A SARS-CoV-2 NSP7 homolog of a Treg epitope suppresses CD4+ and CD8+ T cell memory responsesImmunology Original Research Published on 2023-11-242024-09-05 Journal: Frontiers in immunology [Category] update2024, [키워드] immune camouflage immunogenicity Nsp7 SARS-CoV-2 Tolerance Tregitope [DOI] 10.3389/fimmu.2023.1290688 PMC 바로가기 [Article Type] Immunology Original Research
Molecular basis for the repurposing of histamine H2-receptor antagonist to treat COVID-19COVID-19 치료를 위한 히스타민 H2 수용체 길항제의 용도 변경을 위한 분자 기반Article Published on 2022-08-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] Coronavirus, 신약개발, 유전자 메커니즘, [키워드] activities Analysis antagonist binding affinity carried Cimetidine complex coronavirus COVID-19 determine docking effective Efficacy Famotidine gene target high stability Histamine Ligand mechanism mechanism of action molecular basis molecular docking molecular dynamic simulation molecular dynamics Molecular dynamics simulation Nizatidine non-structural protein non-structural proteins Novel coronavirus Nsp3 Nsp7 Nsp9 Nsps Potential treatment preliminary report Ranitidine Result selected stability targets treat Treatment viral replication was performed [DOI] 10.1080/07391102.2021.1873191 PMC 바로가기 [Article Type] Article
Design and various in silico studies of the novel curcumin derivatives as potential candidates against COVID-19 -associated main enzymesCOVID-19 관련 주요 효소에 대한 잠재적 후보로서 새로운 커큐민 유도체의 설계 및 다양한 in silico 연구Article Published on 2022-06-012022-09-11 Journal: Computational biology and chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro acute respiratory syndrome ADME Analysis Anti-inflammatory antioxidant Antiviral antiviral drug antiviral drugs Area binding binding score candidate caused Combination contagious contagious disease coronavirus coronavirus disease Coronaviruses COVID-19 Curcumin derivative disease docking drug drug design drugs Effectiveness enzyme Enzymes expected in silico inhibitor inhibitors Ligand MD simulation MD simulations Mechanics MM-PBSA molecular molecular docking studies Molecular dynamic Molecular mechanics Novel coronavirus novel coronavirus disease Nsp15 Nsp7 patients performed pharmacokinetic PLPro Protein protein complex residue Safe SARS-CoV-2 SARS-CoV-2 virus Severe acute respiratory syndrome shown Simulation spike surface surface area the SARS-CoV-2 virus therapeutic Toxicity was determined [DOI] 10.1016/j.compbiolchem.2022.107657 PMC 바로가기 [Article Type] Article
Adenovirus 5 Vectors Expressing SARS-CoV-2 ProteinsSARS-CoV-2 단백질을 발현하는 아데노바이러스 5 벡터Article Published on 2022-04-272022-09-11 Journal: mSphere [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Adenovirus animal model animal models causative agent caused Cell cell line cell lines cellular Community coronavirus coronavirus protein COVID-19 COVID-19 pandemic effort Engagement etiology evaluate Evolution Express expressed facilitate flexibility fusion host cell immune system evasion mechanism molecular Molecular biology N protein Novel coronavirus Nsp12 Nsp7 NSP8 Outbreaks pandemic qRT-PCR Quantitative reagent reagents Receptor binding domain Research researcher resource reverse transcriptase Rules of engagement SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 proteins shifting subcellular localization targets the N protein the S protein the SARS-CoV-2 to be done transcriptase variant variants variety vector Viral proteins Viral vector viral vectors virus Virus-host interaction Virus-host interactions western blotting [DOI] 10.1128/msphere.00998-21 PMC 바로가기 [Article Type] Article
Insights into Binding of Single-Stranded Viral RNA Template to the Replication-Transcription Complex of SARS-CoV-2 for the Priming Reaction from Molecular Dynamics Simulations분자 역학 시뮬레이션의 프라이밍 반응을 위한 SARS-CoV-2의 복제-전사 복합체에 대한 단일 가닥 바이러스 RNA 템플릿 결합에 대한 통찰력Article Published on 2022-03-152022-09-11 Journal: Biochemistry [Category] COVID19(2023년), SARS, 치료법, [키워드] bind carried complex cryo-EM structure de novo distribution Dynamics electrostatic electrostatic interactions Evidence include insight molecular molecular dynamics Nsp12 Nsp7 NSP8 nucleotide nucleotides oligomerization primer priming reaction Replication replication-transcription complex responsible RNA RNA polymerase RNA-dependent RNA polymerase RTC SARS-CoV SARS-CoV-2 secondary structure significantly Simulation single-stranded ssRNA stem-loop subunit synthesis tail Template viral genome Viral RNA viral RNAs viral transcription [DOI] 10.1021/acs.biochem.1c00755 PMC 바로가기 [Article Type] Article
