nonsynonymous – Communicable Diseases Research

Progressive Evolutionary Dynamics of Gene-Specific ω Led to the Emergence of Novel SARS-CoV-2 Strains Having Super-Infectivity and Virulence with Vaccine Neutralization

Article

Published on 2024-06-072024-09-05
Journal: International Journal of Molecular Sciences [Category] update2024,

Rapid detection of SARS-CoV-2 variants of concern by single nucleotide polymorphism genotyping using TaqMan assays

Article

Published on 2022-12-012022-11-15
Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 변종, 치료기술,

[키워드] 95% CI Accuracy acute respiratory syndrome approach B.1.1.7 B.1.526 clinical setting Concordance coronavirus coronavirus disease 19 Coronavirus disease 19 (COVID-19) E484K evaluated genotyping mutations N501Y nasopharyngeal Negative predictive value New York City nonsynonymous patient population polymorphism positive positive sample predicted ranged Rapid Real-time reverse-transcription PCR residual RT-qPCR SARS-CoV-2 SARS-CoV-2 testing SARS-CoV-2 variant sensitivity Sequencing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) significantly lower single nucleotide specificity Spike protein submitted subset TaqMan TaqMan assay Thermofisher variant variants variants of concern were used WGS whole genome
[DOI] 10.1016/j.diagmicrobio.2022.115789 PMC 바로가기

Antibody escape and cryptic cross-domain stabilization in the SARS-CoV-2 Omicron spike protein

Article

Published on 2022-09-142022-11-15
Journal: Cell Host & Microbe [Category] SARS, 변종, 유전자 메커니즘, 진단,

Contrasting Patterns in the Early Stage of SARS-CoV-2 Evolution between Humans and Minks

Article

Published on 2022-09-012022-11-16
Journal: Molecular Biology and Evolution [Category] SARS, 변종,

Whole Exome Sequencing Identifies a Rare Mutation in NACAD as a Possible Cause of COVID orchitis in Brothers

Conference abstract

Published on 2022-04-012022-10-05
Journal: The journal of sexual medicine [Category] 변종,

[키워드] ACE2 ACE2 pathway Affect affected age amino acid change antigens average Blood body aches Brother cause cellular cellular entry chromosome 7 circulating controls cough COVID COVID-19 COVID-19 patient Critical current Cytokine storm DNA extraction Evidence examined Exome Extracellular Fever FIVE frameshift Frequency Genetic genetic susceptibility Genotype Human hypothese IgG Inflammation involved kidneys less liver Lungs men Mutation NACAD nonsynonymous objective organ Pain pathogenicity Patient patients PCR PCR positive performed plasma samples polymerase chain population prevalence Prevalence PROTECT R&D Systems report Result SARS CoV-2 SARS-CoV2 Sequencing Serum level soluble ACE2 sore throat subject susceptibility Symptom syndrome testicular pain Transport USA variant variants Vascular endothelium WES while with COVID-19
[DOI] 10.1016/j.jsxm.2022.01.068 [Article Type] Conference abstract

Impact of ADAR-induced editing of minor viral RNA populations on replication and transmission of SARS-CoV-2

SARS-CoV-2의 복제 및 전파에 대한 소수 바이러스 RNA 집단의 ADAR 유도 편집의 영향

423

Published on 2022-01-212022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 변종, 치료기술,

[키워드] accumulated ACE2 receptor acting acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADAR adenosine adenosine deaminase Amino acid amino acids analyzed binding change clinical sample clinical samples Consensus consensus sequence coronavirus correlated COVID-19 pandemic Deamination deep sequencing determine dominant early phase enzyme Enzymes European followed by Frequency guanine Impact incidence increasingly initial limit median Mortality mutated Mutation mutations nonsynonymous Patient patient cohort Population Presence prevalent Receptor binding domain receptor binding motif reduced Reflection Replication representing residue respiratory restrict retrieved RNA RNA deamination RNA mutation SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 RNA sequence severe acute respiratory syndrome Coronavirus Significance significantly spike gene Spike protein Substitution the SARS-CoV-2 genome the spike protein Transmissibility transmission of SARS-CoV-2 variants of SARS-CoV-2 Viral viral fitness viral infection Viral load viral replication Viral RNA
[DOI] 10.1073/pnas.2112663119 PMC 바로가기 [Article Type] 423

