The role of high cholesterol in SARS-CoV-2 infectivityResearch Article Published on 2023-04-282024-09-05 Journal: Brain stimulation [Category] update2024, [키워드] aging ApoE cholesterol COVID-19 diabetes furin GM1 imaging lipid membrane Lipid raft obesity palmitoylation PIP2 storm [DOI] 10.1016/j.jbc.2023.104763 PMC 바로가기 [Article Type] Research Article
Molecular Dynamics of DHHC20 Acyltransferase Suggests Principles of Lipid and Protein Substrate SelectivityArticle Published on 2022-05-032023-06-16 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, [키워드] acyl CoA DHHC-PATs molecular dynamics palmitoylation S-acylation [DOI] 10.3390/ijms23095091 PMC 바로가기 [Article Type] Article
Structure and dynamics of the SARS-CoV-2 envelope protein monomerArticle Published on 2022-05-012023-07-08 Journal: Proteins [Category] COVID19(2023년), [키워드] envelope protein glycosylation membrane curvature membrane protein molecular dynamics palmitoylation SARS-CoV-2 [DOI] 10.1002/prot.26317
Identification of SARS-CoV-2 Spike Palmitoylation Inhibitors That Results in Release of Attenuated Virus with Reduced Infectivity감소된 감염성과 함께 약독화된 바이러스의 방출을 초래하는 SARS-CoV-2 스파이크 팔미토일화 억제제의 식별Article Published on 2022-03-042022-09-11 Journal: Viruses [Category] SARS, 변종, [키워드] acylation Antiviral antivirals biogenesis bis-piperazine C-terminal cysteine cysteine residue cytoplasmic DHHC9 domain ER and Golgi FIVE fusion Glycoproteins Golgi identification Infection Infectivity inhibit SARS-CoV-2 inhibitor interact Intervention knockdown membrane fusion palmitate palmitoylation palmitoyltransferase palmitoyltransferase inhibitor Particle piperazine post-translational modifications progeny virion Protein reduced Release released Result resulting S protein S-acylation SARS-CoV-2 SARS-CoV-2 S protein spike Spike mutant Spike protein Spike proteins the SARS-CoV-2 the spike protein transmembrane glycoprotein undergo virus [DOI] 10.3390/v14030531 PMC 바로가기 [Article Type] Article
The interactions of ZDHHC5/GOLGA7 with SARS-CoV-2 spike (S) protein and their effects on S protein’s subcellular localization, palmitoylation and pseudovirus entrySARS-COV-2 스파이크 (S)와 ZDHHC5/GOLGA7의 상호 작용 및 S 단백질의 세포 내 위치, 팔미 토일 화 및 슈도 바이러스 진입에 미치는 영향Research Published on 2021-12-272022-09-10 Journal: Virology Journal [Category] SARS, 치료기술, [키워드] A549 acute respiratory syndrome acute respiratory syndrome coronavirus Affect affected Affinity purification analyzed Antiviral APT2 assays Biotin Cas9 Cell cell line cell lines cell types cells co-immunoprecipitation co-IP Colocalization complex coronavirus CRISPR CRISPR-Cas9 cysteine cysteine residue determine domain Effect Efficiency endodomain enzymatic activity enzyme fluorescence microscopy GOLGA7 had no HEK293T HEK293T cell HEK293T cells Hela HeLa cells host protein host proteins independent independent of interact Interaction knowledge mass spectrometry no significant effect palmitoylation Protein provide pseudovirus entry reason Renilla Renilla luciferase respiratory Result S protein S proteins SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 S protein SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant effect significantly Spike protein subcellular localization the cell the S protein virus entry virus infection Virus-host interaction ZDHHC5 ZDHHC5/GOLGA7 [DOI] 10.1186/s12985-021-01722-w PMC 바로가기 [Article Type] Research
Crystalloids: Fascinating Parasite Organelles Essential for Malaria Transmissionarticle Published on 2021-07-312024-09-01 Journal: Trends in Parasitology [Category] 말라리아, [키워드] LCCL palmitoylation Sporogony transhydrogenase [Article Type] article
Palmitoylation of SARS-CoV-2 S protein is essential for viral infectivityLetter Published on 2021-06-112022-10-29 Journal: Signal Transduction and Targeted Therapy [Category] COVID-19, MERS, SARS, [키워드] Microbiology palmitoylation Pathogenesis SARS-CoV-2 S protein viral infectivity [DOI] 10.1038/s41392-021-00651-y PMC 바로가기 [Article Type] Letter
S-Acylation of Proteins of Coronavirus and Influenza Virus: Conservation of Acylation Sites in Animal Viruses and DHHC Acyltransferases in Their Animal ReservoirsArticle Published on 2021-05-292022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] 3D structure acylation Acyltransferase amino acid substitution animal caused Cluster conservation coronavirus CoV cysteine DHHC drugs E Evidence Evolution glycoprotein HA Host hosts human cells humans influenza A Influenza virus Localization M2 member Modification not affect overlapping palmitoylation pandemic preparedness Pandemics Protein provided recent Replication reservoir S-acylation SARS-CoV-2 Site specificity target vertebrates viral fitness virus viruses zoonotic origin [DOI] 10.3390/pathogens10060669 PMC 바로가기 [Article Type] Article
The Fatty Acid Lipid Metabolism Nexus in COVID-19COVID-19의 지방산 지질 대사 넥서스Review Published on 2021-01-112022-09-10 Journal: Viruses [Category] 치료제, [키워드] acid Activation acute respiratory syndrome Affect AMPK Antiviral assembly Clinical data complex coronavirus coronavirus protein Coronavirus replication COVID-19 COVID-19 immune response disease severity drugs endoplasmic reticulum stress response enteric envelope protein Evidence evidence of FASN fatty Fatty acid Formation Gut Immune homeostasis increase individual inhibit inhibition inhibitor Intervention intestine Lipid lipid metabolism liver mechanism membrane membrane protein metformin morbidly obese mTORC1 nexus nonstructural protein obese observation orlistat palmitoylation pancreas Protein protein kinase reduce Replication replicative organelle respiratory restoration Spike protein SREBP-1 systemic inflammation the disease therapeutic target unfolded protein response Viral viral replication virus replication [DOI] 10.3390/v13010090 PMC 바로가기 [Article Type] Review
New developments in probing and targeting protein acylation in malaria, leishmaniasis and African sleeping sicknessarticle Published on 2018-02-282024-09-01 Journal: Parasitology [Category] 말라리아, [키워드] acyl transferase N-myristoyl transferase NMT palmitoylation post-translational modification protein lipidation proteomics protozoan parasites small molecule inhibitor [Article Type] article