Genomic surveillance: Circulating lineages and genomic variation of SARS-CoV-2 in early pandemic in Ceará state, Northeast BrazilArticle Published on 2022-11-012022-11-16 Journal: Virus research [Category] SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] B.1 B.1.1 B.1.1.28 B.1.1.33 Brazil circulating compose COVID-19 dataset death rate genetic diversity Genome Genome sequences genomes sequenced genomic genomic variation GISAID database impacted Lineage Missense Missense mutations Mutation mutations Other lineage P.1 P.2 pandemic polymorphism prevalent prevalent lineage SARS-CoV-2 SARS-CoV-2 sequencing sequence sequenced single-nucleotide SNPs Surveillance synonymous virus [DOI] 10.1016/j.virusres.2022.198908 PMC 바로가기
Brief dispersion of a putative B.1.1.28-derived SARS-CoV-2 lineage harboring additional N234P and E471Q spike protein mutations in individuals crossing the Argentina-Brazil borderArticle Published on 2022-09-012022-11-16 Journal: Travel medicine and infectious disease [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] analyzed B.1.1.28 Brazil cause COVID-19 epidemiological data FASTQ fluctuation Frequency Gamma genomic hospital Illumina individual Inpatient Lineage Local Mutation P.1 P.2 performed phylogenetic inference platform Porto positive sample representing Rio Grande SARS-CoV-2 SARS-CoV-2 lineage Spike protein spread to state variant variant calling analysis variants virus VoC whole-genome sequencing [DOI] 10.1016/j.tmaid.2022.102390 PMC 바로가기
Genomic epidemiology of the SARS-CoV-2 epidemic in Brazil Research Published on 2022-08-182022-10-05 Journal: Nature Microbiology [Category] SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] absence Brazil characterized country COVID-19 case death effective Epidemic Epidemiology Europe Evidence Gamma Genome genomic Latin America Lineage Local Measures National P.1 P.2 pandemic progressed SARS-CoV-2 SARS-CoV-2 variants Spread Surveillance sustained the epidemic the SARS-CoV-2 Transmission transmission cluster variant variants of concern viral lineage virus transmission [DOI] 10.1038/s41564-022-01191-z [Article Type] Research
First importations of SARS-CoV-2 P.1 and P.2 variants from Brazil to Spain and early community transmission브라질에서 스페인으로 SARS-CoV-2 P.1 및 P.2 변종 최초 수입 및 초기 지역사회 전파Article Published on 2022-05-012022-09-11 Journal: Enfermedades infecciosas y microbiologia clinica ( [Category] COVID19(2023년), SARS, 변종, [키워드] Asymptomatic B.1.1.7 B.1.351 Brazil circulating Community community transmission COVID-19 described distribution E484K E484K mutation English hospitalisation household transmission identify Importación importation information involved P.1 P.1 variant P.2 P.2 variant P.2 variants P1 P2 positive random random selection remained required Rio de Janeiro SARS-CoV-2 South Africa Spain Spanish Travel Travellers variant Viajeros. VoC was performed Whole genome sequencing [DOI] 10.1016/j.eimce.2021.05.015 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Variants in Paraguay: Detection and Surveillance with an Economical and Scalable Molecular Protocol파라과이의 SARS-CoV-2 변종: 경제적이고 확장 가능한 분자 프로토콜을 통한 탐지 및 감시Article Published on 2022-04-222022-09-11 Journal: Viruses [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Alpha Amplicon B.1.1.7 detect detection develop Genotype IMPROVE K417 Lambda Lineage lineages Mutation Nanopore nanopore sequencing nasopharyngeal sample P.1 P.2 Paraguay positive protocol real-time RT-PCR resources rRT-PCR Sample Sanger sequencing SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Sequencing SNP spike spike mutation spike mutations subset Surveillance tested the SARS-CoV-2 the Spike variant variant call variant calls variants whole-genome whole-genome sequencing Zeta [DOI] 10.3390/v14050873 PMC 바로가기 [Article Type] Article
Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvirSARS-CoV-2 변이체의 주요 프로테아제 돌연변이체는 여전히 니르마트렐비르에 감수성입니다Article Published on 2022-04-152022-09-11 Journal: Bioorganic & medicinal chemistry letters [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] anticipated antiviral agent Antiviral agents B.1.1.529 B.1.351 Beta catalytically competent Coronaviral COVID-19 COVID-19 pandemic drug target Effectiveness Efficacy expressed in vitro data inhibitor inhibitors Lambda M pro main protease Missense mutation Multiple multiple mutations mutant Mutation Nirmatrelvir not compromised omicron P.2 PF-07321332 prevalent protease public health threat SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 variant Specific Spike protein susceptible the spike protein Vaccines variant variants variants of SARS-CoV-2 wildtype [DOI] 10.1016/j.bmcl.2022.128629 PMC 바로가기 [Article Type] Article
