CASA: a comprehensive database resource for the COVID-19 Alternative Splicing AtlasArticle Published on 2022-10-202022-11-15 Journal: Journal of Translational Medicine [Category] 유전자 메커니즘, 치료기술, 치료제, [키워드] affected alteration Analysis Atla cell line conditions COVID-19 database dataset Diseases drug-target interaction event events facilitate functional annotation help host cell human cell identify immune response IMPROVE Infectious disease mechanism mechanisms Organoid performed platform profile Protein protein expression provided Quantitative data regulate Regulatory Research resource RNA RNA-seq dataset severity splicing tissues transcriptional virus [DOI] 10.1186/s12967-022-03699-8 PMC 바로가기
Computational exploration of the dual role of the phytochemical fortunellin: Antiviral activities against SARS-CoV-2 and immunomodulatory abilities against the hostArticle Published on 2022-10-012022-11-15 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] activity acute respiratory syndrome analyses Analysis Antiviral antiviral activity apoptosis pathway approach bind binding site Colon coronavirus disease Coronavirus-2 COVID-19 COVID-19 patients effective endoribonuclease enrichment enrichment analysis evaluate Fortunellin generate Genetic growth Host identify immunomodulation immunomodulatory immunomodulatory capability Infection inherent inhibiting Invasion liver lung cell majority mechanism MM-GBSA analysis molecular molecular docking molecular dynamics Molecular dynamics simulation Multi-target mutability network network pharmacology NHBE Ontology Organoid pancreatic pathway per day pro-inflammatory cytokine protective immunity protein-protein interaction SARS-CoV-2 SARS-CoV-2. Support target target proteins targets the SARS-CoV-2 therapeutic tissue damage tissues treating COVID-19 viral replication virion virus [DOI] 10.1016/j.compbiomed.2022.106049 PMC 바로가기
Applications of human organoids in the personalized treatment for digestive diseasesArticle Published on 2022-09-272022-11-16 Journal: Signal Transduction and Targeted Therapy [Category] SARS, 유전자 메커니즘, [키워드] application approach build Chemotherapy Clinical treatment CRISPR-Cas9 digestive digestive system disease Diseases dose Drug screening epithelial facilitated Genetic helping highlight human physiology in vitro include Infection Intervention mechanism model system organ Organoid over pathogenic pathogenic mechanism Patient Perspective physiological Research SARS-CoV-2 targets test model therapy tissue Traditional Treatment [DOI] 10.1038/s41392-022-01194-6 PMC 바로가기
Human Nasal Organoids Model SARS-CoV-2 Upper Respiratory Infection and Recapitulate the Differential Infectivity of Emerging VariantsArticle Published on 2022-08-302022-11-16 Journal: mBio [Category] SARS, 변종, [키워드] acidic pH airway Airway organoids Cell cellular ciliary ciliary damage ciliated cell Culture Delta Efficiency generate higher infectivity Human imperative in vitro model Infection Infectivity Interaction maturation Model monolayer morphologically nasal nasal epithelial cell nasal epithelium nasal organoids nasopharyngeal omicron Organoid Primary infection protocol remained replicative fitness respiratory respiratory viruses robust SARS-CoV-2 tight junction. tight junctions Transmissibility Transmission upper upper respiratory infection upper respiratory tract variant variants viral pathogenesis virus spread [DOI] 10.1128/mbio.01944-22 PMC 바로가기
A Retinol Derivative Inhibits SARS-CoV-2 Infection by Interrupting Spike-Mediated Cellular EntryArticle Published on 2022-08-302022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome all-trans retinoic acid analogue antibody antiviral activity Apoptosis ATRA bind binding Cell cellular cellular entry Compound coronavirus Coronaviruses COVID-19 derivative disease Efficacy etiological agent feasibility global pandemic growth human cell line hydrophobic pocket include inhibitory Interaction Interrupting life-threatening coronavirus disease Lower respiratory tract mechanism metabolite organ systems Organoid pharmacological physiological prevention of COVID-19 RBD Receptor binding domain regulate reported retinol S trimer SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants Spike protein structural mechanism. the SARS-CoV-2 therapeutic trimer Vaccine vitamin A [DOI] 10.1128/mbio.01485-22 PMC 바로가기