A short plus long-amplicon based sequencing approach improves genomic coverage and variant detection in the SARS-CoV-2 genome

Research Article

Published on 2022-01-132022-10-28
Journal: PLoS ONE [Category] COVID-19,

[키워드] Amplicon amplify Analysis Combined Coverage COVID-19 pandemic COVID-19 positive patients Deletion deletions E484K eight evaluated example final set fraction Genome Genome sequencing genomic hybrid IMPROVE insertion insertions interval intervals K417N Multiplex-PCR Mutation mutations N501Y nasopharyngeal swab specimen nonsynonymous ORF3a protein Patient positive control primer Primers Protein provide RNA SARS-CoV-2 SARS-CoV-2 lineage SARS‐CoV‐2 Sequencing sequencing approach significantly Single nucleotide variant SNVs spike gene synonymous the SARS-CoV-2 genome variant variants of concern Viral transmission virus genome
[DOI] 10.1371/journal.pone.0261014 PMC 바로가기 [Article Type] Research Article

Detection of A-to-I RNA Editing in SARS-COV-2

SARS-COV-2에서 A-to-I RNA 편집 검출

Article

Published on 2021-12-232022-09-10
Journal: Genes [Category] SARS, 유전자 메커니즘, 치료기술, 치료법, 치료제,

Updated SARS-CoV-2 single nucleotide variants and mortality association

업데이트된 SARS-CoV-2 단일 뉴클레오티드 변이체 및 사망률 연관성

Article

Published on 2021-12-012022-09-11
Journal: Journal of medical virology [Category] SARS, 변종, 진단,

[키워드] Affect age alteration Analysis association changed Clustering collected contributing to Critical D614G dominant feature Gender group hydrophobicity immune evasion incidence indicated intrinsic introduced logistic regression model male Mortality mortality risk mortality risk factor Mutation nonsynonymous nonsynonymous mutation nucleotide occur ORF1 ORF1ab ORF7a Patient Protein Protein conformation protein folding protein structure Region SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes significantly Single nucleotide variant single nucleotide variants single nucleotide variants. SNV SNVs spike subgroup surface area Transmission turn upstream Viral viral pathogenesis virulence
[DOI] 10.1002/jmv.27191 PMC 바로가기 [Article Type] Article

SARS-CoV-2 evolution in animals suggests mechanisms for rapid variant selection

동물에서의 SARS-CoV-2 진화는 신속한 변이체 선택을 위한 메커니즘을 제안합니다

423

Published on 2021-10-292022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료법,

[키워드] accelerate accumulating amplified animal Animal host animal hosts animal model animals arising cats Cell culture change changes in companion animals Contact contact with COVID-19 patients Cross-species transmission deer dominant variant Evolution ferret ferrets fixation Frequency functional Genes Genome hamster hamsters highlight Host host adaptation hosts Households Human human-to-animal transmission humans in vitro in vivo Infection inoculation Lineage Live virus mammalian mechanism mink molecular nonsynonymous nucleocapsid observation ORF8 patients phenotype plasticity Reinfection repeated residue residues reveal SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 variant SARS-CoV-2 variants sequence sequenced Significance species spillover stock Substitution substitutions switching Transmission USA-WA1/2020 variant Vero Vero Cell Viral viral evolution viral lineages viral variant Viral variants virus viruses widespread wild animal wild animals wild-type with COVID-19
[DOI] 10.1073/pnas.2105253118 PMC 바로가기 [Article Type] 423