The First 5′-Phosphorylated 1,2,3-Triazolyl Nucleoside Analogues with Uracil and Quinazoline-2,4-Dione Moieties: A Synthesis and Antiviral EvaluationArticle Published on 2022-09-212023-06-23 Journal: Molecules [Category] 신종인플루엔자, [키워드] 1,2,3-Triazole antivirals click chemistry Influenza virus Nucleoside analogues nucleotides. [DOI] 10.3390/molecules27196214 PMC 바로가기
Molnupiravir for the treatment of COVID-19Article Published on 2022-07-012023-07-10 Journal: Drugs of today (Barcelona, Spain : 1998) [Category] COVID19(2023년), [키워드] Anti-SARS-CoV-2 Agents antiviral drugs COVID-19 molnupiravir Nucleoside analogues RNA-dependent RNA polymerase (RdRp) inhibitors Viral replication inhibitors. [DOI] 10.1358/dot.2022.58.7.3419558 PMC 바로가기
A Nanopore Based Molnupiravir SensorArticle Published on 2022-05-272023-07-08 Journal: ACS Sensors [Category] COVID19(2023년), [키워드] molnupiravir Mycobacterium smegmatis porin A Nucleoside analogues programmable nanoreactors single-molecule chemistry. [DOI] 10.1021/acssensors.2c00447 PMC 바로가기
Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2 Research Published on 2022-02-072022-10-05 Journal: Nature [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] amplified Antiviral antiviral activity antiviral drugs antiviral nucleoside analogue antiviral therapeutics antivirals approved candidate clinically COVID-19 death develop drug effort evade flu-like symptoms Host human respiratory cell identify in vitro in vivo individual Infection inhibit inhibitor Live virus molnupiravir nucleoside analogue Nucleoside analogues Remdesivir replicate RNA virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus screened strain subset threat Vaccine Vaccines variant [DOI] 10.1038/s41586-022-04482-x [Article Type] Research
Nucleotide Analogues Bearing a C2′ or C3′-Stereogenic All-Carbon Quaternary Center as SARS-CoV-2 RdRp Inhibitors †Article Published on 2022-01-172022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] addition analogue Bearing center COVID-19 described epoxidation functional glycosylation inhibitor N -glycosylation NTP nucleoside analogue Nucleoside analogues quaternary stereocenter RdRP reaction Reactions RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp these compound triphosphorylation virus [DOI] 10.3390/molecules27020564 PMC 바로가기 [Article Type] Article
Synthesis of Nucleoside-like Molecules from a Pyrolysis Product of Cellulose and Their Computational Prediction as Potential SARS-CoV-2 RNA-Dependent RNA Polymerase InhibitorsArticle Published on 2022-01-042022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] ADME prediction anhydrosugar applied approved atomic average binding pocket carried catalytic Cellulose complex coronavirus correlations COVID-19 docking fluctuation GS-441524 in silico indicated inhibitors of SARS-CoV-2 Interaction metabolite Mitsunobu reaction Modification molecular docking Molecular dynamics simulation molecule nucleoside Nucleoside analogues Potential prediction product pyrolysis RdRP Remdesivir RNA RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV2 Seven supported synthesis these compound Treatment [DOI] 10.3390/ijms23010518 PMC 바로가기 [Article Type] Article
Current treatment strategies for COVID-19Review Published on 2021-12-152023-06-14 Journal: Molecular medicine reports [Category] MERS, SARS, [키워드] antibodies Chinese herbal medicine Coronavirus disease 2019 Nucleoside analogues RNA-dependent RNA polymerase severe acute respiratory syndrome coronavirus 2 [DOI] 10.3892/mmr.2021.12498 PMC 바로가기 [Article Type] Review
Reductionism Ad Absurdum: The Misadventures of Structural Biology in the Time of Coronavirus환원주의 Ad Absurdum: 코로나바이러스 시대의 구조생물학의 불행Article Published on 2021-11-122022-09-11 Journal: ACS Infectious Diseases [Category] SARS, 치료기술, 치료제, [키워드] analogues approach Biology characterization consequence Course COVID-19 pandemic detect exchange faster global scientific community mechanism misunderstanding nucleoside nucleoside analogue Nucleoside analogues pace RdRP recommendation Reductionism Remdesivir Research researcher response RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RNA structural biology time [DOI] 10.1021/acsinfecdis.1c00492 PMC 바로가기 [Article Type] Article
Controversies in Treating Chronic Hepatitis B virus: The Role of Hepatitis B Virus DNA and Surface Antigen TiterReview Published on 2021-11-012023-06-13 Journal: Clinics in Liver Disease [Category] B형 간염, [키워드] HBsAg HBV DNA interferon Nucleoside analogues Phase change qHBsAg. Stopping therapy Treatment [DOI] 10.1016/j.cld.2021.06.005 PMC 바로가기 [Article Type] Review
A review on the interaction of nucleoside analogues with SARS-CoV-2 RNA dependent RNA polymerase뉴클레오사이드 유사체와 SARS-CoV-2 RNA 의존성 RNA 중합효소의 상호작용에 대한 고찰Review Published on 2021-06-302022-09-11 Journal: International journal of biological macromolecules [Category] SARS, 신약개발, 치료제, [키워드] Antiviral antiviral drugs approved clinical development computational analysis CoV COVID-19 CoVs drug Efficacy ExoN ExoN proofreading Favipiravir human CoV human CoVs Infection information inhibitor Interaction lack nucleoside nucleoside analogue Nucleoside analogues outbreak platform preserved RdRP Remdesivir Repurposed drug ribavirin RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp SARS-CoV-2 RNA SARS-CoV-2. Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 sofosbuvir tenofovir Vaccine [DOI] 10.1016/j.ijbiomac.2021.03.112 PMC 바로가기 [Article Type] Review