Structural Reshaping of the Zinc-Finger Domain of the SARS-CoV-2 nsp13 Protein Using Bismuth(III) Ions: A Multilevel Computational StudyArticle Published on 2022-10-032022-11-16 Journal: Inorganic chemistry [Category] COVID19(2023년), SARS, 변종, [키워드] analyses anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity classical decrease degrade domain Effect Efficacy Evidence evidenced extension feature Helicase hydrophobic immune Interaction Ion MD simulations MIF Modification molecular molecular interaction non-structural protein nsp12 protein nsp13 Occurrence pandemic Protein provide Research responsible SARS-COV-2 infection the SARS-CoV-2 the vaccine therapeutic strategy variants [DOI] 10.1021/acs.inorgchem.2c02685 PMC 바로가기
In Vitro Selection of Remdesivir-Resistant SARS-CoV-2 Demonstrates High Barrier to Resistance렘데시비르 내성 SARS-CoV-2의 체외 선택은 내성에 대한 높은 장벽을 보여줍니다Article Published on 2022-07-192022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 치료제, [키워드] 50% effective concentration active site acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 barrier coronavirus in vitro increase in introduced Lineage Nsp12 Nsp12 polymerase nsp12 protein passage polymerase Protein remained Remdesivir resistance resistance. SARS-CoV-2 SARS-CoV-2 virus Selection [DOI] 10.1128/aac.00198-22 PMC 바로가기 [Article Type] Article
The anti-HCV, Sofosbuvir, versus the anti-EBOV Remdesivir against SARS-CoV-2 RNA dependent RNA polymerase in silicoSARS-CoV-2 RNA 의존성 RNA 중합효소에 대한 항-HCV, Sofosbuvir 대 항-EBOV Remdesivir in silicoArticle Published on 2022-02-012022-09-11 Journal: Molecular diversity [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] active form affecting Anti-HCV antiviral drugs approved binding binding affinity binding energy binding mechanism clinically comparable complexes Control coronavirus diseases Coronaviruses COVID-19 disease docked docking drug Drug repurposing Effectiveness Efficacy FDA HCV Health help in silico inhibitor Interaction Ligand limit molecular docking molecular dynamics Molecular dynamics simulation Nsp12 nsp12 protein nucleotide polymerases positive control Protein RdRP Remdesivir reported RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp SARS-CoV-2 RNA sofosbuvir Sofosbuvir. target tested the binding affinity the SARS-CoV-2 therapeutic target three-dimensional structure used to evaluate Viral protein [DOI] 10.1007/s11030-020-10178-z PMC 바로가기 [Article Type] Article
Genomic characterization of SARS‐CoV‐2 isolates from patients in Turkey reveals the presence of novel mutations in spike and nsp12 proteinsResearch Article Published on 2021-07-162022-10-04 Journal: Journal of medical virology [Category] MERS, SARS, 변종, 치료기술, [키워드] Affect amino acid changes Analysis assigned B.1 B.1.1 clade Critical D614G deletions distribution full‐length genome functional Genome genome sequence genomic geographical areas Illumina implication individual information isolate Lineage Missense MONITOR mortality rates Mutation mutation analysis nasopharyngeal next‐generation sequencing novel Nsp12 nsp12 protein P323L pangolin pathogenicity Patient Phylogenetic Phylogenetic tree platform processed provide reveal RNA SARS‐CoV‐2 SARS‐CoV‐2 genome SARS‐CoV‐2 sequence sequenced Sequencing sequencing data specimen specimens Spread strain subsequent synonymous tested therapeutic Transmissibility transmission pathway Treatment Turkey university Vaccine development variant variants Virology virulent virus was determined was performed [DOI] 10.1002/jmv.27188 PMC 바로가기 [Article Type] Research Article
Coronavirus replication–transcription complex: Vital and selective NMPylation of a conserved site in nsp9 by the NiRAN-RdRp subunit530 Published on 2021-02-092022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] activity acute respiratory syndrome antiviral drug arterivirus Cell culture cellular complex conserved Coronaviridae coronavirus Coronavirus replication Critical cytidine dependent on domain Evidence family Coronaviridae functional generate HCoV-229E homolog Hypothesis in vitro Interaction Ion M pro marker monophosphate mutant N terminus N-terminal Nidovirale nidovirus NiRAN Nsp12 nsp12 protein Nsp9 Nsps nucleotide nucleotidyltransferase observation polyprotein protease Protein proteolytic provide RdRps released Replication reported residue RNA polymerase RNA synthesis RNA viruses RNA-dependent RNA polymerase selective sequence shown Significance subunit suggested transfer transferase activity virus virus replication Vital [DOI] 10.1073/pnas.2022310118 PMC 바로가기 [Article Type] 530