Awake prone positioning for non-intubated patients with COVID-19-related acute hypoxic respiratory failure: a systematic review based on eight high-quality randomized controlled trialsarticle Published on 2023-06-192024-09-05 Journal: BMC Infectious Diseases [Category] update2024, [키워드] acute hypoxic respiratory failure Awake prone positioning COVID-19 Non-intubated Randomized controlled trials systematic review [DOI] 10.1186/s12879-023-08393-8 PMC 바로가기 [Article Type] article
Prone position versus usual care in hypoxemic COVID-19 patients in medical wards: a randomised controlled trialarticle Published on 2023-06-172024-09-05 Journal: Critical Care [Category] update2024, [키워드] Awake prone position COVID-19 Hypoxemia Medical wards Non-intubated Respiratory failure spontaneous breathing [DOI] 10.1186/s13054-023-04529-z PMC 바로가기 [Article Type] article
Potential of FX06 to prevent disease progression in hospitalized non-intubated COVID-19 patients – the randomized, EU-wide, placebo-controlled, phase II study design of IXIONClinical Trial Published on 2022-08-192022-10-05 Journal: Trials [Category] SARS, 임상, [키워드] addition Administered Admission capillary Capillary leak Clinical management clinical study code coronavirus COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Deterioration disease Disease progression double-blinded drop-out Endothelial dysfunction Endpoint enrolled EudraCT Europe France FX06 Germany Hospital stay Hospitalization Hospitalized hospitalized patient Human ICU Inflammation intravenously Italy lack limitation Lithuania Lung function mammals Mild moderate multicentre Non-intubated occurred outbreak oxygen saturation Patient patient recruitment patients patients receiving placebo peptide per day Placebo placebo-controlled Portugal positive SARS-CoV-2 PCR Potential Prevent prevent disease progression primary endpoint problem proportion protocol randomization Randomized receiving recruitment reduce Romania SARS-CoV-2 secondary Spain stages standard care Study design subject survival systemic inflammation the WHO therapy while [DOI] 10.1186/s13063-022-06609-x PMC 바로가기 [Article Type] Clinical Trial
Does awake prone positioning prevent the use of mechanical respiratory support or death in COVID-19 patients on standard oxygen therapy hospitalised in general wards? A multicentre randomised controlled trial: the PROVID-19 protocol깨어 있는 엎드린 자세가 일반 병동에 입원한 표준 산소 요법을 받는 COVID-19 환자의 기계적 호흡 지원 또는 사망을 방지합니까? 다기관 무작위 대조 시험: PROVID-19 프로토콜Article Published on 2022-07-082022-09-11 Journal: BMJ Open [Category] COVID19(2023년), SARS, 임상, [키워드] acute respiratory distress acute respiratory distress syndrome approved ARDS Awake prone positioning body mass body mass index composite endpoint COVID-19 COVID-19 patient COVID-19 patients death death in COVID-19 decrease defined Ethics France hospitalised hypothesised hypoxaemia IMPROVE Infectious diseases Informed consent intervention group intubation investigator-initiated mechanical respiratory multicentre Non-intubated non-invasive ventilation Noninvasive ventilation Oxygenation Patient patients with ARDS peer-reviewed Prevent prone Prone position prone positioning protocol randomised randomised controlled receive registration number respiratory distress Respiratory distress syndrome respiratory infections responsible Safe severity Standard of care standard oxygen therapy Stratification submitted Support survival syndrome the ethics committee Treatment treatment failure Trial usual care usual care alone [DOI] 10.1136/bmjopen-2021-060320 PMC 바로가기 [Article Type] Article
Early administration of COVID-19 convalescent plasma with high titer antibody content by live viral neutralization assay is associated with modest clinical efficacy살아있는 바이러스 중화 분석에 의한 고역가 항체 함량을 가진 COVID-19 회복기 혈장의 조기 투여는 보통의 임상 효능과 관련이 있습니다Article Published on 2022-06-012022-09-11 Journal: American journal of hematology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] absolute reduction administration administration of CCP antibody Antibody titer benefit CCP clinical benefit Clinical efficacy convalescent plasma correlation COVID-19 COVID-19 convalescent plasma Cox regression death rate death rates determined by develop Dilution Efficacy evaluate evaluated Hospitalization hospitalized patient hospitalized patients inhibitory intubated patients multivariable Cox regression neutralized Neutralizing antibody titer Non-intubated non-intubated patient non-intubated patients Patient receiving Risk factors shown stratified titer transfused Treatment two groups Viral viral neutralization viral variant Viral variants was performed with COVID-19 [DOI] 10.1002/ajh.26531 PMC 바로가기 [Article Type] Article
