COVID-19 breakthrough infections and humoral immune response among BNT162b2 vaccinated healthcare workers in Malaysia말레이시아에서 BNT162b2 백신을 접종한 의료 종사자의 COVID-19 획기적인 감염 및 체액성 면역 반응Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] 95% CI affected age Anti-S1 Anti-spike antibody Antibody Response antibody titres association Asymptomatic Asymptomatic individuals blood sample Blood samples BNT162b2 booster vaccination breakthrough Breakthrough infection breakthrough infections collected COVID-19 COVID-19 infection delta variant detectable domain geometric mean geometric mean titre GMT HCWs healthcare healthcare worker Healthcare workers humoral humoral immune response Humoral immunity IgG IgG assay individual individuals Infection investigated Malaysia not different notable outcome Participants prospective cohort study Protein response significantly significantly higher Support symptomatic the antibody response vaccination Vaccine vaccine doses waned was measured [DOI] 10.1080/22221751.2022.2065936 PMC 바로가기 [Article Type] Article
Glycyrrhizin through liquorice intake modulates ACE2 and HMGB1 levels-A pilot study in healthy individuals with implications for COVID-19 and ARDSArticle Published on 2022-10-172022-11-15 Journal: PLoS ONE [Category] 치료제, [키워드] ACE2 ACE2 expression acute respiratory distress alarmin Analysis angiotensin-converting enzyme 2 Antiviral ARDS ARDS patient baseline baseline levels blood sample cause cellular change collected coronavirus disease COVID-19 enrolled enzyme-linked immunosorbent exhibit expression glycyrrhizin healthy individual healthy volunteer HMGB1 hospitalised COVID-19 patient hospitalised patient immunomodulatory property implication in healthy individual in healthy individuals individual individuals liquorice material Mild modulate Non-COVID-19 not different Patient patients pilot study Plasma HMGB1 Potential treatment pro-inflammatory receptor ACE2 reduced reduction in Respiratory disease significantly significantly higher syndrome viral entry were measured with mild disease [DOI] 10.1371/journal.pone.0275181 PMC 바로가기
Safety, immunogenicity, and immune persistence of two inactivated COVID-19 vaccines replacement vaccination in China: An observational cohort studyArticle Published on 2022-09-162022-11-15 Journal: Vaccine [Category] SARS, 진단, [키워드] administration Adverse reaction All participant anti-SARS-CoV-2 approved BBIBP-CorV can be used China Complete control group COVID-19 COVID-19 vaccine Cytopathic effect dose doses first dose geometric mean concentration geometric mean titer GMCs GMTs healthy immune persistence immunogenicity Immunoglobulin inactivated Inactivated vaccine Mild mitigate moderate NAb National not different not significantly different observation Observational cohort study Pragmatic regimens replacement Replacement vaccine Safety safety profile SARS-CoV-2 strain second dose sera severity Standard subject vaccination WHO [DOI] 10.1016/j.vaccine.2022.08.037 PMC 바로가기
Brain dural arteriovenous fistulas in the COVID-19 Era: A warning and rationale for associationResearch article Published on 2022-09-012022-10-05 Journal: Clinical neurology and neurosurgery [Category] 바이오마커, 변종, 진단, [키워드] age Artery association average Brain dural arteriovenous fistula cardiovascular risk factors cerebral Cerebral venous thrombosis Clinical features Cohort conducted connection correlation COVID-19 COVID-19 infection COVID-19 vaccine diagnosed dural sinus thrombosis Hemorrhagic incidence increase in interval males Neurovascular not different objective Pathogenesis pathogenic Patient post-COVID-19 vaccination prevaccination prothrombotic radiological raise Research Result retrospective risk factor Sex significant increase significantly higher thrombotic treated vaccination Vaccine Vaccines Vascular venous Warning with COVID-19 [DOI] 10.1016/j.clineuro.2022.107367 [Article Type] Research article
Maternal and neonatal outcomes of pregnancies with COVID-19 after medically assisted reproduction: results from the prospective COVID-19-Related Obstetrical and Neonatal Outcome StudyObservational Study Published on 2022-09-012022-10-05 Journal: American journal of obstetrics and gynecology [Category] 임상, [키워드] 95% confidence interval acute respiratory syndrome Admission adverse outcome adverse outcomes Affect age assisted reproduction body mass index Cohort cohort study Complication contributed coronavirus COVID-19 death disorder disorders evaluate the effect fertility treatment gestation gestational diabete hemorrhage hypertensive incidence increased risk independent Infection intensive care Logistic regression Maternal Maternal outcomes morbidity Neonatal Neonatal outcomes not different nulliparity Observational cohort study Odds ratio outcome Pneumonia pregnancies Pregnancy Preterm birth Registered risk risk factor SARS-CoV-2 SARS-COV-2 infection Stillbirth Treatment with COVID-19 women [DOI] 10.1016/j.ajog.2022.04.021 PMC 바로가기 [Article Type] Observational Study
