P-glycoprotein
[용어속성] Term
Ivermectin: a mini-review
Review
[키워드] Avermectin
COVID-19
Ivermectin
P-glycoprotein
poisoning
[DOI] 10.1080/15563650.2022.2043338 [Article Type] Review
[DOI] 10.1080/15563650.2022.2043338 [Article Type] Review
In silico analysis of the interactions of certain flavonoids with the receptor-binding domain of 2019 novel coronavirus and cellular proteases and their pharmacokinetic properties
특정 플라보노이드와 2019년 신종 코로나바이러스 수용체 결합 도메인의 상호작용 및 세포성 프로테아제 및 이들의 약동학적 특성에 대한 실리코 분석
Article
Published on
Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 치료제,
Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 치료제,
[키워드] 2019
2019 novel coronavirus
2019-nCoV
acute respiratory syndrome coronavirus
Analysis
binding
blood-brain barrier
cathepsin B
caused
cellular protease
cellular proteases
Compound
conducted
coronavirus 2
coronavirus disease
Coronavirus disease 2019
COVID-19
death
drug-likeness
eukaryotic cells
evaluated
FIVE
flavonoid
flavonoids
gallate
glycoprotein
hepatotoxicity
hydrogen
Hydrogen bond
inhibit
Interaction
interactions
microorganism
MM/PBSA
molecular
molecular docking
molecular dynamics
Molecular mechanics
nCoV
P-glycoprotein
pharmacokinetic
Protein
Proteins
RBD
Receptor binding domain
respiratory
SARS-CoV-2
Serine
serine protease
severe acute respiratory syndrome Coronavirus
severe acute respiratory syndrome coronavirus 2
spike glycoprotein
subgroup
substrate
supported
surface area
target proteins
the receptor-binding domain
TMPRSS2
Toxicity
transmembrane serine protease
transmembrane serine protease 2
Van
[DOI] 10.1080/07391102.2020.1840444 PMC 바로가기 [Article Type] Article
[DOI] 10.1080/07391102.2020.1840444 PMC 바로가기 [Article Type] Article
Molecular modelling studies unveil potential binding sites on human serum albumin for selected experimental and in silico COVID-19 drug candidate molecules
Research article
[키워드] analyzed
approach
Arbidol
bind
binding
binding energy
binding free energy
binding site
blood plasma
calculated
Carmofur
complexes
Compound
compounds
coronavirus disease
COVID-19
daclatasvir
demonstrated
dihydroergotamine
disulfiram
drug
drug candidate
Effects
evaluate
geometric
HAS
Human
Human serum albumin
Hydrogen bond
hydrophobic interactions
identify
in silico
inhibitor
interacting residue
mechanism
MM/PBSA
moderate
molecular
molecular docking
Molecular dynamics simulation
molecular interaction
Molecular mechanics
P-glycoprotein
P450
paritaprevir
permeation
Pharmacodynamics
pharmacokinetic
pharmacokinetics
pharmacological
prevalent
Protein
saquinavir
selected
serum albumin
Serum protein
stability
therapeutic
therapeutic molecules
were used
[DOI] 10.1016/j.sjbs.2021.09.042 [Article Type] Research article
[DOI] 10.1016/j.sjbs.2021.09.042 [Article Type] Research article
Drugs repurposed: An advanced step towards the treatment of breast cancer and associated challenges
Review article
[키워드] coiled-coil-containing protein kinase 1
17β-HSD17β-Hydroxysteroid dehydrogenase specificity
17β-Hydroxysteroid dehydrogenase specificity
3β-HSD3β-Hydroxysteroid dehydrogenase specificity
3β-Hydroxysteroid dehydrogenase specificity
4-Hydroxy-trans-2-NonEnal
8-Oxo-2'-deoxyguanosine
8-Oxo-dG8-Oxo-2'-deoxyguanosine
AAArachidonic acid
ABCATP Binding Cassette
ABCG2ATP-binding cassette superfamily G member 2
active transport
adverse effect
AEadverse effect
ALSAmyotrophic lateral sclerosis
Amyotrophic lateral sclerosis
anthracyclines
arachidonic acid
ATactive transport
ATP Binding Cassette
ATP-binding cassette superfamily G member 2
BCBreast cancer
beta actin
BRAC1breast cancer type 1
Breast
Breast cancer
breast cancer type 1
Cancer
cancer causing genes
Cancer stem cells
cancerous cells
candidate
CCcancerous cells
CCGscancer causing genes
CDKcyclin-dependent kinase
clinical trials
complications
Computational approaches
costly
COX-2Cyclo-oxygenase 2
CSCscancer stem cells
CTsclinical trials
cyclin-dependent kinase
Cyclo-oxygenase 2
DBFdrug binding frequency
