Nanobioelectrocatalysis Using Human Liver Microsomes and Cytochrome P450 Bactosomes: Pyrenyl-Nanocarbon Electrodesarticle Published on 2024-03-032024-09-05 Journal: ACS applied bio materials [Category] update2024, [키워드] amine-nanotubes bioelectrodes electrocatalysis liver microsomes P450 pi–pi stacking pyrenylamine [DOI] 10.1021/acsabm.3c01170 PMC 바로가기 [Article Type] article
Safety, Tolerability, and Pharmacokinetics of the Novel Antiviral Agent Ensitrelvir Fumaric Acid, a SARS-CoV-2 3CL Protease Inhibitor, in Healthy AdultsArticle Published on 2022-10-182022-11-15 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CL acid administration adverse event affected agent Antiviral assessment AUC C max COVID-19 demonstrated dose doses drug-drug interaction Effect ensitrelvir first-in-human Food Intake geometric increase in Infection inhibitor Japanese mild in severity MOST novel oral dosing P450 participant Participants participants with SARS-CoV-2 pharmacokinetics phase 1 study Placebo plasma proportionality protease Protease inhibitor Randomized reduced resolved Safety SARS-CoV-2 selective single dose substrate T max Tolerability Treatment viral replication [DOI] 10.1128/aac.00632-22 PMC 바로가기
Paxlovid (Nirmatelvir/Ritonavir) and Tacrolimus Drug-Drug Interaction in a Kidney Transplant Patient with SARS-2-CoV infection: A Case ReportArticle Published on 2022-07-012022-11-15 Journal: Transplantation proceedings [Category] COVID19(2023년), SARS, 치료제, [키워드] Acute kidney injury acute respiratory syndrome addition adverse effects Affect antiviral medication approved Awareness Case report Combination Community Consulting coronavirus disease dose drug-drug interaction Efficiency Emergency use enzyme health systems Immunocompromised patient Immunosuppressive medication increase induce inhibit inhibitor interactions kidney transplant medication metabolites New P450 pandemic Patient Paxlovid physician Prevent receive receiving recipient reduction rejection report risk Ritonavir robust SARS-CoV-2 serum creatinine Side effects Symptoms tacrolimus tested Transplant treat treated Treatment [DOI] 10.1016/j.transproceed.2022.04.015 PMC 바로가기
Benzo[ a]pyrene-Environmental Occurrence, Human Exposure, and Mechanisms of Toxicity벤조[a]피렌-환경 발생, 인체 노출 및 독성 메커니즘Review Published on 2022-06-062022-09-11 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, [키워드] aromatic hydrocarbon association benzo[a]pyrene carcinogenic carcinogenicity cause cigarette smoke concerning COVID-19 pandemic cytochrome P450 determine DNA epoxy Evidence exhibit exposure exposure to expressed facilitate genotoxicity Human impairment involved mechanism metabolism multiplication Mutation neurotoxic Occurrence organism P450 polycyclic polycyclic aromatic hydrocarbons. polymorphism pyrene receptor sensitivity Soil Surface water teratogenic toxic effect toxic effects Toxicity turn viruses water widespread xenobiotics [DOI] 10.3390/ijms23116348 PMC 바로가기 [Article Type] Review
Physiologically-Based Pharmacokinetic-Led Guidance for Patients With Cystic Fibrosis Taking Elexacaftor-Tezacaftor-Ivacaftor With Nirmatrelvir-Ritonavir for the Treatment of COVID-19낭포성 섬유증 환자를 위한 생리학적 기반 약동학 주도 지침Article Published on 2022-06-012022-09-11 Journal: Clinical Pharmacology and Therapeutics [Category] 변종, [키워드] Administered approach AUC CFTR Combination coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection Cystic cystic fibrosis cytochrome P450 Day decrease dose drug interaction drug-drug interaction elexacaftor eliminated evaluated fibrosis independent information inhibited inhibiting inhibitor inhibitory effect ivacaftor metabolism modeling modulating Nirmatrelvir P450 parameter pharmacokinetic pharmacokinetics physiological predict predicted reduced regimen risk Ritonavir Simulation Taking tezacaftor therapeutic Therapies transmembrane Treatment was performed [DOI] 10.1002/cpt.2585 PMC 바로가기 [Article Type] Article
