Ultrasensitive monitoring of SARS-CoV-2-specific antibody responses based on a digital approach reveals one week of IgG seroconversionArticle Published on 2022-12-012022-11-15 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] addition antibodies Antibody Response approach AUC collected COVID-19 COVID-19 patient diagnostic diagnostics Donor Extreme early-stage seroconversion faster flow cytometry healthy IgG IgG and IgM IgG/IgM antibodies IgM immunoassay immunoassays immunological inactivated nucleic acid nucleic acids other diseases pathogen-specific Patient peptide platform probe Protein RBD reveal Rhesus monkeys SARS-CoV-2 S2 sensitivity Seroconversion seroconversion time Simoa tested Ultrasensitive digital detection. vaccination virus wild-type [DOI] 10.1016/j.bios.2022.114710 PMC 바로가기
The failure of drug repurposing for COVID-19 as an effect of excessive hypothesis testing and weak mechanistic evidenceArticle Published on 2022-10-182022-11-16 Journal: History and philosophy of the life sciences [Category] COVID19(2023년), SARS, 신약개발, [키워드] agency Analysis applied approval clinical trial Compound conducted COVID COVID-19 EBM+ effective Efficacy Evidence example Excessive hypothesis testing explain false-positive result False-positive results favor Hydroxychloroquine Hypothesis less Mechanistic evidence Medical nihilism. Medicine ongoing trial other diseases Perspective risk second tested therapeutic therapy Treatment treatment for COVID-19 Trial [DOI] 10.1007/s40656-022-00532-9 PMC 바로가기
Immunological memory to SARS-CoV-2 infection and COVID-19 vaccinesArticle Published on 2022-09-012022-11-15 Journal: Immunological reviews [Category] COVID19(2023년), SARS, 진단, [키워드] acute infectious disease adaptive immune system adenoviral vectors anatomical antibodies antibody B cells CD4 T cells CD8 T cells cellular cellular component coronavirus COVID-19 COVID-19 vaccine COVID-19 vaccines cross-sectional develop Extraordinary feature Head-to-head comparison help Hybrid immunity immune memory Infection infections knowledge long-lasting memory memory B memory B cells memory T memory T cells mRNA mRNA vaccines natural immunity other diseases protective immunity Protein protein vaccine provided Quantitative responses SARS-CoV-2 SARS-COV-2 infection Vaccine Vaccines [DOI] 10.1111/imr.13089 PMC 바로가기
A review on computational approaches that support the researches on traditional Chinese medicines (TCM) against COVID-19COVID-19에 대한 전통적인 중국 의약품 (TCM)에 대한 연구를 지원하는 계산 접근법에 대한 검토Review Published on 2022-09-012022-08-31 Journal: Phytomedicine : international journal of phytother [Category] 신약개발, 치료제, [키워드] antiviral agent Antiviral agents antiviral medication applied approach approaches article articles artificial intelligence AutoDock AutoDock vina category caused Chinese collected complex mechanism complex mechanisms Compound computational approach Computational approaches computational method contagious infection contagious infections COVID-19 database death Direct direct-acting Diseases disrupting Drug discovery effort eligible examined exclusion criteria Google Scholar Gromacs help highlight include Inclusion Knowledge-mining lead MD simulation Medicine molecular docking molecular mechanism Network-based approach other diseases Prevention and control Prophylactic provided required Research ResearchGate resource retrieved Science Science Direct Structure-based approach Support targets TCM TCMSP Traditional Traditional Chinese medicine traditional Chinese medicine (TCM) Vaccine Web of Science [DOI] 10.1016/j.phymed.2022.154324 PMC 바로가기 [Article Type] Review
A Long-Term Comparison of Presenting Characteristics of Children with Newly Diagnosed Type 1 Diabetes Before and During the COVID-19 PandemicArticle Published on 2022-08-252022-11-15 Journal: Journal of clinical research in pediatric endocrinology [Category] 진단, [키워드] Admission age antibody autoantibody C-peptide Characteristics Child childhood children Clinical characteristics Contact Coverage COVID-19 diabete diabetes Diabetes Mellitus Diabetic diabetic ketoacidosis diagnosed Diagnosis Diseases duration of symptom Frequency group healthcare service hemoglobin Hospital stay Infection investigated Laboratory less morbidity and mortality no difference not differ other disease other diseases pandemic Patient polymerase chain presenting provide raise raised risk severity Sex significantly higher significantly lower significantly shorter Symptom T1D T1D patient the patient Thyroid tissue Transmission two group Type type-1 diabetes. were recorded [DOI] 10.4274/jcrpe.galenos.2022.2021-10-2 PMC 바로가기
