Impaired innate antiviral defenses in COVID-19: Causes, consequences and therapeutic opportunities
Review
[키워드] ACE-2, Angiotensin-converting enzyme 2
Antiviral innate immunity
ARDS, acute respiratory distress syndrome
CoV, coronavirus
COVID-19
COVID-19, Coronavirus disease 2019
CRS, Cytokine release syndrome
IFN, interferon
IL, interleukin
interferons
IRF, Interferon regulatory factor
ISG, Interferon-stimulated gene
JAK, Janus kinase
KPNA2, karyopherin α2
LY6E, lymphocyte antigen 6 complex, locus E
MAVS, mitochondrial antiviral-signaling protein
MDA5, melanoma-differentiated gene 5
MERS, Middle East respiratory syndrome
N/L, neutrophil to lymphocyte
NF-κB, nuclear factorκB
NSP, non-structural protein
OAS, Oligoadenylate synthetase
ORF, open reading frame
pDC, Plasmacytoid dendritic cell
PRR, pattern-recognition receptor
RIG, retinoic acid-inducible gene 1
RLR, RIG-I like receptor
S, spike
SARS-CoV-2
SARS, Severe acute respiratory syndrome
STAT, Signal transducer and activator of transcription
TBK1, TANK binding kinase 1
TLR, Toll-like receptor
TMPRSS2, Transmembrane serine protease 2
TNF-α, tumor necrosis factor alpha
[DOI] 10.1016/j.smim.2021.101522 PMC 바로가기 [Article Type] Review
[DOI] 10.1016/j.smim.2021.101522 PMC 바로가기 [Article Type] Review