Impact of basic psychological support on stigma and mental well-being of people with disabilities due to leprosy and lymphatic filariasis: a proof-of-concept studyOriginal Article Published on 2023-12-202024-09-05 Journal: International Health [Category] update2024, [키워드] disability mental well-being NTD Peer support Stigma [DOI] 10.1093/inthealth/ihad096 PMC 바로가기 [Article Type] Original Article
Binding and neutralizing abilities of antibodies towards SARS-CoV-2 S2 domainSARS-CoV-2 S2 도메인에 대한 항체의 결합 및 중화 능력Article Published on 2022-11-302022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody B.1.1.7 B.1.351 B.1.617.2 B.1.621 binding binding activity carried conserved convalescent patient coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 determined by domain ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated Evidence Immune escape immune protection mAb mAbs MERS MERS-CoV Middle East Middle East respiratory syndrome Middle East respiratory syndrome Coronavirus molecular monoclonal antibodies monoclonal antibody N Terminal N terminal domain NAbs Neutralization assay neutralization assay. Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody NTD P.1 Protein pseudo-virus RBD Receptor binding domain reported Research respiratory Result S protein S proteins S2 protein S2 subunit SARS-CoV SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 S SARS-CoV-2 S2 SARS-CoV-2 WT Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly specific antibodies subunit target targets terminal Vaccine design variant variants wild-type [DOI] 10.1080/21645515.2022.2055373 PMC 바로가기 [Article Type] Article
Naturally occurring spike mutations influence the infectivity and immunogenicity of SARS-CoV-2Article Published on 2022-11-012022-11-15 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] A570D A701V addition Affect affected antibodies antigenicity B.1.1.529 B.1.1.7 B.1.1.7 lineage B.1.351 B.1.617.2 BALB/c mice binding circulating cross-neutralization activity D1118H decrease Del Delta determine DNA vaccine Effects Efficiency elicited humoral immune response immune evasion immunized immunogen in vitro investigated K417N L18F Lineage Mutation NAbs Naturally neutralization Neutralizing Neutralizing antibodies neutralizing antibody NTD omicron opposite overcome P681H Pseudotyped viruses reduced S982A SARS-CoV-2 SARS-CoV-2 variant sera significantly increased single mutation single mutations spike mutation T cell T cell responses T-cell Response T716I tested the RBD Transmissibility unlikely Vaccine vaccine immunogenicity variants of concern viral entry viral infectivity VoC VOCs was determined weakened [DOI] 10.1038/s41423-022-00924-8 PMC 바로가기
Genomic Epidemiology and Serology Associated with a SARS-CoV-2 R.1 Variant Outbreak in New JerseyArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory syndrome antibody antibody resistance attack rate B.1.351 B.1.526 Care caused characteristic Clinical use collected Community Complete coronavirus COVID-19 Critical E484K mutation Evidence Examining exhibit exhibited hcp Health highlight individual infected individuals Infection Inpatient Lineage loss of activity monoclonal antibody Mutation N-terminal domain neutralization capacity Neutralizing antibody response neutralizing capacity New nosocomial NTD outbreak P.1 Patient plasma positive professional professionals proportion pseudovirus psychiatric facility Receptor binding domain reported reverse transcription robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant sera Spike protein Symptom symptomatic COVID-19 disease tested the SARS-CoV-2 the United State treat vaccinated individual vaccinated individuals vaccination Vaccine variant variants of concern VOCs wild type [DOI] 10.1128/mbio.02141-22 PMC 바로가기
Correlation of SARS-CoV-2 Viral Neutralizing Antibody Titers with Anti-Spike Antibodies and ACE-2 Inhibition among Vaccinated IndividualsArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 진단, [키워드] ACE-2 ACE2 ACE2 binding analyzed Angiotensin converting enzyme-2 Anti-RBD IgG Anti-spike anti-spike antibody anti-Spike IgG antibody binding blood collection BNT162b2 calculated collected Concentration correlated correlation correlation coefficient correlation coefficients COVID-19 COVID-19 antibody demonstrated dosing interval examined Fisher group groups IgG individual inhibition interval intervals labor-intensive measure mRNA mRNA-1273 vaccines Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers NTD Participants performed RBD Sample SARS-CoV-2 Secondary analyses Spearman correlation coefficient subgroup tested the median the vaccine titer vaccinated individual vaccination Vaccine vaccinee vaccinees Validity viral neutralization wild-type with COVID-19 women [DOI] 10.1128/spectrum.01315-22 PMC 바로가기
Evolutionary remodelling of N-terminal domain loops fine-tunes SARS-CoV-2 spikeArticle Published on 2022-10-062022-11-16 Journal: EMBO Reports [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] analyses Analysis antigenic variation complex COVID-19 Critical Deletion exacerbated fine-tune flexible functional Health Host Immunity mechanism membrane fusion Modification modulate Mutation N-terminal domain NTD omicron polymorphism receptor engagement remained responsible reveal Sarbecoviruses SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant spike spike glycoprotein spike stability variant variants Variation Viral transmission virus entry [DOI] 10.15252/embr.202154322 PMC 바로가기
Omicron (BA.1) and sub-variants (BA.1.1, BA.2, and BA.3) of SARS-CoV-2 spike infectivity and pathogenicity: A comparative sequence and structural-based computational assessmentSARS-CoV-2 스파이크 감염성 및 병원성의 오미크론(BA.1) 및 하위 변이체(BA.1.1, BA.2 및 BA.3): 비교 시퀀스 및 구조 기반 계산 평가Article Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 binding acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin BA.1 BA.2 BA.3 BA1.1 bind binding affinity bronchial cells computational tool computational tools contribute contributing to coronavirus COVID-19 Deleterious domain Effectiveness electrostatic expressed Factor hACE2 higher affinity human ACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 hydrogen hydrogen bonds indicate Interaction K417N less lineages Lower respiratory tract lung mutated Mutation mutations N-terminal domain N501Y negative NTD omicron Omicron variant pathogenicity positive predicted Q498 RBD RBM receptor receptors residue residues Salt Bridge SARS-CoV-2 SARS-CoV-2 spike sequence severe acute respiratory syndrome Coronavirus significantly Spike protein Spread surface potential T478K the RBD the spike protein thought Transmission transmission potential variant variants wild-type [DOI] 10.1002/jmv.27927 PMC 바로가기 [Article Type] Article
A SARS-CoV-2 oral vaccine development strategy based on the attenuated Salmonella type III secretion systemArticle Published on 2022-10-012022-11-15 Journal: Journal of Applied Microbiology [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] administration Analysis antibody Antigen antigens attenuated Salmonella ΔhtrA-VNP Bacterial caused CD44 CD69 COVID-19 vaccine cytometric cytosol delivery effective element elicited Express expression Flow fluorescence microscopy Heterologous IgA IgG in vitro increase in Macrophage mixed bacterial preparations. mutant N-protein NTD Oral vaccine pathogenicity phenotype Plasmid promoter RBD S-protein Safe Salmonella SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 vaccine screened secrete secretion shown Significance Significant significant increase SPI-2 strain T-cell activation T3SS the vaccine type III Vaccine was used [DOI] 10.1111/jam.15720 PMC 바로가기
Structural interactions of phytoconstituent(s) from cinnamon, bay leaf, oregano, and parsley with SARS-CoV-2 nucleocapsid protein: A comparative assessment for development of potential antiviral nutraceuticalsArticle Published on 2022-10-012022-11-15 Journal: Journal of food biochemistry [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] affinity Antiviral antiviral agent apigenin binding binding domain binding interaction biological activity C-terminal Cancer Cancer cells candidate carried cell line cell lines cells Cinnamomum cinnamon complex complexes components Compound computational analysis computational approach CTD cytotoxicity death drug candidate Druglikeness effective Efficacy evaluate evaluated examined greater HPLC in silico in vitro in vivo Interaction lack less molecular molecular dynamics MTT N-terminal Naturally NTD nucleocapsid nutraceutical oregano Origanum outcome parsley. plant predicted profile Prophylactic Protein provided Research responsible RNA SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 nucleocapsid protein stability symptomatic targets therapeutic therapeutic drug therapy Toxicity treating COVID-19 Treatment virus was determined was performed worsened [DOI] 10.1111/jfbc.14262 PMC 바로가기
Receptor-Binding Domain (RBD) Antibodies Contribute More to SARS-CoV-2 Neutralization When Target Cells Express High Levels of ACE2Article Published on 2022-09-162022-11-15 Journal: Viruses [Category] SARS, 진단, [키워드] ACE2 ACE2 binding ACE2 expression Affect antibodies antibody Cell cell receptor domain Effectiveness expression Infection lentivirus Level monoclonal monoclonal antibody N-terminal domain neutralization Neutralization assay neutralize Neutralizing activity neutralizing antibody neutralizing antibody epitopes NTD polyclonal antibody polyclonal human sera pseudovirus Pseudovirus neutralization assays RBD Region SARS-CoV-2 Serum Neutralization spike epitope subset target target cell target cell receptor expression. target cells the RBD therapeutic [DOI] 10.3390/v14092061 PMC 바로가기