Ongoing Mycophenolate Treatment Impairs Anti-SARS-CoV-2 Vaccination Response in Patients Affected by Chronic Inflammatory Autoimmune Diseases or Liver Transplantation Recipients: Results of the RIVALSA Prospective Cohort진행중인 미코페놀레이트 치료는 만성 염증성 자가면역 질환 또는 간 이식 수혜자의 영향을 받는 환자에서 항-SARS-CoV-2 백신 반응을 손상시킵니다: RIVALSA 예상 코호트의 결과Observational Study Published on 2022-08-122022-09-11 Journal: Viruses [Category] SARS, 임상, 진단, 치료기술, [키워드] 95% CI administration Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG anti-SARS-CoV-2 vaccination Antibody Response Antibody titers ARMS Arthritis Autoimmune Autoimmune disease Autoimmune diseases Autoimmune hepatitis calcineurin calcineurin inhibitors chronic cohort of patients Complete connective tissue disease Connective tissue diseases detectable develop Diagnosis dose dose reduction Effect effective Eligible patients enrolled evaluate evaluated example first dose healthy subjects hepatology identify IgG immunogenicity immunosuppressive immunosuppressive therapy Immunosuppressive treatment independent predictor independent predictors individual inhibitor liver liver transplant Liver transplantation MMF mRNA COVID-19 vaccine mRNA COVID-19 vaccines mRNA vaccine mRNA-based Multivariate analysis mycophenolate mycophenolate. neoplasia Novara observational study organ other diseases overlapped Patient patients performed predictor Prevent Prospective prospective observational study receiving recipients rejection required response Result rheumatoid arthritis rheumatological SARS-COV-2 infection selected Seroconversion seroconversion failure spondyloarthritis subgroups of patient suffered Suspension Tertiary therapy transplantation transplants treated Treatment unit Univariate analysis university vaccinated individual vaccination Vaccine vaccine response Vasculitis [DOI] 10.3390/v14081766 PMC 바로가기 [Article Type] Observational Study
Heterogeneous impact of Covid-19 response on tuberculosis burden by age group Research Published on 2022-08-122022-10-05 Journal: Scientific Reports [Category] 치료법, [키워드] affected age baseline Care caused COVID-19 COVID-19 pandemic death deaths decrease disease dominant Health Service incidence influence Korean MONITOR Mortality nine occur other diseases predicted progression reduced reduction significantly social distancing South Korea Transmission Tuberculosis would increase [DOI] 10.1038/s41598-022-18135-6 [Article Type] Research
Should RECOVERY have used response adaptive randomisation? Evidence from a simulation studyRandomized Controlled Trial Published on 2022-08-062022-10-04 Journal: BMC Medical Research Methodology [Category] SARS, 임상, [키워드] adaptive adaptive randomisation Adaptive trial Arm ARMS Care Community coronavirus COVID-19 COVID-19 mortality COVID-19 therapy defined Dexamethasone effective error rate estimate exhibiting FIVE fixed form hospitalised Hydroxychloroquine induce Lopinavir-ritonavir lower mortality Measures mortality rate other diseases Patient patient death patient subgroup performed Platform trial question randomisation randomised controlled trial Randomised Evaluation receiving recovery RECOVERY trial reduced reducing reduction REMAP-CAP representing Respiratory Support Response-adaptive randomization Simulation standard care Statistical power tested Treatment Trial Two-arm [DOI] 10.1186/s12874-022-01691-w PMC 바로가기 [Article Type] Randomized Controlled Trial
Definition of factors associated with negative antibody response after COVID-19 vaccination in patients with hematological diseases혈액 질환 환자에서 코로나19 백신 접종 후 항체 음성 반응과 관련된 요인 정의Article Published on 2022-08-012022-09-12 Journal: Annals of Hematology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] active treatment addition age Analysis antibody Antibody Response AstraZeneca BNT162b2 BTK inhibitor CML Combination Concentration correlated COVID-19 COVID-19 vaccination Definition demonstrated disease Efficacy Factor had no hematological Hematological diseases/disorders high mortality knowledge leukemia lymphoid median age Moderna mRNA-1273 naïve negative antibody response neoplasm Neoplasms not correlated other disease other diseases Patient patient cohort positive positive response reduced response to vaccination ruxolitinib SARS-CoV-2 Seroconversion significantly single-center study Spike protein Surveillance the SARS-CoV-2 therapy treated Treatment vaccination was performed were measured women [DOI] 10.1007/s00277-022-04866-z PMC 바로가기 [Article Type] Article
Predicting the outcome for COVID-19 patients by applying time series classification to electronic health recordsObservational Study Published on 2022-07-172022-10-04 Journal: BMC Medical Informatics and Decision Making [Category] 임상, [키워드] Accuracy Asymptomatic Brazil caused conducted COVID-19 COVID-19 patient death develop diagnose discharge Diseases Electronic health record evaluated help Hospitalization Infection Laboratory test machine learning model mild symptoms Observational cohort study other diseases outcome Outcome prediction Patient predict Research Result sensitivity severe disease specificity Support time Time series classification Vital vital sign vital signs were used [DOI] 10.1186/s12911-022-01931-5 PMC 바로가기 [Article Type] Observational Study