Mouse models of COVID-19 recapitulate inflammatory pathways rather than gene expressionArticle Published on 2022-09-262022-11-16 Journal: PLoS Pathogens [Category] SARS, 유전자 메커니즘, [키워드] ACE2 Analysis approach bioinformatics Concordance COVID-19 debatable differentially expressed gene expressed expression Gene Expression hACE2 Human immune signature Immunity immunopathology inflammatory pathway K18-hACE2 lung damage Lungs mice mouse model orthologue overlap promoter SARS-CoV-2 single copy transcriptional profile transcriptional response Treatment Viral load virus wild-type [DOI] 10.1371/journal.ppat.1010867 PMC 바로가기
Cell transcriptomic atlas of the non-human primate Macaca fascicularis Research Published on 2022-04-132022-10-05 Journal: Nature [Category] 진단, [키워드] associations Cell dataset Diseases distribution genetic disease Human humans Interaction mapped NHP NHPs non-human primate orthologue phylogenetically provide receptor reconstructed resource tissue transcriptomic utility virus Wnt [DOI] 10.1038/s41586-022-04587-3 [Article Type] Research
ACE and ACE2: insights from Drosophila and implications for COVID-19Review article Published on 2021-12-072022-10-05 Journal: Heliyon [Category] 변종, [키워드] accelerated ACE ACE2 Acer acute respiratory syndrome addition Ance Biochemistry Cardiovascular function catalytically cellular entry conserved coronavirus coronavirus disease COVID-19 COVID-19 pandemic Drosophila Drosophila melanogaster enzyme function functional highlight homologue homology identify implication in vivo knowledge mammalian organism orthologue pathogenicity peptides provide raise recent receptor renin-angiotensin system Research responsible SARS-CoV-2 therapeutic intervention unique utility Vaccine variants various coronaviruses Vasoactive Virus-host interaction [DOI] 10.1016/j.heliyon.2021.e08555 [Article Type] Review article
ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species Research Published on 2021-03-012022-10-05 Journal: Nature Ecology & Evolution [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ACE2 receptor acute respiratory syndrome Analysis angiotensin-converting enzyme 2 bat bat ACE2 both virus both viruses cell lines Contact coronavirus coronavirus disease COVID-19 Critical Cross-species transmission functional Genetic Host host receptor Human human cell humans identify Infection infection assay Interaction knowledge no correlation orthologue pandemic phylogenetically Probability receptor Receptor binding residue reveal SARS-CoV SARS-CoV-2 SARS-COV-2 infection suggested Support susceptibility Variation viral entry viral spike protein [DOI] 10.1038/s41559-021-01407-1 [Article Type] Research
Mouse Ifit1b is a cap1-RNA–binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1cImmunology Published on 2020-12-182022-10-30 Journal: The Journal of Biological Chemistry [Category] Coronavirus, [키워드] antiviral activity bind binding cells cofactor competing complex coronavirus Coronavirus infection facilitate higher eukaryotes Host host cell Human human infection IFIT1 IFIT3 Infection inhibit Innate immunity interferon-induced protein interferon-induced proteins with tetratricopeptide repeats (IFIT) Interpretation knockout lack Methylation mice Modification modulate mouse mouse model mRNA murine nucleotide orthologue plasticity Protein regulated restrict RNA RNA-binding protein rodents similarity stimulatory translation translation control viral immunology virus yielding [DOI] 10.1074/jbc.RA120.014695 PMC 바로가기 [Article Type] Immunology
SARS-CoV-2 Is Restricted by Zinc Finger Antiviral Protein despite Preadaptation to the Low-CpG Environment in HumansResearch Article Published on 2020-10-162022-10-29 Journal: mBio [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Analysis Antiviral bat bat coronaviruses cofactor Comprehensive conserved coronavirus coronavirus disease COVID-19 CpG CpG suppression defined dinucleotide effective effector Efficiency Environment evaluated Evidence Evolution experiment expressed expression expression levels finger genomic greater Host Human human coronaviruses human lung cells humans I, II IFN IFN-α IFN-γ IFNs immune in viral inhibit SARS-CoV-2 inhibited innate response interferon isoform KHNYN lowest orthologue orthologues pandemic pathogen promote Protein recent reduced restrict Restricted RNA sequences SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 RNA sequence significantly suppressed target the SARS-CoV-2 genome therapy Treatment TRIM25 Type viral pathogen ZAP Zinc zoonosis [DOI] 10.1128/mBio.01930-20 PMC 바로가기 [Article Type] Research Article
