Evidence of SARS-CoV-2 in nasal brushings and olfactory mucosa biopsies of COVID-19 patientsCOVID-19 환자의 비강 칫솔질 및 후각 점막 생검에서 SARS-CoV-2의 증거Article Published on 2022-04-122022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] affected Analysis basal cells biopsy Cell cells Control COVID-19 COVID-19 patient cytoplasm detect distribution evidence of immunocytochemistry immunofluorescence mucosa nasal neurons Non-invasive olfactory olfactory neuroepithelium olfactory neuron Patient positive SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 positive cell SARS-CoV-2 positive cells SARS-CoV-2 positivity SARS-CoV-2 viral particle SARS-CoV-2 viral particles sustentacular cells Ultrastructural analysis Viral [DOI] 10.1371/journal.pone.0266740 PMC 바로가기 [Article Type] Article
Potential pharmacologic treatments for COVID-19 smell and taste loss: A comprehensive reviewReview article Published on 2021-12-012022-10-05 Journal: European journal of pharmacology [Category] SARS, 임상, 치료법, [키워드] ACE-2 receptor Affect Ageusia Anosmia Anti-inflammatory benefit Cell clinical trial Corticosteroid COVID-19 COVID-19 patient depolarizing Evidence expressed Gustatory hallmark information inhibitors insulin Interaction Invasion local inflammation loss of taste management mechanisms Novel coronavirus olfactory olfactory neuron pathologic pathophysiology pathway patients pharmacologic treatment Potential Potential treatment provided searched Symptom Therapeutics Treatment virus [DOI] 10.1016/j.ejphar.2021.174582 [Article Type] Review article
Severe Acute Respiratory Syndrome Coronavirus 2 Infects and Damages the Mature and Immature Olfactory Sensory Neurons of Hamsters중증 급성 호흡기 증후군 코로나바이러스 2는 햄스터의 성숙하고 미성숙한 후각 감각 뉴런을 감염시키고 손상시킵니다Article Published on 2021-07-152022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료기술, [키워드] Acute inflammation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition affecting Antigen Apoptosis Cell cells chemokine ciliated contribute coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 patient Cytokines damage destruction develop epithelial cells hamster hamsters highest immature Infection Inflammatory inflammatory cell inflammatory cell infiltration Inflammatory cytokine Inflammatory cytokines intranasal Invasion investigated less location Loss of Smell marker nasal nasal turbinate Neuron neuronal function olfactory olfactory bulb olfactory bulbs olfactory dysfunction Olfactory epithelium olfactory neuron olfactory neuron. Pathogenesis patients peaked Postinfection proinflammatory Proinflammatory cytokine proportion Protein reported respiratory respiratory epithelial cells respiratory tract infection response resulting SARS-CoV-2 SARS-CoV-2 viral Sensory sensory neuron severe acute respiratory syndrome Coronavirus Symptom tissues unique Viral load β-tubulin [DOI] 10.1093/cid/ciaa995 PMC 바로가기 [Article Type] Article
The olfactory nerve is not a likely route to brain infection in COVID-19: a critical review of data from humans and animal modelsReview Published on 2021-04-262022-10-27 Journal: Acta Neuropathologica [Category] [키워드] alternative route animal model assumed Brain Brain infection brains COVID-19 COVID-19 patient Critical Evidence expressed expression Human infect Infection lack Loss of Smell mechanism mouse model Multiple Neuro-invasion neurons New coronavirus olfactory olfactory neuron olfactory receptor neurons olfactory route Olfactory system progression Protein recent reported SARS-CoV-2 symptoms of COVID-19 the SARS-CoV-2 virus virus virus entry [DOI] 10.1007/s00401-021-02314-2 PMC 바로가기 [Article Type] Review
The olfactory nerve is not a likely route to brain infection in COVID-19: a critical review of data from humans and animal modelsReview Published on 2021-04-262022-10-27 Journal: Acta Neuropathologica [Category] COVID-19, MERS, SARS, [키워드] alternative route animal model assumed Brain Brain infection brains COVID-19 COVID-19 patient Critical Evidence expressed expression Human infect Infection lack Loss of Smell mechanism mouse model Multiple Neuro-invasion neurons New coronavirus olfactory olfactory neuron olfactory receptor neurons olfactory route Olfactory system progression Protein recent reported SARS-CoV-2 symptoms of COVID-19 the SARS-CoV-2 virus virus virus entry [DOI] 10.1007/s00401-021-02314-2 PMC 바로가기 [Article Type] Review