An ncRNA transcriptomics-based approach to design siRNA molecules against SARS-CoV-2 double membrane vesicle formation and accessory genesarticle Published on 2023-12-122024-09-05 Journal: BMC Infectious Diseases [Category] update2024, [키워드] Accessory genes gene silencing ncRNA Non-structural genes Nsps Open Reading frame ORF SARS-CoV-2 siRNA [DOI] 10.1186/s12879-023-08870-0 PMC 바로가기 [Article Type] article
The mechanism of RNA capping by SARS-CoV-2 Research Published on 2022-08-092022-10-05 Journal: Nature [Category] SARS, 유전자 메커니즘, [키워드] Analysis Antiviral complex COVID-19 domain exonuclease facilitate functional GDP genetics group Host immune Interaction mechanism methyltransferase N terminus nidovirus non-structural protein Nsp12 Nsp9 Nsps required residue RNA RNA genome SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 RNA structures transfer translation treat Viral proteins [DOI] 10.1038/s41586-022-05185-z [Article Type] Research
Roles and functions of SARS-CoV-2 proteins in host immune evasion숙주 면역 회피에서 SARS-CoV-2 단백질의 역할과 기능Review Published on 2022-08-082022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료법, [키워드] accessory protein accessory proteins activator acute respiratory syndrome acute respiratory syndrome coronavirus coronavirus described ENCODE evade Frame function functions Genome Host host immune system IFN-β IFNs immune immune evasion inhibiting interferon interferons IRF3 mechanism mechanisms NF-κB nine non-structural protein non-structural proteins nsp1 Nsp12 nsp13 nsp14 Nsp15 nsp5 NSP6 NSP8 Nsps nuclear nuclear translocation Open reading frame ORF10 ORF3b ORF6 ORF8 Orf9b Perspective Phosphorylation Protein Regulatory role SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Signaling STAT2 STATs structural proteins suppress TBK1 Transcription type I type I and III interferons variety Viral protein Viral proteins [DOI] 10.3389/fimmu.2022.940756 PMC 바로가기 [Article Type] Review
Molecular basis for the repurposing of histamine H2-receptor antagonist to treat COVID-19COVID-19 치료를 위한 히스타민 H2 수용체 길항제의 용도 변경을 위한 분자 기반Article Published on 2022-08-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] Coronavirus, 신약개발, 유전자 메커니즘, [키워드] activities Analysis antagonist binding affinity carried Cimetidine complex coronavirus COVID-19 determine docking effective Efficacy Famotidine gene target high stability Histamine Ligand mechanism mechanism of action molecular basis molecular docking molecular dynamic simulation molecular dynamics Molecular dynamics simulation Nizatidine non-structural protein non-structural proteins Novel coronavirus Nsp3 Nsp7 Nsp9 Nsps Potential treatment preliminary report Ranitidine Result selected stability targets treat Treatment viral replication was performed [DOI] 10.1080/07391102.2021.1873191 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Delta variant isolates from vaccinated individualsSARS-CoV-2 Delta 변이체는 예방접종을 받은 개인에서 분리됩니다.Article Published on 2022-06-042022-09-11 Journal: BMC Genomics [Category] COVID19(2023년), SARS, 변종, [키워드] addition Affect circulating Cluster collected conformational change COVID-19 cytosolic Delta Delta B.1.617.2 delta variant Disruption genetic diversity Genome sequencing Genomic analysis hydrophobic immune evasion induce isolate isolates Lineage Mutation mutations Non-synonymous mutation Nsp15 Nsps ORF1 ORF1b ORF7a ORF8 Oxford Nanopore MinION polar position positive sample predominant premature stop codon Protein SARS-CoV-2 SARS-CoV-2 delta SARS-CoV-2 virus SARS-CoV-2 viruses side chain Spike protein the spike protein transmembrane protein Transmissibility Transport vaccinated individual vaccinated individuals Vaccine variant variant of concern virus was performed Whole genome sequencing [DOI] 10.1186/s12864-022-08652-z PMC 바로가기 [Article Type] Article
