A reduced proteomic signature in critically ill Covid-19 patients determined with plasma antibody micro-array and machine learningResearch Published on 2024-05-172024-09-05 Journal: Clinical Proteomics [Category] update2024, [키워드] COVID-19 machine learning organ system Sepsis targeted proteomics [DOI] 10.1186/s12014-024-09488-3 PMC 바로가기 [Article Type] Research
Organ and cell-specific biomarkers of Long-COVID identified with targeted proteomics and machine learningarticle Published on 2023-02-212024-09-05 Journal: Molecular Medicine [Category] update2024, [키워드] Biomarker cell types COVID-19 long-COVID machine learning organ system targeted proteomics [DOI] 10.1186/s10020-023-00610-z PMC 바로가기 [Article Type] article
Plant formulation ATRICOV 452 in improving the level of COVID-19 specific inflammatory markers in patientsResearch article Published on 2022-08-012022-10-05 Journal: Contemporary Clinical Trials Communications [Category] 바이오마커, 신약개발, 임상, [키워드] adverse event assigned Care clinical trial conducted COVID-19 COVID-19 patient CTRI determine dose dropped effective Efficacy evaluate faster Frequency healthcare healthy healthy volunteer hospital Human Importance IMPROVE Inflammatory marker inflammatory markers objective organ system oxygen Patient phase Phase 1 Phase 2 phase 2 trial Placebo plant Plant formulation (ATRICOV 452) primary analysis population randomization receive reduce Registration Result Safe setting Standard of care Support therapeutic intervention Tolerability treatment group Trial Volunteer [DOI] 10.1016/j.conctc.2022.100961 [Article Type] Research article
High viral loads: what drives fatal cases of COVID-19 in vaccinees? – an autopsy study높은 바이러스 부하: 백신 접종자의 치명적인 COVID-19 사례를 유발하는 요인은 무엇입니까? - 부검 연구Article Published on 2022-08-012022-09-11 Journal: Modern pathology : an official journal of the Unit [Category] COVID19(2023년), SARS, 바이오마커, 변종, 임상, 진단, 치료기술, 치료법, [키워드] accompanied analyzed Antibody-dependent enhancement Autopsies autopsy study Bacterial case study cause causes collected Comorbidities Comorbidity COVID-19 Ct-value Ct-values death Deceased determine died dissemination Factors histological immune system Immunoglobulin immunosuppressive immunosuppressive conditions individual Lungs malignancies Most patient Most patients Occurrence organ organ system organ systems Patient performed real-time RT-PCR RT-PCR RT-qPCR SARS-COV-2 infection SARS-CoV-2 infections significantly increased suffered upper airway upper airways vaccinated individuals vaccination Vaccine vaccinee vaccinees Viral viral loads viral spread Viral variants virus [DOI] 10.1038/s41379-022-01069-9 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamstersArticle Published on 2022-05-092022-10-04 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 치료기술, 치료법, [키워드] acute respiratory syndrome amplified benefit cascade cause circulating pro-inflammatory cytokine Complication complications of COVID-19 coronavirus COVID-19 COVID-19 patients COVID19 Cytokine dysregulation Effect evaluated Extrapulmonary hamster hamsters increasingly induce Infection Inflammatory inflammatory disease information less Long-term follow-up metabolism organ system pathogenesis of SARS-CoV-2 Patient pro-inflammatory Prophylactic respiratory tract SARS-CoV-2 SARS-COV-2 infection skeletal therapeutic intervention tissue tissues vertebrae viral infection [DOI] 10.1038/s41467-022-30195-w PMC 바로가기 [Article Type] Article
Genetic and Clinical Characteristics of Patients in the Middle East With Multisystem Inflammatory Syndrome in Children중동의 소아 다기관 염증 증후군 환자의 유전적 및 임상적 특성Multicenter Study Published on 2022-05-022022-09-11 Journal: JAMA Network Open [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI age Asian association attributes children clinical Clinical characteristics Clinical course Clinical outcome clinical outcomes cohort study complications conducted contribute Control control group controls Deleterious disease disease entity disease onset dose dysregulated Exome Fisher exact test Genetic genetic finding genetic findings Genetic variant genetic variants healthy children heterozygous variant identify IFNA6 IFNB1 IL22RA2 immune-related genes Immunoglobulin Inflammatory Inflammatory marker inflammatory markers Intravenous immunoglobulin Jordan laboratory biomarkers laboratory characteristics male manifestation Mann-Whitney U test matched control middle Middle East MIS-C multicenter cohort study neurologic organ organ system outcome participant participated Patient Population recruited reported SARS-CoV-2 SARS-COV-2 infection Sequencing significantly syndrome TLR3 TLR6 Treatment United Arab Emirate United Arab Emirates variant variants was performed was used were measured [DOI] 10.1001/jamanetworkopen.2022.14985 PMC 바로가기 [Article Type] Multicenter Study
