Stabilization of G-Quadruplex Structures of the SARS-CoV-2 Genome by TMPyP4, BRACO19, and PhenDC3Article Published on 2024-02-202024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] BRACO19 FAM-TAMRA pair FRET G-quadruplex oligonucleotide PhenDC3 RNA SARS-CoV-2 Spectroscopy TMPyP4 [DOI] 10.3390/ijms25052482 PMC 바로가기 [Article Type] Article
Surface plasmon resonance-based oligonucleotide biosensor for Salmonella Typhi detectionarticle Published on 2023-09-302024-09-01 Journal: Analytical Biochemistry [Category] 살모넬라증, [키워드] biosensor oligonucleotide Salmonella Typhi SPR surface plasmon resonance [Article Type] article
A computational approach to biological pathogenicityArticle Published on 2022-11-012022-11-15 Journal: Molecular genetics and genomics : MGG [Category] 바이오마커, [키워드] Accuracy adverse impact approach assessment Biochemistry Biomarkers clinical trial COVID-19 death Digital Digital genomic signature DNA DNA sequence energy event feature genomic Gibbs energy h-distance. Health Host humans hybridization machine machine learning machine learning model methodology microbe mitigate new strain oligonucleotide Other pandemic pathogen pathogenic Pathogenic relationship pathogenicity Pathogens/nonpathogens Perspective predict Quality reducing sensitivity Sensitivity and specificity Sickness specificity structural property [DOI] 10.1007/s00438-022-01951-w PMC 바로가기
Identification of a guanine-specific pocket in the protein N of SARS-CoV-2SARS-CoV-2의 단백질 N에서 구아닌 특이적 포켓 식별Article Published on 2022-07-162022-09-11 Journal: Communications Biology [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] addition binding biochemical C-terminal domain complex conformation conserved Coronaviruses crystal structure CTD EMSA facilitate GTP guanine identification inhibitors Interaction mutant N protein nucleotide oligonucleotide Packaging sequence Protein Region residue responsible RNA SARS-CoV-2 SARS-CoV-2 nucleocapsid sequence specificity the N protein Tryptophan [DOI] 10.1038/s42003-022-03647-8 PMC 바로가기 [Article Type] Article
Comparative genomic analysis of the human genome and six bat genomes using unsupervised machine learning: Mb-level CpG and TFBS islands비지도 머신 러닝을 사용한 인간 게놈과 6개의 박쥐 게놈 비교 게놈 분석: Mb 수준 CpG 및 TFBS 섬Comparative Study Published on 2022-07-082022-09-11 Journal: BMC Genomics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] 3D structure 3D Structures addition Algorithm Analysis artificial artificial intelligence bat bats binding Centromeric heterochromatin characteristic Characteristics chromosomes class Clustering Comparative conducted contributing to CpG diagnostic dinucleotide disease-causing distribution Ebola Emerging infectious disease feature Features function Gene Expression Genome genomes genomic Genomic analysis help hosts Human Human genome humans Infectious disease information Interaction involved knowledge machine machine learning motif natural reservoir nuclear oligonucleotide Oligonucleotide composition oligonucleotides Protein Region regions Regulation reveal RNA viruses SARS-CoV-2 self-organization Self-organizing map Self-organizing map. sequence TFS the SARS-CoV-2 thought transcription factor transcription factors variety virus viruses zoonotic [DOI] 10.1186/s12864-022-08664-9 PMC 바로가기 [Article Type] Comparative Study
Characterization of SARS-CoV-2 replication complex elongation and proofreading activitySARS-CoV-2 복제 복합체 신장 및 교정 활성의 특성화Article Published on 2022-06-102022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral base pairs biochemical characterization complex coronavirus Critical dATP degrade drug elongation exonuclease experiment feature genomic sequence groups highlight incorporation inefficient inhibitor Mutation nsp10 nsp14 nucleotide nucleotides oligonucleotide promote Proofreading RdRP reduced Replication resulting ribose RNA RNA-dependent RNA polymerase RNA-dependent RNA polymerases SARS-CoV-2 SARS-CoV-2 RdRp SARS-CoV-2 replication sequence shown target the SARS-CoV-2 Viral protein [DOI] 10.1038/s41598-022-13380-1 PMC 바로가기 [Article Type] Article