Identification of the transcription factor Miz1 as an essential regulator of diphthamide biosynthesis using a CRISPR-mediated genome-wide screenCRISPR 매개 게놈 전체 화면을 사용하여 디프타마이드 생합성의 필수 조절자로서의 전사 인자 Miz1 식별Research Article Published on 2020-10-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate Bacterial bacterial toxin bind binding site Biosynthesis Cell complex Consensus conserved CRISPR Diphthamide DPH1 Dph7 Drosophila eEF2 elegans embryonic lethal eukaryotes eukaryotic Evolution expression Factor Genes histidine human cells humans identification identify independent key factor mammals mice Modification modifications molecular target mRNA translation observation opens orthologue Pathogenesis pathway performed promoter Protein proximal question raise regulated Regulation remained required residue Seven Taking toxin toxins Transcription transcription factor transcriptional regulation unique unsaturated while yeast [DOI] 10.1371/journal.pgen.1009068 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 spike protein predicted to form complexes with host receptor protein orthologues from a broad range of mammalsArticle Published on 2020-10-052022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] ACE2 analysed bind calculated caused change changes in complex complexes Computational biology and bioinformatics contribute contributing to correlated detrimental Host host cells host range host receptor Human human ACE2 human SARS-CoV-2 strain infect Infection infection risks Interaction investigated mammal mammals management Molecular modelling Mutation orthologue phylogenetically predict predicted processed Protein receptor Receptor binding reservoir residue S-protein SARS-CoV-2 SARS-CoV-2 spike protein Surveillance TMPRSS2 transmitted Undetermined viral spike protein Virology virus with COVID-19 zoonotic origin [DOI] 10.1038/s41598-020-71936-5 PMC 바로가기 [Article Type] Article
A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures Research Published on 2020-08-272022-10-05 Journal: Nature [Category] SARS, 유전자 메커니즘, 치료기술, 치료법, 치료제, [키워드] ACE2 acute respiratory syndrome administration angiotensin-converting enzyme 2 animal model BALB/c mice caused cells Clinical use clinically coronavirus coronavirus disease COVID-19 demonstrated disease pathogenesis epithelial cell exhibited Express expression Host Human human ACE2 inefficient infect inhibit Interaction Laboratory lower airway mice mouse-adapted SARS-CoV-2 orthologue phenotype primary human airway promoter Prophylactic receptor replicate SARS-CoV-2 SARS-CoV-2 disease SARS-CoV-2 replication SARS-CoV-2 spike protein severe disease spread to Support therapeutic transgenic mice Transmission Treatment utility viral spike protein virus wild-type [DOI] 10.1038/s41586-020-2708-8 [Article Type] Research
ACE2 diversity in placental mammals reveals the evolutionary strategy of SARS-CoV-2Evolutionary Genetics Published on 2020-06-082022-10-31 Journal: Genetics and Molecular Biology [Category] COVID-19, [키워드] ACE2 ACE2 binding site Analysis catalytic domain contribute coronavirus COVID-19 Critical difference evolutionary dynamics Factors Genetic Genomic analysis hosts human populations humans identify infect infecting Infection innate immune responses inter and intra-species diversity mammal membrane protein Mortality natural selection New coronavirus orthologue pandemic of COVID-19 performed placental placental mammals polymorphism Positive selection rate of infection responsible reveal SARS-CoV-2 selected trajectory Variation virus [DOI] 10.1590/1678-4685-GMB-2020-0104 PMC 바로가기 [Article Type] Evolutionary Genetics