The clinical features and estimated incidence of MIS-C in Cape Town, South Africa남아프리카 케이프타운에서 MIS-C의 임상적 특징 및 추정 발생률Article Published on 2022-05-022022-09-12 Journal: BMC Pediatrics [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] abdominal pain Affect age Analysis black calculated Cape cardiac children children with MIS-C clinical clinical feature clinical manifestation Coagulation Cohort collected comparison CRP D-dimer deaths demographic data Diagnosis eight Epidemiology ferritin Fever fibrinogen global health Haemoglobin healthy children highlight hospital Hospital stay ICU admission immune incidence independent Infection Inflammatory intravenous invasive ventilation involved lack Logistic regression Low-middle income countries marker median median age Methylprednisolone MIS-C neutrophil count organ system outcome Oxygen therapy paediatrics pandemic performed Peritoneal dialysis Rash recruited renal required SARS-CoV-2 SARS-CoV-2 antibodies serum Seven sodium South Africa Support Surveillance syndrome Tachycardia the healthy town Treatment was tested white cell [DOI] 10.1186/s12887-022-03308-z PMC 바로가기 [Article Type] Article
Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study Research Published on 2022-04-272022-10-05 Journal: Scientific Reports [Category] 유전자 메커니즘, 진단, 치료법, [키워드] 30-Day mortality affecting Analysis applied approach association clinical Clinical data clinical symptom clinically Clustering Community Confusion cough COVID-19 determine diagnostic diarrhoea disease duration of symptom Dyspnoea fatigue female Fever Gastrointestinal symptom granular hospitalised hospitalised patient identify in-hospital mortality Interpretation ISARIC Mild Mortality no symptoms observation Older organ system Patient pauci-symptomatic presentation presenting prospective cohort recruited recruitment Replication replication analysis reported robust self-reported symptom Symptom Symptoms therapeutic Unsupervised clustering utility vomiting with COVID-19 [DOI] 10.1038/s41598-022-08032-3 [Article Type] Research
Endocrine Follow-up During Post-Acute COVID-19: Practical Recommendations Based on Available Clinical EvidenceReview article Published on 2022-04-012022-10-05 Journal: Endocrine practice : official journal of the American College of [Category] 임상, [키워드] acute phase Admission Affect approach Atypical biochemical clinical Course COVID-19 database described Diabetes Mellitus dysfunction Effect Endocrine endocrine system euthyroid sick expected Follow-up function glycemic control Hypocalcemia IMPROVE intensive care literature review Male hypogonadism objective organ system Patient performed physician pituitary apoplexy Postacute COVID-19 recommendation Result screened selected serum calcium subsequent syndrome the disease thyroid dysfunction Thyroiditis widespread worsening [DOI] 10.1016/j.eprac.2022.02.003 [Article Type] Review article
Protocol summary and statistical analysis plan for I ntensive N utrition T herapy compar E d to usual care i N cri T ically ill adults (INTENT): a phase II randomised controlled trial집중 영양 치료에 대한 프로토콜 요약 및 통계 분석 계획과 일반 치료 비교 중환자(INTENT): 2상 무작위 대조 시험Article Published on 2022-03-082022-09-11 Journal: BMJ Open [Category] 임상, [키워드] adult intensive & Alfred Hospital analysed anticipated approval bloodstream Care conducted Controlled trial Critical Critical care Critically ill critically ill adult patients Critically ill patient critically ill patients Department determine dietetics disability Ethics ethics committee exclusion criteria feasible greater hospital hospital discharge Hospital stay Human Human Research Ethics Committee ICU include Inclusion infection rate Intensive intensive care intensive care unit intention-to-treat basis International Intervention media multicentre New Northern Territory nutrition nutrition & nutrition care Nutrition therapy nutritional support occur organ Organ failure organ system outcome outcomes parallel-group participant Patient peer-reviewed Primary outcome Protein randomisation randomised randomised controlled trial RCT receive recruited recruitment registration number rehabilitation rehabilitation medicine Research Ethics Result Sample size secondary Secondary outcomes social media Statistical analysis plan study period system failure therapy treat Trial usual care Ventilated Ventilation ventilator Ventilator-free days [DOI] 10.1136/bmjopen-2021-050153 PMC 바로가기 [Article Type] Article