A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination Research Published on 2022-08-222022-10-05 Journal: Nature nanotechnology [Category] SARS, 임상, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome anti-SARS-CoV-2 association binding caused cells coronavirus Delta effective eliminated enzyme exhibit facilitate Host human airway epithelial Infection inhibiting macrophages mice omicron Organoid pandemic phagocytosed promote Receptor binding domain reduce Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant selective the spike protein Therapeutic strategies therapy two-dimensional variants of concern virus virus elimination virus entry widespread wild-type SARS-CoV-2 [DOI] 10.1038/s41565-022-01177-2 [Article Type] Research
SARS-CoV-2 spike N-terminal domain modulates TMPRSS2-dependent viral entry and fusogenicitySARS-CoV-2 스파이크 N-말단 도메인은 TMPRSS2 의존성 바이러스 진입 및 융합원성을 조절합니다Article Published on 2022-08-162022-09-11 Journal: Cell Reports [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 airway B.1.617 cell-cell fusion characterized chimeric spike chimeric spikes coronavirus CP: Microbiology Delta enrichment Entry exhibit function Fusogenicity increase Infection Interaction lentivirus Lineage lung cell lung cells Microbiology modulate Mutation N-terminal domain NTD NTDs omicron Organoid organoids pseudotyped Region S1/S2 cleavage S1/S2 cleavage efficiency SARS-CoV-2 SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus spike Spike. TMPRSS2 transfer variants variants of concern viral entry virus entry VOCs wild-type [DOI] 10.1016/j.celrep.2022.111220 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection impairs the insulin/IGF signaling pathway in the lung, liver, adipose tissue, and pancreatic cells via IRF1SARS-CoV-2 감염은 IRF1을 통해 폐, 간, 지방 조직 및 췌장 세포의 인슐린/IGF 신호 전달 경로를 손상시킵니다Article Published on 2022-08-012022-09-11 Journal: Metabolism: clinical and experimental [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Activation adeno-associated virus adipose Adipose tissue AKT ameliorated analyzed association Autopsy Calu3 Calu3 cell CaLu3 cells Cell cell survival cells condition contribute COVID-19 COVID-19 pathology COVID-19 patient COVID-19 patients COVID-19 severity Critical critical patient critical patients cytokine determine Dexamethasone diabetes Diabetic diabetic patients Dihydrotestosterone Endocrine energy metabolism European population evaluate Evidence exacerbated exhibited Gain Gene Expression Genes GFP HEK293T Hospitalized Host human ACE2 human cells hyperglycemia impair impairment infected with SARS-CoV-2 insulin insulin resistance Insulin signaling Insulin/IGF signaling pathway interferon regulatory factor Interferone intron IRF1 liver lung Lungs male Male sex MAPK metabolic metabolic abnormalities Metabolic abnormality metabolism mouse model mTOR Multiorgan dysfunction Multiple organ damage Non-COVID-19 Non-COVID-19 patients obese obesity Older Older age Organoid overexpressing pancreatic Pancreatic cell pancreatic islets pathology patients patients with COVID-19 PI3K potential mechanism Prevalence provide Regulation reported Repository risk factor Risk factors SARS-CoV-2 SARS-CoV-2 infected cell SARS-CoV-2 infected cells SARS-COV-2 infection serotype severe COVID-19 severity Signaling signaling pathway significantly stem cell survival tissue tissue damage Tissue damage. tissues Transcriptome transcriptome dataset transcriptome datasets Transgenic mouse variant Whole blood whole blood transcriptome with COVID-19 [DOI] 10.1016/j.metabol.2022.155236 PMC 바로가기 [Article Type] Article
Reduced Replication Efficacy of Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant in “Mini-gut” Organoids"Mini-gut" 오르가노이드에서 중증 급성 호흡기 증후군 코로나바이러스 2 오미크론 변이체의 복제 효율 감소Article Published on 2022-08-012022-09-11 Journal: Gastroenterology [Category] COVID19(2023년), SARS, 변종, [키워드] coronavirus 2 omicron Organoid respiratory [DOI] 10.1053/j.gastro.2022.04.043 PMC 바로가기 [Article Type] Article
Using human iPSC-derived kidney organoids to decipher SARS-CoV-2 pathology on single cell level단일 세포 수준에서 SARS-CoV-2 병리를 해독하기 위해 인간 iPSC 유래 신장 오르가노이드 사용Article Published on 2022-07-192022-09-12 Journal: STAR protocols [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Cell Cell Biology cells changes in Complete kidney kidney organoid kidney organoids Microbiology organ Organoid organoids pathology protocol reveal SARS-CoV-2 Sequencing analysis Single Cell single cell level single cell suspensions Single-cell RNA sequencing STEM stem cells. Transwell virus virus infection [DOI] 10.1016/j.xpro.2022.101612 PMC 바로가기 [Article Type] Article