Pharmacogenomic considerations for repurposing of dexamethasone as a potential drug against SARS-CoV-2 infectionSARS-COV-2 감염에 대한 잠재적 약물로서 덱사메타손의 용도를 다른 용도를위한 약물 유전전증 고려 사항Review Published on 2021-06-042022-08-31 Journal: Personalized Medicine [Category] MERS, SARS, 신약개발, 유전자 메커니즘, [키워드] Abstract agonist analgesic effect analgesic effects anti-inflammatory drug benefit changes in chronic patients clinically Control Corticosteroid COVID-19 COVID-19 case Critical cure CYP3A5 Dexamethasone drug drug response Effect effort evaluate Factor Genetic genetic factors Genetic variation glucocorticoid Glucocorticoid receptors Health Organization immunomodulatory drugs individual individuals inherent involved metabolism metabolome NR3C1 NR3C2 outcome pathway Patient patients pharmacogenetics pharmacokinetic pharmacokinetics Potential treatment Randomized controlled trials receptors recovery RECOVERY trial reduce mortality Regulatory reported SARS-CoV-2 SARS-COV-2 infection severe COVID-19 patient severe COVID-19 patients therapy Transcriptome United Kingdom Usage World Health Organization [DOI] 10.2217/pme-2020-0183 PMC 바로가기 [Article Type] Review
Plasma IL-6 levels following corticosteroid therapy as an indicator of ICU length of stay in critically ill COVID-19 patientsArticle Published on 2021-03-152022-10-04 Journal: Cell Death Discovery [Category] 임상, 치료제, [키워드] acute respiratory distress administration of corticosteroid Admission Alveolar macrophages ARDS association average BALF Care Cell cell type clinical trial Corticosteroid corticosteroid therapy COVID-19 patient COVID-19 severity Critically ill CRS Cytokine release syndrome death Dexamethasone driven by Drug development Endothelial cell Examining glucocorticoid ICU IL-6 IL-6 expression IL-6 level IL-6 levels Interim Mortality NR3C1 outcome oxygen Patient plasma Predictive markers receive receptor Regulation severe COVID-19 patient single-cell RNA-seq smooth muscle cells survival syndrome Ventilation viral infection [DOI] 10.1038/s41420-021-00429-9 PMC 바로가기 [Article Type] Article