Synthesis of Natural and Sugar-Modified Nucleosides Using the Iodine/Triethylsilane System as N -Glycosidation PromoterArticle Published on 2024-08-202024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] anomerization apricitabine glycosyl iodide iodine/triethylsilane N-glycosidation nucleosides stereoselectivity [DOI] 10.3390/ijms25169030 PMC 바로가기 [Article Type] Article
Synthesis of Fluorinated Nucleosides/Nucleotides and Their Antiviral PropertiesReview Published on 2024-05-192024-09-05 Journal: Molecules [Category] update2024, [키워드] Antiviral carbocyclic ring clinical development clinical trials fluorinated sugar fluoro-nucleosides/nucleotides nucleosides nucleotides ribose sugar [DOI] 10.3390/molecules29102390 PMC 바로가기 [Article Type] Review
Nitrogen-Centered Radicals Derived from AzidonucleosidesReview Published on 2024-05-142024-09-05 Journal: Molecules [Category] update2024, [키워드] aminyl radicals azides iminyl radicals nitrogen-centered radicals nucleosides purines pyrimidines Radiation radiosensitizers ribonucleotide reductases [DOI] 10.3390/molecules29102310 PMC 바로가기 [Article Type] Review
Integrative Molecular Structure Elucidation and Construction of an Extended Metabolic Pathway Associated with an Ancient Innate Immune Response in COVID-19 Patientsarticle Published on 2024-02-042024-09-05 Journal: Journal of Proteome Research [Category] update2024, [키워드] antivirals Biomarkers COVID-19 deoxydidehydronucleosides extended viperin pathway NMR spectroscopy nucleosides polypharmacy RSAD2 SARS-CoV-2 Urine viperin [DOI] 10.1021/acs.jproteome.3c00654 PMC 바로가기 [Article Type] article
Synthesis and biological evaluation of new β-D-N4-hydroxycytidine analogs against SARS-CoV-2, influenza viruses and DENV-2SARS-CoV-2, 인플루엔자 바이러스 및 DENV-2에 대한 새로운 β-D-N4-하이드록시시티딘 유사체의 합성 및 생물학적 평가Article Published on 2023-03-012023-06-23 Journal: Bioorganic & medicinal chemistry letters [Category] 신종인플루엔자, [키워드] DENV-2 influenza viruses nucleosides RNA-Polymerase SARS-CoV-2 β-D-N(4)-Hydroxycytidine β-D-N(4)-O-Isobutyrylcytidine. [DOI] 10.1016/j.bmcl.2023.129174 PMC 바로가기
t6A and ms2t6A Modified Nucleosides in Serum and Urine as Strong Candidate Biomarkers of COVID-19 Infection and SeverityArticle Published on 2022-09-032022-11-15 Journal: Biomolecules [Category] SARS, 바이오마커, 변종, [키워드] addition Alter Biomarker candidate cellular RNA changes in COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients elevated Extracellular Infection LC-MS modified nucleosides. nucleoside nucleosides RNA SARS-CoV-2 searched serum severity Strong symptom severity Urine variants [DOI] 10.3390/biom12091233 PMC 바로가기
Purification and mass spectrometry study of Maillard reaction impurities in five acyclic nucleoside antiviral drugsResearch article Published on 2022-04-012022-10-05 Journal: Journal of pharmaceutical and biomedical analysis [Category] 치료제, [키워드] Acyclic nucleoside antiviral drugs analyzed antiviral drug antiviral drugs API compatibility Compound condition decrease Degradation drugs FIVE Impurities increase in ingredient Maillard reaction mass spectrometry mechanism Neutral NMR spectroscopy nucleoside nucleosides purified stability Structural identification was performed [DOI] 10.1016/j.jpba.2022.114637 [Article Type] Research article
Enhancing the Antiviral Potency of Nucleobases for Potential Broad-Spectrum Antiviral TherapiesArticle Published on 2021-12-142022-10-28 Journal: Viruses [Category] COVID-19, [키워드] Analysis antimetabolite Antiviral antiviral therapy blunting broad-spectrum cellular clearance clinical trial Combination competing coronavirus Defense Ebola virus effective emerging viruses Enhancing Favipiravir forms Frequency HCoV-OC43 Illness severity infections influenza A inhibitor Mutation NTP nucleobase nucleosides nucleotide orthomyxovirus Patient potency Potential purine reduced reducing reduction Replication riboside RNA virus SARS-CoV-2 small molecule Spread synergistic synergy Treatment Vaccine virus Zika [DOI] 10.3390/v13122508 PMC 바로가기 [Article Type] Article
Structure-Function Characteristics of SARS-CoV-2 Proteases and Their Potential Inhibitors from Microbial SourcesReview Published on 2021-11-302022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] 3-chymotrypsin-like protease 3CLpro Antiviral Bacteria candidate caused Community Compound coronavirus 2 COVID-19 COVID-19 pandemic cysteine protease drug drug design drug target expand function fungi Health HIV protease inhibitor Host Infection information inhibitor inhibitors less microbial Modification nucleic acids nucleosides nucleotides Papain-like protease platform PLPro Potential protease Proteases Protein protein synthesis reported researcher resource respiratory RNA SARS-CoV-2 SARS-CoV-2 protease SARS-CoV-2 proteases SARS-CoV-2 viral SARS-CoV2 Source Spread structures suggested the SARS-CoV-2 Transcription translation Treatment urgency virus virus replication while with COVID-19 [DOI] 10.3390/microorganisms9122481 PMC 바로가기 [Article Type] Review
Optimization of non-coding regions for a non-modified mRNA COVID-19 vaccine비변형 mRNA COVID-19 백신의 비암호화 영역 최적화Comparative Study Published on 2021-11-182022-09-10 Journal: Nature [Category] MERS, SARS, 변종, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 antigen expression binding binding and neutralizing antibodies BNT162b2 Cell Coronavirus-2 correlated COVID-19 vaccine CureVac CVnCoV cynomolgus macaque delta variant demonstrated dose effective Efficacy evaluated head Head-to-head comparison Human immunized immunogenic immunogenicity IMPROVE macaques memory B memory B cell mRNA mRNA vaccine Neutralizing antibodies Neutralizing antibody response neutralizing antibody responses neutralizing antibody titre non-coding region non-coding regions non-human primates nucleoside nucleosides optimization Pfizer Protective provided respiratory respiratory tracts response RNA vaccines robust SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variants Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 T cell T cell response T cell responses tested These data titre Trial upper and lower respiratory tracts Vaccine Viral Viral load [DOI] 10.1038/s41586-021-04231-6 PMC 바로가기 [Article Type] Comparative Study