral RNA virus was collected [DOI] 10.1371/journal.pone.0274961 PMC 바로가기
SARS-CoV-2 specific T cell and humoral immune responses upon vaccination with BNT162b2: a 9 months longitudinal studyArticle Published on 2022-09-142022-11-15 Journal: Scientific Reports [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome BNT162b2 vaccine booster dose Cellular immune response changes in conducted coronavirus coronavirus disease COVID-19 demonstrated dose first vaccination follow-up period highest hospital humoral humoral immune response IgG IgG antibody immune response neutralization Neutralizing activity neutralizing antibody no correlation performed receiving SARS-CoV-2 SARS-CoV-2 neutralizing antibodies SARS-CoV-2 spike second vaccination serological Seven significantly sustained T cell T cell assay T cell response T cell responses the vaccine vaccination [DOI] 10.1038/s41598-022-19581-y PMC 바로가기
Follow-up evaluation of patients with liver test abnormalities detected during SARS-CoV2 infectionSARS-CoV2 감염 중 간검사 이상 소견이 발견된 환자에 대한 추적조사Observational Study Published on 2022-09-012022-09-11 Journal: Journal of viral hepatitis [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] Abnormalities abnormality Admission antibiotic Blood blood test coronavirus disease Coronavirus disease-19 COVID-19 criteria defined discharge disease during admission evaluated Evolution Factor Fatty liver fatty liver disease ferritin Follow-up Gender immunomodulatory individuals Infection inspired oxygen fraction liver Liver Biopsy Liver function Liver function test liver function tests male metabolic-associated fatty liver disease (MAFLD). Most patient Most patients no correlation Non-invasive observational study outcome oxygen P/F partial pressure Partial pressure of oxygen Patient patients persistent Retrospective analysis SARS-CoV2 SARS-CoV2 infection severity Treatment variable was performed [DOI] 10.1111/jvh.13718 PMC 바로가기 [Article Type] Observational Study
Impacts of the COVID-19 pandemic on pharmaceuticals in wastewater treated for beneficial reuse: Two case studies in central PennsylvaniaArticle Published on 2022-09-012022-11-16 Journal: Journal of environmental quality [Category] 치료기술, [키워드] acute respiratory syndrome affected analyzed Antibiotics Area authority calculated collected Concentration concentrations connection coronavirus COVID-19 pandemic Dexamethasone doxycycline effective explained facility FIVE Health highlight hospitalized patient Hydroxychloroquine Impact Medicine no correlation occurred pandemic patients with COVID-19 persistence plant plants powerful tool Quotient Reclamation Remdesivir returned reuse risk Sample state Surveillance therapeutic agent treated Treatment university utility Variation virus water with COVID-19 would increase [DOI] 10.1002/jeq2.20398 PMC 바로가기
SARS-CoV-2-reactive IFN-γ-producing CD4 + and CD8 + T cells in blood do not correlate with clinical severity in unvaccinated critically ill COVID-19 patients혈액 내 SARS-CoV-2 반응성 IFN-γ 생성 CD4 + 및 CD8 + T 세포는 백신 접종을 받지 않은 중환자 COVID-19 환자의 임상 중증도와 상관관계가 없습니다Article Published on 2022-08-222022-09-11 Journal: Scientific Reports [Category] SARS, 바이오마커, 진단, 치료기술, 치료법, [키워드] anti-RBD Anti-RBD IgG association Biomarker Biomarkers Blood blood levels C-reactive protein CD4 CD8 Clinical outcome Clinical severity comparable Concentration correlation COVID-19 patient COVID-19 patients Critically ill critically ill COVID-19 patients D-dimer Deceased detectable died different time point different time points ELISA Enumeration enzyme enzyme-linked immunosorbent assay examined ferritin flow cytometry greater magnitude IFN-γ IgG level increased mortality interleukin interleukin-6 investigated Kinetics Lactose Lower respiratory tract male median age membrane protein Mortality no correlation Patient patients Peripheral blood predict respiratory RNA loads SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 S sera Serum level serum levels specimens spike Spike protein survived Survivors T cell T cell subset T cells T-cell T-cell Response T-cell responses tracheal aspirate Viral viral clearance [DOI] 10.1038/s41598-022-18659-x PMC 바로가기 [Article Type] Article
Six-Month Follow-Up of Immune Responses after a Rapid Mass Vaccination against SARS-CoV-2 with BNT162b2 in the District of Schwaz/AustriaSchwaz/Austria 지역에서 BNT162b2를 사용한 SARS-CoV-2에 대한 신속한 대량 백신 접종 후 면역 반응의 6개월 추적Article Published on 2022-07-272022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] age Analysis antibody Antibody Response B-cell response B.1.351 Beta BNT162b2 carried correlated COVID-19 detect District enrolment evaluate immune response immune responses Infection mass mass vaccination natural infection new SARS-CoV-2 no correlation outbreak participant participated preserved provide Rapid reduction in response robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections second dose Seropositivity Serum level serum levels specific antibodies spring study participant subject Support T cell T cell response T cell responses T-cell Response the District the SARS-CoV-2 vaccination variant waned was measured [DOI] 10.3390/v14081642 PMC 바로가기 [Article Type] Article