Early versus late proning in non-intubated COVID-19 pneumoniaLetter Published on 2021-12-102022-11-01 Journal: Critical Care [Category] Coronavirus, SARS, [키워드] COVID-19 Non-intubated Pneumonia proning [DOI] 10.1186/s13054-021-03838-5 PMC 바로가기 [Article Type] Letter
Whole-lung low-dose radiation therapy (LD-RT) for non-intubated oxygen-dependent patients with COVID-19-related pneumonia receiving dexamethasone and/or remdesevir덱사메타손 및/또는 렘데세비르를 투여받는 COVID-19 관련 폐렴이 있는 삽관되지 않은 산소 의존 환자를 위한 전폐 저선량 방사선 요법(LD-RT)Article Published on 2021-12-012022-09-11 Journal: Radiotherapy and oncology : journal of the Europea [Category] SARS, 바이오마커, 비임상, 치료기술, [키워드] Adding addition Analysis animal model anti-inflammatory effect Anti-inflammatory effects Biomarkers biomarkers of inflammation breath C-reactive protein cardiac injury clinical clinical recovery Cohort Control controls COVID-19 COVID-19 patient creatine creatine kinase CRP declined Dexamethasone drug therapy drug treatment drug treatments febrile Hospitalization Inflammation Injury intubation Intubation rates low-dose Low-dose radiation Non-intubated outcome oxygen Oxygenation Patient patients evaluated Pneumonia predicted Predictive produced Prospective trial radiation therapy Radiographic Radiotherapy randomized trial receiving reduced reduction reduction in Significant significant differences subset survival therapy treated Treatment Trial [DOI] 10.1016/j.radonc.2021.10.003 PMC 바로가기 [Article Type] Article
Effectiveness of convalescent plasma therapy in eight non-intubated coronavirus disease 2019 patients in Indonesia: a case seriesCase Report Published on 2021-11-232022-10-30 Journal: Journal of Medical Case Reports [Category] COVID-19, MERS, SARS, [키워드] acid acute respiratory syndrome Administered age Antibody titer Case series case sery Clinical symptoms convalescent plasma Convalescent plasma therapy coronavirus coronavirus disease curative dose eight faster global pandemic Hospital admission illness onset improvement Indonesia Intubated Laboratory parameters median time Negative conversion Non-intubated occurred oxygen supplementation Patient patients plasma polymerase chain prevent disease progression RNA Safe severe adverse effect Symptom the patient therapy Thorax Treatment Vaccine [DOI] 10.1186/s13256-021-03059-y PMC 바로가기 [Article Type] Case Report
Multicenter validation of Early Warning Scores for detection of clinical deterioration in COVID-19 hospitalized patientsResearch article Published on 2021-11-012022-10-05 Journal: Medicina intensiva [Category] 치료기술, [키워드] 95%CI admitted to ICU AUROC calculated Clinical deterioration COVID-19 Critical care Early warning score evaluate hospital Hospital admission Hospitalization hospitalized patient ICU ICU admission index intensive care multicenter NEWS2 Non-intubated objective outcome Patient patients predict Predictive Result SARS-CoV-2 score setting transfer transferred variable [DOI] 10.1016/j.medin.2021.11.002 [Article Type] Research article
Inhaled high dose nitric oxide is a safe and effective respiratory treatment in spontaneous breathing hospitalized patients with COVID-19 pneumoniaResearch article Published on 2021-11-012022-10-05 Journal: Nitric oxide : biology and chemistry [Category] 치료법, [키워드] Acute kidney injury administration adverse event breathing COVID-19 COVID-19 patient COVID-19 patients determine died discharged patient Donor Effect effective evaluated feasibility Follow-up High dose High-dose hospital Hospitalization hospitalized patient Hypoxemia hypoxemic Inhaled inhibit intubation mechanical ventilation median multicenter nitric oxide Non-intubated occurred Oxygenation Patient patients patients with COVID-19 Pneumonia PPM readmission replication of SARS-CoV-2 required respiratory rate Result Safe selective subject treated patients Treatment Viral pneumonia with COVID-19 [DOI] 10.1016/j.niox.2021.08.003 [Article Type] Research article