The role of SARS-CoV-2 accessory proteins in immune evasionReview Published on 2022-12-012023-07-10 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), [키워드] accessory proteins immune evasion ORF SARS-CoV-2 [DOI] 10.1016/j.biopha.2022.113889 PMC 바로가기 [Article Type] Review
Clinical predictors and RT-PCR profile of prolonged viral shedding in patients with SARS-CoV-2 Omicron variant in Shanghai: A retrospective observational studyArticle Published on 2022-10-242022-11-16 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome Admission Analysis clearance clinical Comorbidity Coronary heart disease coronavirus Ct values cycle threshold determinant diabetes equation evaluate Frame Generalized group hospitalized patient hypertension Infection male material median age multivariable analysis N gene nasopharyngeal nucleocapsid protein omicron ORF ORF 1ab gene Patient patients with SARS-CoV-2 positive predictor predictors prolonged SARS-CoV-2 RNA shedding. prolonged viral shedding proportion receiving remained retrospective Retrospective study RT-PCR SARS-CoV-2 SARS-CoV-2 Omicron variant SARS-CoV-2 RNA significantly single-center tested the timing vaccination Vaccinations Vaccine variant viral clearance viral RNA clearance Viral RNA shedding [DOI] 10.3389/fpubh.2022.1015811 PMC 바로가기
A novel vaccine based on SARS-CoV-2 CD4+ and CD8+ T cell conserved epitopes from variants Alpha to OmicronArticle Published on 2022-10-062022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] 100% conserved Analysis Antigen Beta caused CD4 CD4+ CD8 CD8+ T cell clade clades composed confirmed cases conserved COVID-19 cross-protective deaths Delta epitope Epitopes Epsilon Eta Gamma Genome genomes GISAID greater highly antigenic HLA binding hydrophobic IFN-γ IL-10 IL-12 IL-2 IL-6 immune response immune responses immunoinformatics in silico approaches in vivo Lambda long-lasting majority memory Metadata molecular docking Mortality Mutation non-toxic offer omicron ORF ORF1ab ORF8 proteins peptide performed promoted Protein reduced Reinfection SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variants secretion severity Strains suffered T cell epitope TGF-β Th1 the Spike the vaccine TLR4 Vaccine variant variants virus virus transmission WHO Wuhan [DOI] 10.1038/s41598-022-21207-2 PMC 바로가기
A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions액세서리 단백질이 결실된 생약독화 SARS-CoV-2 백신 후보Article Published on 2022-07-272022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] Antiviral approved biosafety cultures deleted Deletion hamster hamsters immunization interferon interferon signaling K18-hACE2 live-attenuated vaccine mNeonGreen Mouse models neutralization ORF ORF3a ORFs Phosphorylation primary human airway PROTECT Protein replicate Replication reporter Research SARS-CoV-2 SARS-CoV-2 vaccine sequence Stat1 Transmission vaccine production Vero-E6 cell Viral viral transcription virus wild-type SARS-CoV-2 wild-type virus [DOI] 10.1038/s41467-022-31930-z PMC 바로가기 [Article Type] Article
Host-Genome Similarity Characterizes the Adaption of SARS-CoV-2 to Humans숙주-게놈 유사성은 SARS-CoV-2의 인간 적응을 특징짓는다Article Published on 2022-07-122022-09-11 Journal: Biomolecules [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptability Alpha Analysis Beta coronavirus correlation dataset Delta delta variant evade evade immunity FIVE Frame Gamma Genome genomes help HGS high mutation rate highest Host host genome host genome similarity host innate immunity Human IFN-β immune system Immunity in vivo Indicator Innate immunity Interaction lowest mechanism Mutation mutation rate omicron Omicron variants Open reading frame ORF populations puzzle SARS-CoV SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus shown signaling pathway similarity strain suppression variant variants viral genomes [DOI] 10.3390/biom12070972 PMC 바로가기 [Article Type] Article
Detection and Stability of SARS-CoV-2 in Three Self-Collected Specimen Types: Flocked Midturbinate Swab (MTS) in Viral Transport Media, Foam MTS, and Saliva자체 수집한 3가지 표본 유형에서 SARS-CoV-2의 검출 및 안정성: 바이러스 수송 배지, 거품 MTS 및 타액의 무리를 이루는 중비갑개 면봉(MTS)Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ambient Analysis children cohorts collected Community Concordance conditions coronavirus COVID-19 detection evaluated exposure to facilitate feasible finding Foam illness illnesses in viral nucleocapsid Open reading frame ORF pandemic positive provided quantification reading respiratory respiratory specimens RT-PCR RT-PCR detection Saliva saliva samples saliva specimen saliva specimens sample collection SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 RNA SARS-CoV-2 testing sensitivity severe acute respiratory syndrome Coronavirus specimen specimen collection spike stability Support Swab temperature tested Transport Transport media transported viral transport media VTM widespread [DOI] 10.1128/spectrum.01033-22 PMC 바로가기 [Article Type] Article
Insertion-and-Deletion Mutations between the Genomes of SARS-CoV, SARS-CoV-2, and Bat Coronavirus RaTG13SARS-CoV, SARS-CoV-2 및 박쥐 코로나바이러스 RaTG13의 게놈 간의 삽입 및 삭제 돌연변이Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 base bases bat bat coronavirus RaTG13 Complete coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) developmental distribution FIVE Frame gene sequence Genome genome sequence Genome sequences genomes Inconclusive INDEL indels insertion insertion-and-deletion mutation mechanism MOST Mutation mutation rate mutations Noncoding region nonstructural protein 3 Open reading frame ORF ORF8 ORF8 gene ORF8 genes Point mutation point mutations protein 3 RaTG13 replaced REPLACED BY replacement S1 domain SARS-CoV SARS-CoV-2 SARS-CoV-2 genome sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus (SARS-CoV) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike protein the SARS-CoV-2 genome the spike protein viral genome virus [DOI] 10.1128/spectrum.00716-22 PMC 바로가기 [Article Type] Article
Genome sequence diversity of SARS-CoV-2 obtained from clinical samples in Uzbekistan우즈베키스탄의 임상 샘플에서 얻은 SARS-CoV-2의 게놈 서열 다양성Article Published on 2022-06-272022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Alpha Amino acid amino acid substitution annotation association change clade clades clinical isolates clinical sample Cluster coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity D614G Deleterious Deletion Delta Denmark disease severity evidenced Evolution female followed by genetic diversity Genome Genomic analysis genomic change Genotype help Identified isolate isolates male Missense Missense mutation Missense mutations Mutation Nextstrain NSP Nsp12 nsp13 Nsp3 nsp4 NSP6 nucleotide Open reading frame ORF ORF7a Pathogenesis PCR-positive patient Protein reading regions Research Russia SARS-CoV SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants sequence severe acute respiratory syndrome Coronavirus severity significantly SNP SNPs subclade Substitution synonymous Tashkent the Spike two group two groups USA variant variants Variation WGS whole genome sequence with COVID-19 [DOI] 10.1371/journal.pone.0270314 PMC 바로가기 [Article Type] Article
Detection of SARS-CoV-2 intra-host recombination during superinfection with Alpha and Epsilon variants in New York City뉴욕시에서 알파 및 엡실론 변이체로 중복 감염 중 SARS-CoV-2 숙주 내 재조합 검출Article Published on 2022-06-252022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, 치료법, 치료제, [키워드] allele Alpha Alpha variant B.1.1.7 B.1.429 classic coding regions Coronavirus replication detection Diversity Epsilon feasible full genome sequencing functions generate genetic diversity Genome genome sequence genomes Haplotype Host identify independent individual infect New York City nucleocapsid Occurrence ORF pathogen Pathogens Recombination reveal S gene SARS-CoV-2 superinfection Support variant virus [DOI] 10.1038/s41467-022-31247-x PMC 바로가기 [Article Type] Article
Performance of the TaqMan COVID-19 Pooling Kit for detection of SARS-CoV-2 in asymptomatic and symptomatic populations무증상 및 유증상 집단에서 SARS-CoV-2 검출을 위한 TaqMan COVID-19 풀링 키트의 성능Article Published on 2022-06-102022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Algorithm analytical sensitivity applicability Asymptomatic Asymptomatic case Asymptomatic cases Asymptomatic COVID-19 Chain Reaction China clinical clinical evidence Cohort cohorts coronavirus coronavirus disease COVID-19 curated demonstrated detect effective Evidence expected FIVE Frame gold gold standard higher education independent t-test labor lack nare nucleocapsid Open reading frame ORF ORF1ab P-value p-values pandemic PCR testing performance performed polymerase chain polymerase chain reaction pool pooling Population positive sample Prevalence Qualitative reported resource reverse transcriptase RNA RT-PCR RT-qPCR SARS-CoV-2 severe acute respiratory syndrome Coronavirus strain supported surveillance testing Swab symptomatic symptomatic and asymptomatic t-test TaqMan transcriptase Volume Wuhan [DOI] 10.1371/journal.pone.0269798 PMC 바로가기 [Article Type] Article