Remdesivir does not affect mitochondrial DNA copy number or deletion mutation frequency in aged male rats: A short reportArticle Published on 2022-10-262022-11-16 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] Affect age Brain clinical samples coronavirus determine digital PCR DNA Effect Frequency Future hearts Hypothesis individuals inhibiting kidneys liver majority male mammals mitochondrial Mutation no effect not affect Older patients with moderate Remdesivir RNA-directed RNA polymerases rodents SARS-CoV-2 Skeletal muscle Support therapy tissue treated Treatment Viral RNA [DOI] 10.1371/journal.pone.0271850 PMC 바로가기
Antiviral efficacy of favipiravir against Zika and SARS-CoV-2 viruses in non-human primates Research Published on 2022-08-302022-10-05 Journal: Nature Communications [Category] SARS, 임상, 치료기술, 치료법, 치료제, [키워드] animal model animal models antiviral activity Clinical efficacy clinical evaluation clinical trial COVID-19 pandemic cynomolgus macaques disease drug Efficacy euthanized evaluate evaluated Evidence Favipiravir High dose implementation in vitro in vitro result Infection initiated no effect non-human primate plasma rapid clinical deterioration RNA virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral kinetics SARS-CoV-2 virus statistically significant reduction Support tested translation treated viral kinetics Viral load worsening Zika Zika virus [DOI] 10.1038/s41467-022-32565-w [Article Type] Research
Exploring the Impact of ACE Inhibition in Immunity and Disease면역 및 질병에 대한 ACE 억제의 영향 탐색Review Published on 2022-08-042022-09-11 Journal: Journal of the Renin-Angiotensin-Aldosterone Syste [Category] SARS, 치료기술, [키워드] ACE ACE inhibitor ACE inhibitors aldosterone Alter angiotensin Angiotensin II angiotensin receptor blocker Angiotensin receptor blockers Angiotensin-converting enzyme Antibiotic resistance Antigen presentation ARBs Arthritis Autoimmune autoimmune conditions Autoimmune disease Autoimmune diseases benefit Cancer Complication contribute coronavirus Diseases elevated enzyme highlight human neutrophil human neutrophils Immune cell immune cell populations immune cells immune regulation Immunocompromise Impact implicated independent independent of Infection Inflammation inflammatory immune cell inflammatory immune cells inhibition inhibitor Lupus Macrophage macrophages malignancy neurodegenerative Neutrophils no effect outcome overactive overexpression pandemic Patient phagocytosis RAAS Renin renin-angiotensin-aldosterone system Research responses rheumatoid arthritis risk ROS SARS-CoV2 therapeutic interventions understanding wake Zinc [DOI] 10.1155/2022/9028969 PMC 바로가기 [Article Type] Review
Human milk inhibits some enveloped virus infections, including SARS-CoV-2, in an intestinal model모유는 장 모델에서 SARS-CoV-2를 포함한 일부 외피 바이러스 감염을 억제합니다Article Published on 2022-08-042022-09-11 Journal: Life Science Alliance [Category] SARS, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis antibodies antiviral activity ATP1A1 block blocked change Complete inhibition coronavirus Culture Defense demonstrated down-regulation endocytic evaluated fetal Human human milk Infant Infants Infection infections inhibit inhibition intestinal intestinal cell Middle East Middle East respiratory syndrome Coronavirus milk monolayer no effect Protective respiratory respiratory syncytial virus respiratory syndrome coronavirus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 spike-specific severe acute respiratory syndrome Coronavirus specific antibodies subsequent suggested Transcriptome transcriptome analysis transcriptomic treated Treatment virus viruses [DOI] 10.26508/lsa.202201432 PMC 바로가기 [Article Type] Article
Cardiovascular drugs and COVID-19 clinical outcomes: a systematic review and meta-analysis of randomized controlled trials심혈관계 약물 및 코로나19 임상 결과: 무작위 대조 시험의 체계적인 검토 및 메타 분석Review Published on 2022-08-012022-09-11 Journal: British Journal of Clinical Pharmacology [Category] 임상, 진단, [키워드] 95% CI 95% confidence interval Accuracy ACEi ACEIs amlodipine angiotensin angiotensin receptor blocker angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors Anticoagulants anticoagulation antiplatelet approved ARBs Aspirin atorvastatin baseline blocker calcium calcium channel calcium channel blockers cardiovascular cardiovascular drugs Clinical outcome Completeness COVID-19 COVID-19 severity database drug Evidence had no Hospitalization identify initiated investigated Living systematic review mean difference meta-analyses Meta-analysis moderate Mortality no effect not affect observational studies observational study Other outcomes Prevent Quantitative Randomized controlled trial RCT RCTs receptor receptor blocker reported risk risk ratio searched severity sulodexide systematic review therapeutic therapeutic anticoagulation treat Trial trials [DOI] 10.1111/bcp.15331 PMC 바로가기 [Article Type] Review