In-Silico Selection of Aptamer Targeting SARS-CoV-2 Spike ProteinSARS-CoV-2 스파이크 단백질을 표적으로 하는 앱타머의 인-실리코 선택Article Published on 2022-05-222022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification antibody Antigen antigens applied aptamer aptamer–protein interaction binding affinity coronavirus COVID-19 diagnose diagnostic diagnostic testing DNA DNA aptamer docking result domain hydrogen Hydrogen bond hydrogen bonds infected case infected cases Infectious disease Interaction MD simulation molecular molecular docking molecular dynamics Molecular dynamics simulation mutants mutated oligonucleotide quantification quartz Receptor-binding domain RNA S protein SARS-CoV-2 SARS-CoV-2 spike protein selected Selection sequence severe acute respiratory syndrome Coronavirus similarity single-stranded spike Spike protein stable complex targeting the RBD the S protein Viral detection virus was selected [DOI] 10.3390/ijms23105810 PMC 바로가기 [Article Type] Article
Enhanced Detection of Viral RNA Species Using FokI-Assisted Digestion of DNA Duplexes and DNA/RNA HybridsDNA 이중체 및 DNA/RNA 하이브리드의 FokI 지원 소화를 사용한 바이러스 RNA 종의 향상된 검출Article Published on 2022-05-102022-09-11 Journal: Analytical Chemistry [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, 치료제, [키워드] addition amplification amplified approaches battery Chain Reaction cleavage Combination complex Critical decrease detection Diagnosis digestion DNA enhanced enzyme fluorescent FokI highlighting human diseases hybrid increase isothermal limit of detection mechanism molecular nucleic acid nucleic acids oligonucleotide oligonucleotides pathogen Pathogens polymerase chain polymerase chain reaction probe proof proof of concept reduced Region reverse transcription RNA RNA molecule RNA molecules Rolling circle amplification SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variants Sensitivity and specificity Specy ssDNA the SARS-CoV-2 genome viral RNAs [DOI] 10.1021/acs.analchem.2c00407 PMC 바로가기 [Article Type] Article
Intranasal Delivery of Thermostable Subunit Vaccine for Cross-Reactive Mucosal and Systemic Antibody Responses Against SARS-CoV-2SARS-CoV-2에 대한 교차 반응성 점막 및 전신 항체 반응을 위한 열안정성 소단위 백신의 비강내 전달Article Published on 2022-05-032022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 addition Against Alpha angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-RBD Anti-RBD antibody antibody Antibody Response Antibody responses Antibody titer Antibody titers approved Beta binding binding domain Breakthrough infection breakthrough infections chitosan circulation COVID-19 COVID-19 vaccines CpG cross-reactive delivery Delta variants domain Efficacy effort enzyme exclusion FIVE genetic material help Hesitancy IgA antibodies IgG1 IgG2a IL-12 Immunity immunization IMPROVE induce inhibited interleukin interleukin-12 intranasal intranasal vaccination intranasally isotype Laboratory mice mucosal mucosal immunity mutant oligonucleotide polypeptide Prevent PROTECT RBD RBD-specific antibodies RBD-specific antibody receptor Receptor binding domain receptor binding domain (RBD) reduce respiratory respiratory viruses response responses room temperature SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants specific antibodies stability subcutaneous vaccination subunit Subunit vaccine systemic temperature the vaccine thermostable upper respiratory tract vaccination Vaccine Vaccine development Vaccine hesitancy vaccine platform variants virus [DOI] 10.3389/fimmu.2022.858904 PMC 바로가기 [Article Type] Article
CASCADE: Naked eye-detection of SARS-CoV-2 using Cas13a and gold nanoparticlesCASCADE: Cas13a와 금 나노입자를 이용한 SARS-CoV-2 육안 탐지Article Published on 2022-05-012022-09-11 Journal: Analytica chimica acta [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] acid activate aggregation approach approaches cascade cleave clinical sample clinical samples Concentration COVID-19 pandemic CRISPR CRISPR/Cas13 detect Diagnosis diagnostics Diseases effort gold Gold nanoparticle Gold nanoparticles Infectious diseases isothermal isothermal amplification molecular Naked-eye nanomaterials NASBA nasopharyngeal swabs nucleic acid nucleic acid amplification nucleic acids oligonucleotide Pathogens point-of-care Prevent Protein RNA RNase RPA SARS-CoV-2 SARS-CoV-2 RNA Scientific community sensitivity Spread ssRNA variety Viral viral nucleic acids Viral RNA [DOI] 10.1016/j.aca.2022.339749 PMC 바로가기 [Article Type] Article