Age- and sex-based changes in spike protein antibody status after SARS-CoV-2 vaccination and effect of past-infection in healthcare workers in OsakaArticle Published on 2022-08-262022-11-15 Journal: BMC Infectious Diseases [Category] SARS, 진단, [키워드] age Age group All participant antibody antibody status Antibody titre assays association Blood changes in different time point examined follow-up time healthcare worker investigated men not different nucleocapsid protein Nucleocapsid protein antibody participant Peripheral blood positive positive correlation Protein provided reduction in SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 vaccination second vaccination Seven Sex shown significant negative correlation significantly higher spike Spike protein Spike protein antibody. t-test titre vaccination were assessed women Yao [DOI] 10.1186/s12879-022-07695-7 PMC 바로가기
Immunologic phenotype of patients with long-COVID syndrome of 1-year durationArticle Published on 2022-08-242022-11-15 Journal: Frontiers in Immunology [Category] SARS, 치료기술, [키워드] 95% confidence interval Adjusted analysis adjusted hazard ratio analyzed antibody Antibody Response antibody response, antinuclear antibodies (ANA) Autoimmunity Biomarker blood sample C-reactive protein cellular Cellular immune response cellular immune responses chronic inflammation COVID-19 COVID-19 symptom D-dimer detectable discharged Follow-up Frequency groups hospital hospitalized COVID-19 patient humoral humoral immune response ICU admission immune immune response Immunologic include Inflammation information Level Long COVID long-COVID mitigate myalgia neutralizing antibody no difference not different One year pathophysiology Patient phenotype positive Post-COVID-19 syndrome Prospective questionnaire reported SARS-CoV-2 antibody serological Smokers Symptom symptomatic patient Symptomatic patients syndrome T-cell T-cell immune response WHO severity score women [DOI] 10.3389/fimmu.2022.920627 PMC 바로가기
Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection Associates With Unstable Housing and Occurs in the Presence of Antibodies중증 급성 호흡기 증후군 코로나바이러스 2 재감염은 불안정한 주택과 연관되어 항체 존재 시 발생Article Published on 2022-08-242022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, [키워드] Analysis analyzed antibody Antibody neutralization Associate associations Boston center Comorbidity convalescent coronavirus 2 coronavirus disease COVID-19 COVID-19 severity defined enzyme-linked immunosorbent assay Factor greater groups had more homeless Humoral response identify Immunoglobulin individual Infection initial interval marker negative test neutralization not different occur patients with SARS-CoV-2 persistent shedding polymerase chain Positive test Presence Primary infection pseudovirus Reinfection respiratory Respiratory Coronavirus reverse transcription SARS-CoV-2 SARS-CoV-2 antibodies severity significantly higher subset treatment history Unstable virus were used [DOI] 10.1093/cid/ciab940 PMC 바로가기 [Article Type] Article
De-isolation of vaccinated COVID-19 health care workers using rapid antigen detection test신속한 항원 검출 테스트를 사용하여 백신 접종된 COVID-19 의료 종사자의 격리 해제Article Published on 2022-08-012022-09-11 Journal: Journal of infection and public health [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] antigen detection approach Asymptomatic COVID-19 COVID-19 disease COVID-19 vaccination De-isolation described Diagnosis diagnosis of COVID-19 dose evaluate Evidence HCW HCWs Health care Health care worker health care workers increasingly Isolation Mild disease mild infection not different omicron Patient positive Rapid rapid antigen test required retrospective cohort study SARS-CoV-2 virus severe COVID-19 disease single center Symptom Vaccine variants viral kinetics viral shedding while with mild disease [DOI] 10.1016/j.jiph.2022.06.020 PMC 바로가기 [Article Type] Article
Difference in safety and humoral response to mRNA SARS-CoV-2 vaccines in patients with autoimmune neurological disorders: the ANCOVAX study자가면역 신경계 장애 환자에서 mRNA SARS-CoV-2 백신에 대한 안전성 및 체액 반응의 차이: ANCOVAX 연구Article Published on 2022-08-012022-09-11 Journal: Journal of Neurology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] 95% CI ANC anti-CD20 anti-SARS-CoV-2 anti-SARS-CoV-2 IgG Anti-spike antibody antibody levels Antibody Response Assessing Autoimmune Autoimmune neurological disorders BNT162b2 BNT162b2 vaccine Clinical practice condition Control difference dose Effect evaluated fingolimod humoral Humoral response IgG immune therapy immunotherapies Immunotherapy incidence increased risk IQR Local longitudinal study mAb median age mRNA mRNA vaccine mRNA vaccines mRNA-1273 mRNA-1273 vaccine Multiple multiple sclerosis neurological Neurological status not different of BNT162b2 Patient patients rate ratio Receptor binding domain reduced Relapse Safe SARS-CoV-2 SARS-CoV-2 vaccine Sars-Cov2-mRNA vaccine. second dose seroconversion rate side Side effects systemic reaction systemic reactions the antibody response Treatment vaccination Vaccine were assessed [DOI] 10.1007/s00415-022-11142-7 PMC 바로가기 [Article Type] Article