DBSdrug binding site
death
Dehydroepiandrosterone
Dehydroepiandrosterone sulfate
DHEADehydroepiandrosterone
DHEASDehydroepiandrosterone sulfate
Di phosphomevalonate decarboxylase
Diabetes Mellitus
DIdrug induced
DMDiabetes mellitus
DNA Topoisomerase II Alpha
DRdrug resistance
drug
drug binding frequency
drug binding site
drug induced
drug resistance
drug transporters
DTsdrug transporters
ECMextra cellular matrix
EHRselectronic health records
Electronic health records
EMTEpithelia-Mesenchymal transition
EP1prostaglandin E2 receptor 1
Epithelia-Mesenchymal transition
ER+Estrogen Receptor-Positive
ERCC2Excision repair cross-complementing group 2
EREsestrogen receptor binding elements
ERestrogen receptor
ERKextracellular signal-regulated kinases
estrogen receptor
estrogen receptor binding elements
Estrogen Receptor-Positive
Excision repair cross-complementing group 2
extra cellular matrix
extracellular signal-regulated kinases
Factors
FAKfocal adhesion kinase
focal adhesion kinase
glutathione S-transferase
Glycogen synthase kinase 3 beta
GSKβGlycogen synthase kinase 3 beta
GSTglutathione S-transferase
H-rasHarvey Rat sarcoma virus
Harvey Rat sarcoma virus
HDHuntington disease
HER1/2Human epidermal growth factor receptor 1/2
HER2-Human Epidermal growth factor receptor 2 negative
HER2+Human Epidermal growth factor receptor 2 positive
HERhuman epidermal growth factor receptor
HMG-CoA reductase
HMG-CoA Synthase
HMGCRHMG-CoA reductase
HMGCSHMG-CoA Synthase
HNE4-Hydroxy-trans-2-NonEnal
HPTHypertension
human epidermal growth factor receptor
Human epidermal growth factor receptor 1/2
Human Epidermal growth factor receptor 2 negative
Human Epidermal growth factor receptor 2 positive
Huntington disease
hypertension
IBDInflammatory bowel disease
IGF-1insulin-like growth factor 1
Inflammatory bowel disease
information
inhibitor
insulin-like growth factor 1
Lanosterol synthase
LHRHluteinizing hormone-releasing hormone
LSSLanosterol synthase
luteinizing hormone-releasing hormone
malignant cells
malondialdehyde
mammalian target of rapamycin
MAPKmitogen- activated protein kinase
matrix metalloproteinase
MCmalignant cells
MDAmalondialdehyde
MDmedian duration
MDRmulti-drug resistance
median duration
membrane transporters
MetAP2methionine aminopeptidase-2
methionine aminopeptidase-2
MHS2MutS Homolog 2
microtubules
mitogen- activated protein kinase
mitoxantrone resistant cells
MLH1MutL homolog 1
MMPmatrix metalloproteinase
molecular mechanism
Mortality
MRCmitoxantrone resistant cells
MTmicrotubules
mTORmammalian target of rapamycin
MTsmembrane transporters
multi-drug resistance
MutL homolog 1
MutS Homolog 2
MVDDi phosphomevalonate decarboxylase
NAD(P)H dehydrogenase [quinone] 1
NCCnon-cancerous cells
NCENew chemical entity
New chemical entity
NF-κBNuclear factor kappa-light-chain-enhancer of activated B cell
Nitric Oxide Synthase 3
non-cancerous cells
Non-profit organisations
non-steroidal anti-inflammatory medicine
NOS3Nitric Oxide Synthase 3
NPONon-profit organisations
NQO1NAD(P)H dehydrogenase [quinone] 1
NSAIDnon-steroidal anti-inflammatory medicine
Nuclear factor kappa-light-chain-enhancer of activated B cell
occur
OCT1organic cation transporter 1
organic cation transporter 1
P-glycoprotein
P-gpP-glycoprotein
p53Tumor protein p53
PEG2/PGH2prostaglandin E2
PR+Progesterone Positive
Progesterone Positive
progesterone receptor
prostaglandin E2
prostaglandin E2 receptor 1
proteomics
provide
PRprogesterone receptor
Rac1Ras-related C3 botulinum toxin substrate 1
Randomised clinical trials
Ras homolog family member A
Ras-related C3 botulinum toxin substrate 1
RCTsRandomised clinical trials
reactive oxygen species
Receptor tyrosine kinase
Repurposed drug
responsible
Rho-ARas homolog family member A
rho-associated
Ribosomal protein S6 kinase
rising
ROCK1rho-associated
ROSreactive oxygen species
RTKReceptor tyrosine kinase
S6KRibosomal protein S6 kinase
Scientific community
SCstromal cells