In silico study of potential antiviral activity of copper(II) complexes with non-steroidal anti-inflammatory drugs on various SARS-CoV-2 target proteins다양한 SARS-CoV-2 표적 단백질에 대한 비스테로이드성 항염증제와 구리(II) 복합체의 잠재적 항바이러스 활성에 대한 실리코 연구Article Published on 2022-06-012022-09-11 Journal: Journal of inorganic biochemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] 3C–like cysteine main protease antiviral activity Antiviral agents biological activity Cancer cell line clonixin complex complexes copper coronavirus 2 Coronavirus 2019 COVID-19 cysteine cytotoxic cytotoxic activity distribution drug-likeness evaluated fenoprofen FIVE ibuprofen in silico in silico predictive tools. in vitro ligands loxoprofen M pro metabolism molecular docking studies non-steroidal anti-inflammatory drug Non-steroidal anti-inflammatory drugs non-structural protein non-structural proteins nsp10 Nsp16–Nsp10 2′–O–methyltransferase complex Nsps pandemic Papain-like protease Papain–like protease performed pharmacokinetic pharmacokinetic data physicochemical PLPro Predictive protease Protein RdRP respiratory RNA RNA-dependent RNA polymerase RNA–dependent RNA polymerase SARS-CoV-2 SARS–CoV–2 target proteins Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus silico predictions target protein target proteins therapeutic target Toxicity [DOI] 10.1016/j.jinorgbio.2022.111805 PMC 바로가기 [Article Type] Article
Exploring the Catalytic Mechanism of the RNA Cap Modification by nsp16-nsp10 Complex of SARS-CoV-2 through a QM/MM ApproachArticle Published on 2021-12-282022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] 2′-O methylation acute respiratory syndrome antiviral therapy approach assumed binding calculated CAP catalytic Catalytic mechanism cellular mRNA complex coronavirus Coronavirus replication Critical Drug discovery enzyme evaluated expected free energy Host innate immune mechanism Methylation molecular analysis mRNA nsp16-nsp10 Nsps PROTECT Protein QM/MM RNA SARS-CoV-2 TS stabilization viral replication virus [DOI] 10.3390/ijms23010300 PMC 바로가기 [Article Type] Article
NMR‐Based Analysis of Nanobodies to SARS‐CoV‐2 Nsp9 Reveals a Possible Antiviral Strategy Against COVID‐19SARS -COV -2 NSP9에 대한 나노 바디의 NMR 기반 분석Research Article Published on 2021-10-272022-09-10 Journal: Advanced Biology [Category] MERS, SARS, 치료제, [키워드] Against Analysis antiviral strategy applied B‐cell characterized complex coronavirus coronavirus disease COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 diagnostic epitope Epitopes expressed host cell identify immunoassay immunoassays implication Lineage molecular molecular dynamics monomeric nanobodies nanobody New NMR spectroscopy nonstructural protein nonstructural proteins Nsp9 Nsps nuclear magnetic resonance oligomerization Patient Protein purified recognize Replication required Result RTC Saliva saliva samples SARS‐CoV‐2 SARS‐CoV‐2 Strategy supported therapeutic Transcription unique Viral viral replication [DOI] 10.1002/adbi.202101113 PMC 바로가기 [Article Type] Research Article
Insight into the emerging role of SARS-CoV-2 nonstructural and accessory proteins in modulation of multiple mechanisms of host innate defense숙주 선천적 방어의 다중 메커니즘의 조절에서 SARS-COV-2 비 구조 및 보조 단백질의 새로운 역할에 대한 통찰력Review Published on 2021-10-012022-09-01 Journal: Bosnian Journal of Basic Medical Sciences [Category] 진단, [키워드] accessory protein accessory proteins Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Antigen presentation Apoptosis array caused complex coronavirus coronavirus disease Coronavirus disease-19 COVID-19 Defense disease severity disrupting effector molecules Elimination ENhance favor Frame Health Host host immune system IFN-I IFN-I signaling immune evasion immune response immunomodulators Infection Infectious disease Inflammatory mediators insight interferon mediators modulate modulation molecular multiple mechanism nonstructural protein nonstructural proteins Nsps ORFs pathogenic pathway persistence proinflammatory respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Signaling Therapies therapy type I interferon Vaccine Viral viral adaptation virus [DOI] 10.17305/bjbms.2020.5543 PMC 바로가기 [Article Type] Review
Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate InhibitorsSAM 경쟁 억제제를 사용한 시험관 내 SARS-CoV-2 Nsp14의 SAM 결합 부위 조사 선택적 이중 기질 억제제 개발 가이드Article Published on 2021-10-012022-09-11 Journal: SLAS discovery : advancing life sciences R & D [Category] SARS, 유전자 메커니즘, 치료제, [키워드] adenosylmethionine Antiviral binding cause competitive inhibitor Consequences coronavirus COVID-19 COVID-19 pandemic Developing DNA evade Guanosine guide Healthcare system Healthcare systems house Human immune system inhibited inhibitor library lysine mechanism of action Methylation methyltransferase NSP nsp14 Nsps optimization other coronaviruses path Probing Protein provided RNA SAM SARS-CoV-2 SARS-CoV-2 virus selective significant difference significant differences Site the disease these compound these compounds Viral RNA [DOI] 10.1177/24725552211026261 PMC 바로가기 [Article Type] Article