Indomethacin-based PROTACs as pan-coronavirus antiviral agents범 코로나바이러스 항바이러스제로서의 인도메타신 기반 PROTACArticle Published on 2021-12-152022-09-11 Journal: European journal of medicinal chemistry [Category] SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addition anti-inflammatory drug Anti-SARS-CoV-2 Activity Antiviral antiviral activity antiviral agent Antiviral agents antiviral potency Chimera class coronavirus Coronavirus-2 CoVs demonstrated develop early stage example host protein human CoVs indicated indomethacin infected Vero E6 cells inhibit inhibit SARS-CoV-2 interact knowledge mechanism mechanism of action Nsp7 PGES-2 prostaglandin prostaglandin E PROTAC Protein proteolysis proteomic study Replication reported SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 strains Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Support synthesis targeting the SARS-CoV-2 Vero E6 VERO E6 cells [DOI] 10.1016/j.ejmech.2021.113814 PMC 바로가기 [Article Type] Article
Anti-SARS-CoV-2 IgG responses are powerful predicting signatures for the outcome of COVID-19 patientsAnti-SARS-CoV-2 IgG 반응은 COVID-19 환자의 결과에 대한 강력한 예측 신호입니다Article Published on 2021-11-262022-09-12 Journal: Journal of advanced research [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, [키워드] accessory protein Admission antibody association assumed Biomarker clinical information Clinical management Clinical outcome Comorbidities correlated COVID-19 COVID-19 mortality COVID-19 patient COVID-19 patients Cox proportional hazard demographics Disease progression disease severity Evidence global pandemic hospitalized COVID-19 patient identify IgG IgG antibody IgG response IgG responses implication Laboratory laboratory biomarker magnitude Microarray non-structural protein Non-structural/accessory protein nsp1 nsp10 Nsp7 NSP8 ORF3b Orf9b outcome outcomes Patient patient death patients positive rate Predicting signature predictive power Protein RdRP SARS-CoV-2 SARS-CoV-2 proteome SARS-CoV-2 specific antibody serum severity Severity of disease survivor symptoms onset was used [DOI] 10.1016/j.jare.2021.11.014 PMC 바로가기 [Article Type] Article
Potential Molecular Mechanisms of Rare Anti-Tumor Immune Response by SARS-CoV-2 in Isolated Cases of Lymphomas림프종의 분리 된 경우에서 SARS-COV-2에 의한 희귀 항 종양 면역 반응의 잠재적 분자 메커니즘Article Published on 2021-09-252022-09-01 Journal: Viruses [Category] SARS, 유전자 메커니즘, 진단, [키워드] anti-tumor immune response anti-tumor immunotherapy Apoptosis approach B-cell binding binding site Cancer CD27 CD45 cell proliferation classical Complete Complete Remission complex component domain Extracellular follicular Follicular lymphoma gamma-tubulin ring complex Hodgkin lymphoma induce inhibit initial interact interacting residues internalization Isolated lymphoma lymphoproliferative disorders M pro M protein membrane microtubule molecular mechanism monoclonal antibodies monoclonal antibody motif NF-kB nivolumab nsp10 Nsp7 oncogenesis ORF3a ORF3a protein PD-1 Pembrolizumab Potential Protein Proteins receptor Remission reported response responsible SARS-CoV-2 SARS-COV-2 infection Signaling the SARS-CoV-2 therapeutic potential TRADD TUBG1 virus [DOI] 10.3390/v13101927 PMC 바로가기 [Article Type] Article
Concise Update on Genomics of COVID-19: Approach to Its latest Mutations, Escalated Contagiousness, and Vaccine ResistanceReview Article Published on 2021-09-152022-10-31 Journal: Global Medical Genetics [Category] COVID-19, [키워드] acute respiratory distress Amino acid calreticulin canonical cause caused Cell changes in Chinese Clinical features complex connection coronavirus COVID-19 COVID-19 pandemic diagnostics Epidemiology genomic Genomics genomics of virus help histocompatibility complex Host hydrophobicity immune system Infectious disease inhibit intrinsic less membrane MHC-I Modification molecular multifunctional N-linked glycosylation Novel coronavirus novel coronavirus disease Nsp7 nucleus oligosaccharide outlined pandemic positive Protein proteomics Replication rate resistance response RNA genome SARS-CoV-2 sequence STAT structures syndrome transcription factor transfer translocated Treatment Vaccine development viral outbreak Viral protein virus [DOI] 10.1055/s-0041-1725143 PMC 바로가기 [Article Type] Review Article
SARS-CoV-2 Proteins Bind to Hemoglobin and Its MetabolitesSARS-CoV-2 단백질은 헤모글로빈과 그 대사산물에 결합합니다Article Published on 2021-08-212022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Adsorption affinity column Analysis analyzed approaches bind binding caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 domain explain FIVE hematological heme hemin hemoglobin identify in silico analysis in vitro inhibitory effect Interaction M metabolite Microarray motif motifs N N protein N-terminal domain Nsp3 Nsp7 NTD nucleoprotein peptide peptides Plaque assay Protein protein–protein binding Proteins proteomic Proteomic analysis proteomics protoporphyrin RBD RBD region receptor recruit recruitment Replication respiratory S protein SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2 spike sequence severe acute respiratory syndrome Coronavirus spike Spike protein suppressed the N protein the RBD the S protein the spike protein these compound these compounds Vero cells Viral viral replication virus was used [DOI] 10.3390/ijms22169035 PMC 바로가기 [Article Type] Article