SCTssolute carrier transporters
selective estrogen receptor degrader
selective estrogen receptor modulator
sequential strategies
SERDselective estrogen receptor degrader
SERM
Side effects
signal transducer and activator of transcription 3
SIRT1/2sirtuin (silent mating type information regulation 2 homolog) ½
sirtuin (silent mating type information regulation 2 homolog) ½
SLC22A16Solute Carrier Family 22 Member 16
SMAD 2/3/4SMAD family member 2/3/4
SMAD family member 2/3/4
Solute Carrier Family 22 Member 16
solute carrier transporters
Sp1/3/4specificity protein 1/3/4
specificity protein 1/3/4
SQLESqualene monooxygenase
Squalene monooxygenase
SSsequential strategies
STAT3signal transducer and activator of transcription 3
stromal cells
subject
survival
TAEtopoisomerase alteration expression
Tamoxifen
TAMTamoxifen
TCtumour cells
TGFαTransforming growth factor-alpha
TGFβ-RITransforming growth factor-beta type 1 receptor
TGFβ1/β2Transforming growth factor beta1/2
TOP2ADNA Topoisomerase II Alpha
topoisomerase alteration expression
TP53tumor protein
Transforming growth factor beta1/2
Transforming growth factor-alpha
Transforming growth factor-beta type 1 receptor
Treatment
treatment-related side effects
TRPtumour resistance profile
TSEtreatment-related side effects
tumor protein
Tumor protein p53
tumour cells
tumour resistance profile
vascular endothelial growth factor
VEGFvascular endothelial growth factor
women
xanthine dehydrogenase
XDHxanthine dehydrogenase
β-actbeta actin
[DOI] 10.1016/j.biopha.2021.112375 [Article Type] Review article
[DOI] 10.1016/j.biopha.2021.112375 [Article Type] Review article
Drug-induced Liver Injury in a Patient With Coronavirus Disease 2019: Potential Interaction of Remdesivir With P-Glycoprotein Inhibitors
2019년 코로나바이러스 질환 환자의 약물 유발 간 손상: 렘데시비르와 P-당단백질 억제제의 잠재적 상호작용
Case Reports
[키워드] COVID-19
drug-induced
drug–drug interaction
hepatotoxicity
inhibitor
inhibitors
Interaction
P-glycoprotein
Patient
physician
Potential
prescription
receiving
Remdesivir
therapy
with COVID-19
[DOI] 10.1093/cid/ciaa883 PMC 바로가기 [Article Type] Case Reports
[DOI] 10.1093/cid/ciaa883 PMC 바로가기 [Article Type] Case Reports
Predictive association of ABCB1 C3435T genetic polymorphism with the efficacy or safety of lopinavir and ritonavir in coronavirus disease-2019 patients
Review
[키워드] ABCB1 genetic polymorphism
ABCB1
affected
America
Asia
association
coronavirus
COVID-19
COVID-19 patient
drug
Efficacy
Europe
Genetic polymorphism
genetic variability
glycoprotein
Lopinavir
Lopinavir/ritonavir
P-glycoprotein
Patient
phenotype
Phenotypes
predicted
prevalent
proportion
risk
Ritonavir
safety and efficacy
substrate
therapeutic
Toxicity
treated
[DOI] 10.2217/pgs-2020-0096 PMC 바로가기 [Article Type] Review
[DOI] 10.2217/pgs-2020-0096 PMC 바로가기 [Article Type] Review
A Comparative Analysis of SARS-CoV-2 Antivirals Characterizes 3CL pro Inhibitor PF-00835231 as a Potential New Treatment for COVID-19
Vaccines and Antiviral Agents
[키워드] 3CL pro
A549
ACE2
acute respiratory syndrome
airway
airway epithelium
alveolar
Analysis
Antiviral
Antiviral compound
antiviral drug
approach
approved
Cell
cells
clades
clinical trials
Comparative
complex
component
concentrations
coronavirus
coronavirus disease
COVID-19
cultures
develop
direct-acting
drug candidate
effective
Efficacy
epithelial
epithelial cell
etiological agent
Evidence
experiment
Express
GC-376
Human airway epithelium
human airway epithelium cultures
in vitro
in vitro model
inhibit SARS-CoV-2
inhibitor
kidney
M pro
New
P-glycoprotein
polymerase
polyprotein
Potential
protease
provide
regimen
Remdesivir
SARS-CoV-2
SARS-CoV-2 life cycle
SARS-CoV-2 protease
Side effect
suggested
targets
the SARS-CoV-2
the timing
time-of-addition experiments
treat
VERO E6 cells
viral life cycle
[DOI] 10.1128/JVI.01819-20 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents
[DOI] 10.1128/JVI.01819-20 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents