NSP4 and ORF9b of SARS-CoV-2 Induce Pro-Inflammatory Mitochondrial DNA Release in Inner Membrane-Derived Vesicles
Article
[키워드] airway epithelial cells
anti-apoptotic
approach
BCl2
BCL2 antagonist/killer
caused
cell death
cell-free mitochondrial DNA
changes
co-culture
co-cultured
COVID-19
COVID-19 patient
Effect
Effects
epithelial cells
functional
induce
inhibit
Inner
Interaction
intercellular
intercellular mitochondrial transfer
knockdown
MCL1
mechanism
membrane vesicle
mitigate
mitochondrial
mitochondrial DNA
Mortality
MSC
MSCs
myeloid cell
myeloid cell leukemia-1
nsp4
Orf9b
outer membrane
overexpression
plasma
pro-apoptotic
pro-inflammatory
Protein
Release
reversed
SARS-CoV-2
SARS-CoV-2 protein
screened
significantly
stem cell
therapeutic
Therapeutic approach
these cell
transfer
Treatment
tunneling nanotubes.
[DOI] 10.3390/cells11192969 PMC 바로가기
[DOI] 10.3390/cells11192969 PMC 바로가기