Structure-Based Virtual Screening for Methyltransferase Inhibitors of SARS-CoV-2 nsp14 and nsp16Article Published on 2024-05-152024-09-05 Journal: Molecules [Category] update2024, [키워드] MTase inhibitors nsp14 nsp16 SARS-CoV-2 Structure-based virtual screening [DOI] 10.3390/molecules29102312 PMC 바로가기 [Article Type] Article
Cheminformatics approach to identify andrographolide derivatives as dual inhibitors of methyltransferases (nsp14 and nsp16) of SARS-CoV-2Article Published on 2024-04-292024-09-05 Journal: Scientific Reports [Category] update2024, [키워드] andrographolide Cheminformatics COVID-19 Drug discovery Drug discovery and development natural compounds nsp14 nsp16 Screening [DOI] 10.1038/s41598-024-58532-7 PMC 바로가기 [Article Type] Article
A universal fluorescence polarization high throughput screening assay to target the SAM-binding sites of SARS-CoV-2 and other viral methyltransferasesAntimicrobial Agents Published on 2023-05-052024-09-05 Journal: Emerging Microbes & Infections [Category] update2024, [키워드] High Throughput Screening inhibitor methyltransferase nsp14 SARS-CoV-2 [DOI] 10.1080/22221751.2023.2204164 PMC 바로가기 [Article Type] Antimicrobial Agents
SARS-CoV-2 Nsp14 protein associates with IMPDH2 and activates NF-κB signalingArticle Published on 2022-09-132022-11-16 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] activate Activation acute respiratory syndrome bortezomib caused contribute coronavirus COVID-19 patients cytokine Host identify IL-6 IL-8 IMPDH2 Infection inhibitor Interaction knockdown lung tissue sample mechanism mycophenolic acid NF-κB NF-κB activation NF-κB signaling nsp14 nuclear translocation occurred p65 pro-inflammatory cytokines promote Protein proteomic regulate ribavirin SARS-CoV-2 SARS-CoV-2 infected cells SARS-COV-2 infection the SARS-CoV-2 upregulation viral infection viral replication [DOI] 10.3389/fimmu.2022.1007089 PMC 바로가기
Expression Profile and Localization of SARS-CoV-2 Nonstructural Replicase Proteins in Infected CellsArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome analyzed antibody antiviral strategy caused coronavirus COVID-19 pandemic determine diagnosis of SARS-CoV-2 diagnostics different time points diffusion dsRNA expression expression profile foci function Gene Expression immunofluorescence assay indicated Infection Localization mechanism mechanisms N protein nonstructural protein nsp13 nsp14 Nsp15 NSP2 Nsp3 Nsp9 Postinfection potential molecular profile Protein protein-protein interaction Proteins provide regulated replicase replicase proteins Replication responsible SARS-CoV-2 SARS-CoV-2-infected cell subcellular distribution subcellular localization suggested viral growth virus replication [DOI] 10.1128/spectrum.00744-22 PMC 바로가기
SARS-CoV-2 nsp14 Exoribonuclease Removes the Natural Antiviral 3′-Deoxy-3′,4′-didehydro-cytidine Nucleotide from RNASARS-CoV-2 nsp14 엑소리보뉴클레아제는 RNA에서 천연 항바이러스성 3'-데옥시-3',4'-디데하이드로-시티딘 뉴클레오타이드를 제거합니다Article Published on 2022-08-162022-09-11 Journal: Viruses [Category] SARS, 변종, 유전자 메커니즘, 치료제, [키워드] 3'-dCTP analogues Antiviral antiviral drug Antiviral effect biochemically caused Chain terminator COVID-19 cytidine 5'-monophosphate ddhCTP Efficacy enzyme ExoN Exoribonuclease facilitate feature global pandemic innate immune response mechanism monophosphate natural natural antiviral non-structural protein nsp14 nucleoside nucleoside analogue nucleotide nucleotide analogues nucleotides produced Proofreading RdRP Remove Replication RNA RNA genome RNA polymerase RNA synthesis RNA-dependent RNA polymerase SARS-CoV-2 susceptible termination the SARS-CoV-2 viral infections Viral RNA [DOI] 10.3390/v14081790 PMC 바로가기 [Article Type] Article
Roles and functions of SARS-CoV-2 proteins in host immune evasion숙주 면역 회피에서 SARS-CoV-2 단백질의 역할과 기능Review Published on 2022-08-082022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료법, [키워드] accessory protein accessory proteins activator acute respiratory syndrome acute respiratory syndrome coronavirus coronavirus described ENCODE evade Frame function functions Genome Host host immune system IFN-β IFNs immune immune evasion inhibiting interferon interferons IRF3 mechanism mechanisms NF-κB nine non-structural protein non-structural proteins nsp1 Nsp12 nsp13 nsp14 Nsp15 nsp5 NSP6 NSP8 Nsps nuclear nuclear translocation Open reading frame ORF10 ORF3b ORF6 ORF8 Orf9b Perspective Phosphorylation Protein Regulatory role SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Signaling STAT2 STATs structural proteins suppress TBK1 Transcription type I type I and III interferons variety Viral protein Viral proteins [DOI] 10.3389/fimmu.2022.940756 PMC 바로가기 [Article Type] Review
Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activityArticle Published on 2022-08-042023-07-09 Journal: Structure (London, England : 1993) [Category] COVID19(2023년), [키워드] coronavirus Methylation methyltransferase nsp10 nsp14 proof-reading SAH SARS-CoV-2 Structure XRD [DOI] 10.1016/j.str.2022.04.014 PMC 바로가기
SARS-CoV-2 virus NSP14 Impairs NRF2/HMOX1 activation by targeting Sirtuin 1SARS-CoV-2 바이러스 NSP14는 Sirtuin 1을 표적으로 하여 NRF2/HMOX1 활성화를 손상시킵니다Article Published on 2022-08-012022-09-11 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] activate Activation acute respiratory distress acute respiratory distress syndrome antioxidant defense system antiviral activity ARDS Biliverdin catalytic domain cell type COVID-19 pandemic Cytokine storms death Defense Evidence Factor Genetic HMOX1 Host host defense inhibit interact mechanism metabolite MOST Nrf2 nsp14 oxidative stress pathway producing regulated respiratory distress Respiratory failure Respiratory virus infections SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 virus significantly SIRT1 sirtuin suppressed syndrome Viral protein [DOI] 10.1038/s41423-022-00887-w PMC 바로가기 [Article Type] Article
The global succinylation of SARS-CoV-2-infected host cells reveals drug targetsSARS-CoV-2에 감염된 숙주 세포의 세계적인 숙시닐화는 약물 표적을 드러낸다Article Published on 2022-07-262022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료법, 치료제, [키워드] Analysis Antiviral antiviral drug antiviral drug target antiviral effects antiviral therapies Caco-2 Caco-2 cells causative agent cellular cellular pathway cellular pathways conserved COVID-19 COVID-19 pandemic demonstrated drug target enzyme Evolution highlighting Host host cell host protein inhibit inhibitor Interaction mechanism membrane protein Membrane proteins metabolic pathways Modification nsp14 overexpressed promote Protein Quantitative regulated Regulatory reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid SIRT5 sirtuin succinylproteomics. variants Viral proteins virus replication [DOI] 10.1073/pnas.2123065119 PMC 바로가기 [Article Type] Article