The Role of Spike Protein Mutations in the Infectious Power of SARS-COV-2 Variants: A Molecular Interaction PerspectiveSARS-COV-2 변이체의 전염력에서 스파이크 단백질 돌연변이의 역할: 분자 상호작용 관점Article Published on 2022-04-052022-09-11 Journal: Chembiochem [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 receptor among others Analysis attachment B.1.1.28.1 B.1.351 bond Brazil correlated domain E484K mutation Effects Europe host cells hydrogen Hydrogen bond IMPROVE initial K417N molecular molecule molecules N501Y natural P.1 P.2 pair power quantum Quantum mechanics quantum theory RBD Receptor binding domain recognize reported residue residues role S477N Salt Bridge salt bridges SARS-CoV-2 virus significantly South Africa Specific spike Spike protein the spike protein theory United Kingdom variant virus wild type [DOI] 10.1002/cbic.202100393 PMC 바로가기 [Article Type] Article
In silico analysis of mutant epitopes in new SARS-CoV-2 lineages suggest global enhanced CD8+ T cell reactivity and also signs of immune response escape새로운 SARS-CoV-2 계통에서 돌연변이 에피토프의 실리코 분석은 전 세계적으로 향상된 CD8+ T 세포 반응성과 면역 반응 탈출의 징후를 시사합니다Article Published on 2022-04-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법, [키워드] Analysis antibody B.1.1.7 B.1.351 binding Binding prediction Brazil CD8+ CD8+ T cell CD8+ T cell response CD8+ T cells change class Class I HLA conserved country Coverage COVID-19 E484K epitope Epitopes evade Evidence exhibiting expected fraction highlight HLA allele HLA alleles HLA binding immune response immunogenic in silico individual investigated Lineage lineages mutant Mutation N501Y new SARS-CoV-2 P.1 P.2 peptide peptides predicted provided reactivity reference sequence respond response SARS-CoV-2 SARS-CoV-2 variants silico predictions South Africa spike T cell T cell epitopes T cells TCR Transmissibility variant variants variants of concern Viral load [DOI] 10.1016/j.meegid.2022.105236 PMC 바로가기 [Article Type] Article
SARS-CoV-2 variant detection with ADSSpikeADSSpike를 사용한 SARS-CoV-2 변이체 감지Article Published on 2022-03-012022-09-11 Journal: Diagnostic microbiology and infectious disease [Category] SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] Amplicon Amplicon deep sequencing average clinical laboratory COVID-19 pandemic decrease deep sequencing Deletion deletions diagnose Diagnosis genomic Genomic surveillance global pandemic identify imperative Laboratory Mutation new SARS-CoV-2 P.2 pandemic Prevalence public health measure public health measures reaction S gene SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 mutants SARS-CoV-2 variant SARS-CoV-2 variants sequenced SNP Surveillance variants variants of concern variants of interest Viral transmission [DOI] 10.1016/j.diagmicrobio.2021.115606 PMC 바로가기 [Article Type] Article
The B.1.427/1.429 (epsilon) SARS-CoV-2 variants are more virulent than ancestral B.1 (614G) in Syrian hamstersB.1.427/1.429(엡실론) SARS-CoV-2 변종은 시리아 햄스터의 조상 B.1(614G)보다 더 치명적입니다.Research Article Published on 2022-02-102022-09-10 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] addition airway airways Alpha animal models Antibody neutralization B.1 B.1.1.7 B.1.351 B.1.427 B.1.429 Beta body weight Body weight loss Brazil Clinical data convalescent patient Convalescent patients Critical determine dissemination Efficiency Epsilon evade experiments explain hamster hamsters help highest Human human population in vitro India Infection infections late stage lineages lung Lungs maintain moderate nasal Nasal cavity New observé oral swab oral swabs Oropharyngeal oropharynx P.1 P.2 parenchyma plasma pre-existing immunity recipients replicate Replication SARS-CoV-2 variant SARS-CoV-2 variants severe disease severe lung pathology sgRNA shown significant difference significant differences South Africa Spread susceptibility Transmissibility Transmission Vaccine Vaccine-induced immunity variant variants variants of SARS-CoV-2 Viral Viral RNA virulence virulent weight loss Zeta [DOI] 10.1371/journal.ppat.1009914 PMC 바로가기 [Article Type] Research Article