Study of the Molecular Dynamics Stability in the Inhibitory Interaction of Tenofovir Disoproxil Fumarate against CTLA-4 in Chronic Hepatitis B PatientsOriginal Paper Published on 2023-01-012024-09-05 Journal: Medical Archives [Category] update2024, [키워드] CTLA-4 hepatitis B molecular docking nucleotide analogue tenofovir disoproxil fumarate [DOI] 10.5455/medarh.2023.77.227-230 PMC 바로가기 [Article Type] Original Paper
Identifying Structural Features of Nucleotide Analogues to Overcome SARS-CoV-2 Exonuclease ActivitySARS-CoV-2 엑소뉴클레아제 활성을 극복하기 위한 뉴클레오티드 유사체의 구조적 특징 확인Article Published on 2022-06-282022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] activity analogue animal models antivirals candidate Cell culture Combination conserved Coronaviruses COVID-19 therapeutics Critical develop drugs drugs targeting effective Effectiveness evaluate evaluated excision ExoN exonuclease feature group identifying in vitro result inhibit SARS-CoV-2 inhibitor inhibitors new SARS-CoV-2 nucleotide nucleotide analogue nucleotide analogues nucleotides offer Proofreading RdRP RdRp inhibitor reported RNA RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 variants selected sequence Spread the SARS-CoV-2 variants variety [DOI] 10.3390/v14071413 PMC 바로가기 [Article Type] Article
2′- and 3′-Ribose Modifications of Nucleotide Analogues Establish the Structural Basis to Inhibit the Viral Replication of SARS-CoV-2뉴클레오티드 유사체의 2'- 및 3'-리보스 변형은 SARS-CoV-2의 바이러스 복제를 억제하는 구조적 기초를 확립합니다Article Published on 2022-05-122022-09-11 Journal: The journal of physical chemistry letters [Category] COVID19(2023년), SARS, 치료제, [키워드] active site adenosine Affect analogue Antiviral Basis evaluated extension inhibition Modification molecular molecular dynamics nucleotide nucleotide analogue nucleotide analogues Protein provide RdRP Remdesivir ribose RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp shown stability Structural analysis Treatment [DOI] 10.1021/acs.jpclett.2c00087 PMC 바로가기 [Article Type] Article
New concepts regarding finite oral antiviral therapy for HBeAg-negative chronic hepatitis BComment Published on 2021-12-012023-06-13 Journal: Journal of hepatology [Category] B형 간염, [키워드] functional cure hepatitis B nucleoside analogue nucleotide analogue treatment discontinuation [DOI] 10.1016/j.jhep.2021.06.020 [Article Type] Comment
First-line oral antiviral therapies showed similar efficacies in suppression of serum HBcrAg in chronic hepatitis B patientsResearch Article Published on 2021-03-172023-05-22 Journal: BMC Gastroenterology [Category] B형 간염, Fulltext, [키워드] entecavir hepatitis B Hepatitis B core-related antigen nucleotide analogue tenofovir [DOI] 10.1186/s12876-021-01711-x PMC 바로가기 [Article Type] Research Article
Drug Discovery of Nucleos(t)ide Antiviral Agents: Dedicated to Prof. Dr. Erik De Clercq on Occasion of His 80th BirthdayReview Published on 2021-02-092024-09-02 Journal: Molecules [Category] 대상포진, [키워드] antiviral therapy HBV HCMV HCV HIV HSV nucleoside analogue nucleotide analogue VZV [DOI] 10.3390/molecules26040923 PMC 바로가기 [Article Type] Review
Nucleotide analogues as inhibitors of SARS-CoV PolymeraseArticle Published on 2020-12-012023-07-13 Journal: Pharmacology Research & Perspectives [Category] SARS, [키워드] COVID-19 nucleotide analogue RNA-dependent RNA polymerase SARS-CoV SARS-CoV-2 [DOI] 10.1002/prp2.674 PMC 바로가기
Similar risk of hepatocellular carcinoma during long-term entecavir or tenofovir therapy in Caucasian patients with chronic hepatitis BArticle Published on 2020-11-012023-06-13 Journal: Journal of hepatology [Category] B형 간염, [키워드] cirrhosis Liver cancer liver stiffness nucleoside analogue nucleotide analogue Treatment [DOI] 10.1016/j.jhep.2020.06.011
SARS-CoV-2 Treatment Approaches: Numerous Options, No Certainty for a Versatile VirusPharmacology Published on 2020-08-262022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE2 receptor acting administration angiotensin-converting enzyme 2 receptors Antibiotics Antimalarial drugs Antiretrovirals antiviral activity approach certainty Clinical features convalescent plasma coronavirus coronavirus disease corticoids COVID-19 current therapy drug effective Endocytic pathway endocytosis Epitopes host-virus interaction Hydroxychloroquine identify immune immune response immune system disorders immunosuppressive drug Inflammatory cytokines initial interferons kinase inhibitors Mesenchymal stem cells monoclonal antibodies monoclonal antibody neutralization nucleotide analogue Numerous pandemic pathogenic mechanism pathogenic mechanisms promote Remdesivir RNA-dependent RNA polymerase Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 vaccine Side effect similarity Spread stem cells Still therapeutic option therapeutic targets therapy Treatment Trial triggered Vaccine virus [DOI] 10.3389/fphar.2020.01224 PMC 바로가기 [Article Type] Pharmacology
Investigation of Some Antiviral N -Heterocycles as COVID 19 Drug: Molecular Docking and DFT CalculationsArticle Published on 2020-05-302022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] 6LU7 Affect Amino acid amodiaquine approved atomic binding affinity binding energy Bioactivity calculation caused comparable computation computational modeling coronavirus COVID 19 COVID-19 Critical DFT calculations docked docking drug drug target drugs effective electrostatic evaluate evaluated functional Health highest Hydrogen bond hydrophobic interaction Hydroxychloroquine inhibitor investigated investigation M pro Medicines molecular molecular docking N-heterocycles Novel coronavirus nucleotide analogue pandemic parameter parameters performed polyprotein predicted protease Protein reactivity receptor Remdesivir residue SARS-CoV-2 SARS-CoV-2 main protease selected significantly Simulation study the binding affinity translated Viral RNA were used [DOI] 10.3390/ijms21113922 PMC 바로가기 [Article Type] Article