Dexamethasone is a dose-dependent perpetrator of drug-drug interactions: implications for use in people living with HIVDexamethasone은 약물-약물 상호작용의 용량 의존적 가해자입니다.Article Published on 2022-02-232022-09-11 Journal: Journal of Antimicrobial Chemotherapy [Category] COVID19(2023년), SARS, 치료제, [키워드] antiretroviral ARV assessment complex Course COVID-19 patient CYP3A4 cytochrome P450 daily dose Dexamethasone dosage dose-dependent drug-drug interaction drugs evaluated implication in vitro in vivo inducer inhibitor inhibitors Interaction management P450 recommendation substrate substrates Treatment victim with HIV [DOI] 10.1093/jac/dkab412 PMC 바로가기 [Article Type] Article
The Role of Cytochrome P450 Enzymes in COVID-19 Pathogenesis and TherapyPharmacology Published on 2022-02-022022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] affected Analysis arachidonic acid changes in Coronavirus disease 2019 COVID-19 CYP = cytochrome P450 cytochrome P450 death drug metabolism drugs dysregulated immune response Effect Eicosanoids endogenous enzyme Evidence expression fatty acids hormone immune response Inflammation metabolism multiple-organ failure P450 pathophysiological feature pathophysiology Patient public health crisis role SARS-CoV-2 severe COVID-19 Steroids therapeutic therapeutic agent toxins vitamins [DOI] 10.3389/fphar.2022.791922 PMC 바로가기 [Article Type] Pharmacology
Molecular modelling studies unveil potential binding sites on human serum albumin for selected experimental and in silico COVID-19 drug candidate moleculesResearch article Published on 2022-01-012022-10-05 Journal: Saudi Journal of Biological Sciences [Category] 신약개발, 치료제, [키워드] analyzed approach Arbidol bind binding binding energy binding free energy binding site blood plasma calculated Carmofur complexes Compound compounds coronavirus disease COVID-19 daclatasvir demonstrated dihydroergotamine disulfiram drug drug candidate Effects evaluate geometric HAS Human Human serum albumin Hydrogen bond hydrophobic interactions identify in silico inhibitor interacting residue mechanism MM/PBSA moderate molecular molecular docking Molecular dynamics simulation molecular interaction Molecular mechanics P-glycoprotein P450 paritaprevir permeation Pharmacodynamics pharmacokinetic pharmacokinetics pharmacological prevalent Protein saquinavir selected serum albumin Serum protein stability therapeutic therapeutic molecules were used [DOI] 10.1016/j.sjbs.2021.09.042 [Article Type] Research article
Impact of SARS-CoV-2 Infection (COVID-19) on Cytochromes P450 Activity Assessed by the Geneva CocktailClinical Trial Published on 2021-11-012022-10-05 Journal: Clinical Pharmacology and Therapeutics [Category] 임상, [키워드] activity Acute inflammation acute respiratory syndrome administration Blood C-reactive protein Capillary blood sample caused clinically cocktail collected conducted coronavirus Coronavirus disease 2019 COVID-19 CRP CYP1A2 CYP2B6 CYP2C19 CYP2C9 CYP2D6 cytochrome demonstrated Diagnosis evaluate expected Geneva University Hospital Hospitalization IL-6 Impact impacted Infection inflammatory state moderate modulate modulated MRS P450 patients patients hospitalized patients with COVID-19 prospective observational study SARS-CoV-2 SARS-COV-2 infection Serum level severe COVID-19 significantly statistical significance substrates Switzerland the disease TNF-α treat Treatment tumor necrosis factor-α Variation [DOI] 10.1002/cpt.2412 PMC 바로가기 [Article Type] Clinical Trial
Annelid genomes: Enchytraeus crypticus , a soil model for the innate (and primed) immune systemArticle Published on 2021-09-062022-10-29 Journal: Lab Animal [Category] COVID-19, MERS, SARS, [키워드] ACE ACE2 Annelid Annelida antibiotic Bioscience cell entry Combination coronavirus SARS-CoV-2 distribution elements Environmental sciences enzyme gene families Genes Genome Genomics highlight homolog horizontal gene identify Illumina immune system innate immune system Innate immunity Interaction invertebrate involved nuclear P450 platform Protein reference genome Sequencing Significant Stress transfer worm [DOI] 10.1038/s41684-021-00831-x PMC 바로가기 [Article Type] Article