State-of-the-art and emerging antivirals for chronic hepatitis B infectionReview Published on 2022-12-012023-06-13 Journal: Expert opinion on pharmacotherapy [Category] [DOI] 10.1080/14656566.2022.2144219 PMC 바로가기 [Article Type] Review
Synthesis and Anticancer and Antiviral Activities of C-2′-Branched ArabinonucleosidesArticle Published on 2022-10-192022-11-15 Journal: International Journal of Molecular Sciences [Category] [DOI] 10.3390/ijms232012566 PMC 바로가기
Optimization of the Prodrug Moiety of Remdesivir to Improve Lung Exposure/Selectivity and Enhance Anti-SARS-CoV-2 ActivityArticle Published on 2022-09-222022-11-15 Journal: Journal of medicinal chemistry [Category] [DOI] 10.1021/acs.jmedchem.2c00758 PMC 바로가기
t6A and ms2t6A Modified Nucleosides in Serum and Urine as Strong Candidate Biomarkers of COVID-19 Infection and SeverityArticle Published on 2022-09-032022-11-15 Journal: Biomolecules [Category] [DOI] 10.3390/biom12091233 PMC 바로가기
Pharmacokinetics of ß-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection중증 급성 호흡기 증후군 코로나바이러스 2 감염 환자의 비혈장 구획에서 프로드럭 Molnupiravir의 모체 뉴클레오사이드인 ß-d-N4-Hydroxycytidine의 약동학Clinical Trial Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] [DOI] 10.1093/cid/ciac199 PMC 바로가기 [Article Type] Clinical Trial
SARS-CoV-2 nsp14 Exoribonuclease Removes the Natural Antiviral 3′-Deoxy-3′,4′-didehydro-cytidine Nucleotide from RNASARS-CoV-2 nsp14 엑소리보뉴클레아제는 RNA에서 천연 항바이러스성 3'-데옥시-3',4'-디데하이드로-시티딘 뉴클레오타이드를 제거합니다Article Published on 2022-08-162022-09-11 Journal: Viruses [Category] [DOI] 10.3390/v14081790 PMC 바로가기 [Article Type] Article
PIKfyve-specific inhibitors restrict replication of multiple coronaviruses in vitro but not in a murine model of COVID-19PIKfyve 특정 억제제는 시험관 내에서 여러 코로나바이러스의 복제를 제한하지만 COVID-19의 쥐 모델에서는 제한하지 않습니다Article Published on 2022-08-122022-09-11 Journal: Communications Biology [Category] [DOI] 10.1038/s42003-022-03766-2 PMC 바로가기 [Article Type] Article
Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanismsSARS-CoV-2 RNA 의존성 RNA 중합효소의 돌연변이는 별개의 메커니즘으로 렘데시비르에 대한 내성을 부여합니다Article Published on 2022-08-032022-09-11 Journal: Science Translational Medicine [Category] [DOI] 10.1126/scitranslmed.abo0718 PMC 바로가기 [Article Type] Article
Synthesis, antimicrobial, molecular docking and molecular dynamics studies of lauroyl thymidine analogs against SARS-CoV-2: POM study and identification of the pharmacophore sitesSARS-CoV-2에 대한 라우로일 티미딘 유사체의 합성, 항균, 분자 도킹 및 분자 역학 연구: POM 연구 및 약전 부위 식별Article Published on 2022-08-012022-09-11 Journal: Bioorganic chemistry [Category] [DOI] 10.1016/j.bioorg.2022.105850 PMC 바로가기 [Article Type] Article
A Systematic Study on the Optimal Nucleotide Analogue Concentration and Rate Limiting Nucleotide of the SARS-CoV-2 RNA-Dependent RNA PolymeraseSARS-CoV-2 RNA 의존성 RNA 중합효소의 최적 뉴클레오티드 유사체 농도 및 속도 제한 뉴클레오티드에 대한 체계적인 연구Article Published on 2022-07-272022-09-11 Journal: International Journal of Molecular Sciences [Category] [DOI] 10.3390/ijms23158302 PMC 바로가기 [Article Type] Article