Effect of oral antiseptics in reducing SARS-CoV-2 infectivity: evidence from a randomized double-blind clinical trialRandomized Controlled Trial Published on 2022-12-012022-10-05 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 임상, [키워드] antiseptic mouthwashe cell cultures cetylpyridinium chloride clinical trial COVID-19 COVID-19 patients Culture double-blind Effect evaluated Evidence in vitro in vivo indicated Infectivity Mouthwash mouthwashe mouthwashes not affected Placebo placebo-controlled clinical trial quantitative PCR Randomized reduce reduced reducing Saliva salivary SARS-CoV-2 shown significantly tested viability viral infectivity Viral load Viral transmission virucidal [DOI] 10.1080/22221751.2022.2098059 PMC 바로가기 [Article Type] Randomized Controlled Trial
A six-month study of anti-SARS-CoV-2 BNT162b2 mRNA vaccination: A comparative analysis of essential trace elements and anti-RBD IgG sera levelsArticle Published on 2022-12-012022-11-15 Journal: Journal of trace elements in medicine and biology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] (Post)vaccinal immunity adaptive Analysis analyzed Anti-RBD IgG anti-SARS-CoV-2 anti-SARS-CoV-2 IgG Antibody detection Antibody titers association biochemical BNT162b2 mRNA BNT162b2 mRNA vaccine changes in Concentration Cu Effect elevated Essential Essential trace elements expressed female follow-up period glycoprotein healthy HEK-293 human serum IgG antibody Immunity immunization investigated mRNA vaccine not affected observation period produced producing Protein purified RBD Receptor binding domain remained SARS-CoV-2 sera serum specific IgG antibody spike T cells Total Trace element vaccination Vaccine Volunteer women Zn [DOI] 10.1016/j.jtemb.2022.127079 PMC 바로가기
Tracking SARS-CoV-2 in rivers as a tool for epidemiological surveillanceArticle Published on 2022-11-202022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] activities Analysis Bacteria Caldera can be used characterized collected Concentration Contamination contributed correlated correlation COVID-19 COVID-19 cases discharge epidemiological epidemiological situation epidemiological surveillance evaluate fecal health authorities Human Human tracers impacted limit microbiologically negatively affected normalization normalized not affected plant quantified receiving reflected reported river Rivers impacted by wastewater RNase P RT-qPCR Salta SARS-CoV-2 SARS-CoV-2 surveillance significant increase similarity Support Surveillance target Viral concentration water quality [DOI] 10.1016/j.scitotenv.2022.157707 PMC 바로가기
Risk of reinfection and disease after SARS-CoV-2 primary infection: Meta-analysisArticle Published on 2022-10-012022-11-16 Journal: European Journal of Clinical Investigation [Category] COVID19(2023년), SARS, 변종, [키워드] baseline cohort study COVID-19 criteria Critical disease evaluate evaluated Frequency Gender health care need individuals Infection lethal disease Meta-analysis natural immunity no substantial difference not affected omicron Omicron variant performed pooled rate Primary infection proportion reached Reinfection remained Repository risk SARS-CoV-2 searched severity stratified subject subjects subset vaccination vaccine dose viral strain were recorded [DOI] 10.1111/eci.13845 PMC 바로가기
Impact of the COVID-19 pandemic in the lipid control of the patients that start PCSK9 inhibitorsArticle Published on 2022-09-012022-10-05 Journal: Clínica e investigación en arteriosclerosis : publicación oficial de la [Category] 임상, [키워드] adverse event Analysis baseline value cardiovascular disease changes in Clinical practice clinical trials Cognitive function Colesterol-LDL COVID-19 COVID-19 pandemic Effectiveness effectiveness-safety Eficacia-seguridad flu-like symptom Follow-up Impact Inhibidores de la PCSK9 inhibitor inhibitors injection intensity LDL cholesterol LDL-cholesterol material myalgia not affected not significant pandemic Patient patients treated PCSK9 PCSK9 inhibitors. Pharmacist reduction statin the patient the primary endpoint treated was reduced worsening [DOI] 10.1016/j.arteri.2022.01.003 PMC 바로가기 [Article Type] Article
High Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Household Transmission Rates Detected by Dense Saliva Sampling고밀도 타액 샘플링으로 감지된 고중증급성호흡기증후군 코로나바이러스 2(SARS-CoV-2) 가구 전파율Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Analysis attack rate calculated capillary blood capillary blood samples children collected coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Dense enrolled highest household household transmission Households independent index case individuals infection control investigated majority measure nasopharyngeal swabs not affected NPs oropharyngeal swab oropharyngeal swabs pandemic phylogenetic analyses polymerase chain polymerase chain reaction positive Rate Real-time monitoring repeated reported Research respiratory Saliva saliva sample saliva samples sampling SAR SARS-CoV-2 SARS-CoV-2 transmission secondary attack rate secondary case secondary cases serology serum serum sample severe acute respiratory syndrome Coronavirus study inclusion suggested Swab tested understanding vaccination was performed Whole genome sequencing [DOI] 10.1093/cid/ciac261 PMC 바로가기 [Article Type] Article
Targeted escape of SARS-CoV-2 in vitro from monoclonal antibody S309, the precursor of sotrovimabArticle Published on 2022-08-242022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] ACE2 ACE2 binding ACE2 binding site Amino acid angiotensin-converting enzyme 2 antibody Cell cell entry class conserved domain endocytosis Entry epitope escaped Evolution Evolution of SARS-CoV-2 fusion immune Immune escape immunological in vitro infections inhibit SARS-CoV-2 Interaction monoclonal monoclonal antibody not affected pathogenicity plasticity precursor Receptor-binding domain replicated S309 SARS-CoV-2 Sotrovimab susceptible the spike protein vaccination viral strain wild-type SARS-CoV-2 [DOI] 10.3389/fimmu.2022.966236 PMC 바로가기
COVID-19 mRNA booster vaccine induces transient CD8+ T effector cell responses while conserving the memory pool for subsequent reactivationCOVID-19 mRNA 부스터 백신은 일시적인 CD8+ T 효과기 세포 반응을 유도하는 동시에 후속 재활성화를 위해 메모리 풀을 보존합니다Article Published on 2022-08-082022-09-11 Journal: Nature Communications [Category] 변종, 진단, 치료기술, [키워드] activated analyzed boost booster vaccination Booster vaccine Breakthrough infection breakthrough infections CD8 CD8+ Cell conserved COVID-19 COVID-19 vaccination Delta dose effector cell elicit followed by Immunity immunization individual induce memory mRNA mRNA vaccine Neutralizing antibody response neutralizing antibody responses not affected omicron recall receiving response robust stem cell subsequent T cell T cell response T cell responses T cells T memory cells vaccination variants of concern waning immunity [DOI] 10.1038/s41467-022-32324-x PMC 바로가기 [Article Type] Article
Characterization of SARS-CoV-2 Escape Mutants to a Pair of Neutralizing Antibodies Targeting the RBD and the NTDRBD 및 NTD를 표적으로 하는 한 쌍의 중화 항체에 대한 SARS-CoV-2 탈출 돌연변이의 특성화Article Published on 2022-07-252022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] active immunization Affect antibodies antibody binding Cell culture characterization Clinical use Cluster Combination Efficacy escape escape mutant escape mutants escape mutation gene segments Genetic human immunoglobulin identify immunization immunization strategies Immunoglobulin indicate lead mice monoclonal monoclonal antibodies monoclonal antibody more difficult Mutation mutations neutralization Neutralization assay Neutralizing Neutralizing antibodies neutralizing antibody neutralizing monoclonal antibodies neutralizing monoclonal antibody nine not affected NTD pair passage pseudotype RBD RBD mutations reduced SARS-CoV-2 SARS-CoV-2 escape mutations SARS-CoV-2 variant SARS-CoV-2 variants selected Spike protein targeting the RBD the spike protein variable region variant variants variants of concern VoC [DOI] 10.3390/ijms23158177 PMC 바로가기 [Article Type] Article
Worse Disease Prognosis Is Associated to an Increase of Platelet-Derived Extracellular Vesicles in Hospitalized SARS-CoV-2 Patients더 나쁜 질병 예후는 입원한 SARS-CoV-2 환자에서 혈소판 유래 세포외 소포의 증가와 관련이 있습니다Article Published on 2022-07-072022-09-11 Journal: Disease Markers [Category] COVID19(2023년), SARS, 치료기술, [키워드] applied Biomarker Blood circulating Cohort COVID-19 enrolled Evolution EVs extracellular vesicle Extracellular vesicles flow cytometry healthy controls heparin Hospital admission Hospitalization human diseases increase Italy not affected occurred outcome Patient patients Platelet predict reducing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patients steroid Steroids suggested the disease Treatment viral infections WHO guidelines [DOI] 10.1155/2022/8074655 PMC 바로가기 [Article Type] Article