An alternative approach-combination of lockdown and open in fighting COVID-19 pandemicsArticle Published on 2022-11-012022-11-16 Journal: Environmental science and pollution research inter [Category] COVID19(2023년), SARS, 변종, [키워드] approach Combination country COVID-19 COVID-19 pandemic dominant Effect high-risk population lockdown omicron Omicron variant open organized pandemic Pandemics with COVID-19 [DOI] 10.1007/s11356-022-23438-2 PMC 바로가기
Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies?COVID-19의 장기 발현: 부검을 통해 지금까지 (뿐만 아니라) 무엇을 배웠습니까?Review Published on 2022-08-012022-09-11 Journal: Virchows Archiv [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Acute kidney damage alveolar alveolar damage analytical methods Antithrombotic applicability Autopsies Autopsy cells change characterized clinical Combination conditions COVID-19 COVID-19 pandemic declining diffuse Diffuse alveolar damage direct infection disease Endothelial dysfunction explained immune response International Intussusceptive angiogenesis kidney limitation majority manifestation mechanism mechanisms morphological feature morphological features National nonspecific open organ organ injury organs pathological change pathological changes pathologist pathophysiology question recommendation Research SARS-CoV-2 supported thrombosis tissue tissue tropism tissues Treatment turn variants variants of concern vascular inflammation vasoconstriction [DOI] 10.1007/s00428-022-03319-2 PMC 바로가기 [Article Type] Review
Drug repurposing: a systematic review on root causes, barriers and facilitators약물 용도 : 근본 원인, 장벽 및 촉진자에 대한 체계적인 검토Article Published on 2022-07-292022-08-31 Journal: BMC health services research [Category] 신약개발, [키워드] Analysis approach article articles business causes Characteristics Cochrane Library Collection complex Compound consolidation core database disease drug Drug abandonment Drug development Efficacy eligible Emergency use authorization example facilitate facilitator facilitators focus food Food and Drug Administration Google Scholar Inadequate include information intellectual property knowledge lack Modification MOST open Open Science Framework outcome OVID problem PROSPERO protocol receiving Registered Registration Regulatory Repurposed drug repurposing Research Research design resource risk screened Source Support systematic review Therapies therapy Transparency treat Trial Web of Science [DOI] 10.1186/s12913-022-08272-z PMC 바로가기 [Article Type] Article
Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse originsBA.1 및 가능한 마우스 기원과 비교하여 Omicron BA.2 변이체의 증가된 감염성 및 면역 회피를 위한 구조적 및 생화학적 메커니즘Article Published on 2022-07-012022-09-11 Journal: Cell Research [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 ACE2 binding addition antibody bind binding biochemical combating dominant effective Evolution exhibit high affinity high potency human ACE2 immune evasion implication infections infective inhibit interactions mechanism neutralization activity omicron open pathway RBDs Receptor-binding domain receptor-binding domains reveal SARS-CoV-2 viral shown spike trimer Strains Structure structures therapeutic trimer variant Viral viral infections wildtype WT spike [DOI] 10.1038/s41422-022-00672-4 PMC 바로가기 [Article Type] Article
Tranilast as an Adjunctive Therapy in Hospitalized Patients with Severe COVID- 19: A Randomized Controlled Trial중증 COVID-19로 입원한 환자의 보조 요법으로서의 트라닐라스트: 무작위 대조 시험Randomized Controlled Trial Published on 2022-06-012022-09-11 Journal: Archives of medical research [Category] COVID19(2023년), SARS, 신약개발, 임상, 치료제, [키워드] 1:1 addition adjuvant therapy Admitted Patient antiviral drug antiviral drugs antiviral therapy assigned Clinical findings clinical trial collected data Combination Comparisons control group control groups Controlled COVID COVID-19 Cytokine storm death effective Efficacy ENhance evaluate expression hospital Hospitalization hospitalized patient ICU IL-1 Inflammation Inflammatory cytokine inhibitor Intervention intervention group Iran Laboratory tests LDH Long NLR NLRP3 NLRP3 inflammasome O2 Saturation open Open-label Patient patients with COVID-19 Randomly Safe SARS-CoV-2 severe COVID-19 significantly lower therapeutic effect therapeutic effects therapy TNF Tranilast Tranilast. was used with COVID-19 [DOI] 10.1016/j.arcmed.2022.03.002 PMC 바로가기 [Article Type] Randomized Controlled Trial