Highly polymerized proanthocyanidins (PAC) components from blueberry leaf and stem significantly inhibit SARS-CoV-2 infection via inhibition of ACE2 and viral 3CLpro enzymes블루베리 잎과 줄기의 PAC(고중합 프로안토시아니딘) 성분은 ACE2 및 바이러스 3CLpro 효소의 억제를 통해 SARS-CoV-2 감염을 크게 억제합니다.Article Published on 2022-07-302022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro ACE2 angiotensin Angiotensin II Angiotensin II converting Enzyme antiviral activity Antiviral effect Blueberry component COVID-19 cysteine cysteine protease develop effective enzyme examined extension fraction HCV hepatitis C hepatitis C virus highest HTLV-1 Infection inhibit SARS-CoV-2 inhibited inhibitory effect Inhibitory effects leukemia neutralization neutralization test no effect polymerization polymerized proanthocyanidin Proanthocyanidins pseudotyped SARS-CoV-2 reported SARS-CoV-2 SARS-COV-2 infection significantly Treatment Vaccinium Viral chymotrypsin-like cysteine protease (3CLpro). virus worldwide pandemic [DOI] 10.1016/j.bbrc.2022.04.072 PMC 바로가기 [Article Type] Article
Are Pain Polymorphisms Associated with the Risk and Phenotype of Post-COVID Pain in Previously Hospitalized COVID-19 Survivors?이전에 입원한 COVID-19 생존자의 통증 다형성이 COVID-19 이후 통증의 위험 및 표현형과 관련이 있습니까?Article Published on 2022-07-262022-09-11 Journal: Genes [Category] 변종, [키워드] All participants Anxiety association BDNF carried clinical feature Clinical features cognitive collected COMT COVID-19 de novo depressive distribution distributions Features female Gender Genotype Hospitalization hospitalized COVID-19 HTR1B involved kinesiophobia long-COVID Musculoskeletal neuropathic neuropathic pain no differences no effect not significantly different nucleotide OPRM1 Pain participant Participants participated phenotypic feature phenotypic features polymerase chain reaction polymerase chain reactions polymorphism Post-COVID Psychological risk rs4680 rs6265 selected sensitization single nucleotide Single nucleotide polymorphism sleep quality SNP SNPs survivor Survivors Symptom Symptoms variable variant were assessed [DOI] 10.3390/genes13081336 PMC 바로가기 [Article Type] Article
Antiviral drug treatment for nonsevere COVID-19: a systematic review and network meta-analysis중증이 아닌 COVID-19에 대한 항바이러스제 치료: 체계적인 검토 및 네트워크 메타 분석Meta-Analysis Published on 2022-07-252022-09-11 Journal: CMAJ : Canadian Medical Association journal = jour [Category] COVID19(2023년), meta-analysis, SARS, 변종, 치료제, [키워드] 95% CI 95% confidence interval Admission Adult patients antiviral drug antiviral drugs antiviral treatments approach assessment certainty certainty of evidence conducted COVID-19 database death development drug effective Effectiveness Evidence Hospital admission Hospital admissions moderate molnupiravir MOST Network meta-analysis Nirmatrelvir no effect omicron Omicron variant Patient patients patients with COVID-19 performed Placebo randomized trial randomized trials reduce reduced risk reducing Remdesivir risk Risk of bias risk of death Ritonavir searched standard care systematic review tested Treatment Trial trials variants [DOI] 10.1503/cmaj.220471 PMC 바로가기 [Article Type] Meta-Analysis
Maternal and neonatal safety outcomes after SAR-CoV-2 vaccination during pregnancy: a systematic review and meta-analysis임신 중 SAR-CoV-2 백신 접종 후 산모 및 신생아 안전성 결과: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-07-212022-09-11 Journal: BMC Pregnancy and Childbirth [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95%CI Analysis APGAR score bioRxiv Birth weight case-control studies Cochrane Library conducted controlled trials COVID-19 COVID-19 vaccine database died during pregnancy Evidence Fever FIVE Grey literature hemorrhage hospital Hospitalization inception incidence individual Maternal medRxiv Meta-analysis miscarriage Neonatal Newcastle-Ottawa Scale no effect no statistically significant difference outcome OVID patients postpartum hemorrhage Pregnancy problem problems puerperal puerperal fever Randomized controlled trial Randomized controlled trials risk risk of bia Safety SAR-CoV-2 searched square statistically significant difference systematic review vaccination Vaccine Web of Science [DOI] 10.1186/s12884-022-04884-9 PMC 바로가기 [Article Type] Meta-Analysis
Major candidate variables to guide personalised treatment with steroids in critically ill patients with COVID-19: CIBERESUCICOVID studyObservational Study Published on 2022-07-012022-10-04 Journal: Intensive care medicine [Category] 임상, [키워드] Administered administration affected age Analysis assessment Bacterial baseline benefit Care clinically Corticosteroid corticosteroid treatment Corticosteroids covariate COVID-19 COVID-19 patient Critically ill Critically ill patient Dexamethasone dosage dose doses of corticosteroid early administration Evidence failure higher risk hospitalisation ICU ICU admission ICUs Illness severity in-hospital mortality increased risk Inflammation information intensive care interaction term Invasive mechanical ventilation investigated Laboratory lower risk Major mechanical ventilation Modification Mortality multivariable analysis no effect nosocomial Observational cohort study organ damage Patient patients with COVID-19 performed personalised Pneumonia potential benefit Primary outcome Protective receiving severe coronavirus disease severity Significant SOFA Spanish steroid subgroup subgroups subgroups of patient symptom onset systemic corticosteroid Treatment use of corticosteroid variable with COVID-19 [DOI] 10.1007/s00134-022-06726-w PMC 바로가기 [Article Type] Observational Study