Ultrastable Silver Nanoparticles for Rapid Serology Detection of Anti-SARS-CoV-2 Immunoglobulins GAnti-SARS-CoV-2 면역글로불린 G의 신속한 혈청학적 검출을 위한 초안정 은 나노입자Article Published on 2022-05-242022-09-11 Journal: Analytical Chemistry [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] AgNP AgNPs anti-SARS-CoV-2 IgG AuNP calixarene classical clinical samples Degradation detection diagnostic tests Dipstick example gold IgG lateral-flow immunoassay lateral-flow immunoassays LFIA LFIAs limit of detection magnitude nanoparticle open Particles Perspective positive Rapid reported resulting SARS-CoV-2 spike protein sensitivity silver silver nanoparticle Silver nanoparticles specificity spike Spike protein stability the SARS-CoV-2 was determined was reduced [DOI] 10.1021/acs.analchem.2c00870 PMC 바로가기 [Article Type] Article
Shedding light on the toxicity of SARS-CoV-2-derived peptide in non-target COVID-19 organisms: A study involving inbred and outbred mice비표적 COVID-19 유기체에서 SARS-CoV-2 유래 펩타이드의 독성에 대한 조명: 근친교배 및 근친교배 마우스를 대상으로 한 연구Article Published on 2022-05-012022-09-11 Journal: Neurotoxicology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] acetylcholinesterase activated administration alteration animals antidepressant antioxidant anxiolytic applied biochemical Biomarker Brain C57Bl/6 J mice catalase consequence COVID-19 demonstrated depressive dismutase dispersion Effect Environmental Toxicology evaluate evaluated Evidence evidence of exposure to Field test genetic profile greater homeostasis hydrogen hydrogen peroxide Impact Laboratory locomotor maintain male mammalian mechanism memory memory deficit mice natural environments open oxidative stress Pandemic COVID-19 PCA peptide Principal component principal component analysis Protein Proteins provide reactive reduction in Research response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 particle SARS-CoV-2 particles sensitivity shedding Spike protein Superoxide Superoxide Dismutase Swiss mice. the Spike the vaccine Therapeutic strategies therapeutic strategy Toxicity Viral [DOI] 10.1016/j.neuro.2022.03.012 PMC 바로가기 [Article Type] Article
Considerations for the Feasibility of Neutralizing Antibodies as a Surrogate Endpoint for COVID-19 VaccinesCOVID-19 백신의 대리 종점으로서 중화 항체의 가능성에 대한 고려 사항Review Published on 2022-04-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 바이오마커, 변종, 진단, [키워드] Administered analyzed Antibody titers approach approved clinical trial coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine COVID-19 vaccines develop dose Effectiveness Efficacy Efficiency elicited Emergency use Endpoint endpoints Enrollment feasibility immune response immune responses National national standard neutralization neutralization test Neutralizing neutralizing antibody Neutralizing antibody response neutralizing antibody responses neutralizing antibody titers open overcome pandemic platform Prevent Research research and development Selection standard neutralization test assay surrogate surrogate endpoints. Transmissibility vaccination Vaccine Vaccines variant variants widespread [DOI] 10.3389/fimmu.2022.814365 PMC 바로가기 [Article Type] Review
Erythro-VLPs: Anchoring SARS-CoV-2 spike proteins in erythrocyte liposomesErythro-VLPS : 적혈구 리포좀에서 SARS-COV-2 스파이크 단백질을 고정시킨다Research Article Published on 2022-03-112022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 변종, [키워드] ACE-2 acute respiratory syndrome acute respiratory syndrome coronavirus 2 Administered anchoring angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 assays average binding BLI Blood blood cell Cell coronavirus coronavirus disease COVID-19 cytoplasmic membrane defined dose-dependent Dynamics ELISA enzyme enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays facilitate fluorescent functional insertion intravenously Liposome membranes molecular dynamics novel open outer membrane pandemic Particles platform Protein protocol red blood cell respiratory S-protein SARS-CoV-2 spike SARS-CoV-2 spike protein scattering Seroconversion severe acute respiratory syndrome Coronavirus surfactant the SARS-CoV-2 therapeutic strategy Therapeutics Trial variants virus viruses was used [DOI] 10.1371/journal.pone.0263671 PMC 바로가기 [Article Type] Research Article
Cryo-EM structure of a SARS-CoV-2 omicron spike protein ectodomainSARS-CoV-2 오미크론 스파이크 단백질 엑토도메인의 Cryo-EM 구조Article Published on 2022-03-032022-09-11 Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] cell entry conformations Critical cryo-EM structure ectodomain globe immune immune evasion immune surveillance mechanism mixture Mutation Neutralizing antibodies neutralizing antibody Omicron variant open RBD RBD region Receptor binding Receptor-binding domain SARS-CoV-2 Spike protein standing up Surveillance the cell the receptor-binding domain the spike protein viral strain [DOI] 10.1038/s41467-022-28882-9 PMC 바로가기 [Article Type] Article