ACE2 function in the pancreatic islet: Implications for relationship between SARS‐CoV‐2 and diabetesReview Article Published on 2021-10-022022-10-27 Journal: Acta physiologica (Oxford, England) [Category] COVID-19, [키워드] ACE2 addition angiotensin‐converting enzyme 2 Beta cells Cell cell physiology cells COVID‐19 patient COVID‐19 diabete diabetes dissect Effect Endocrine enzyme expressed expression Factor Glucose glucose homoeostasis homoeostasis host cells in vitro infect Injury insulin Insulin sensitivity islet islets lung metabolism molecular molecular mechanism pancrea pancreatic pancreatic islet Pathogenesis pathophysiology Protein required SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2‐infected secretion suggested susceptibility therapeutic intervention triggered [DOI] 10.1111/apha.13733 PMC 바로가기 [Article Type] Review Article
ACE2 function in the pancreatic islet: Implications for relationship between SARS‐CoV‐2 and diabetesReview Article Published on 2021-10-022022-10-27 Journal: Acta physiologica (Oxford, England) [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] ACE2 addition angiotensin‐converting enzyme 2 Beta cells Cell cell physiology cells COVID‐19 patient COVID‐19 diabete diabetes dissect Effect Endocrine enzyme expressed expression Factor Glucose glucose homoeostasis homoeostasis host cells in vitro infect Injury insulin Insulin sensitivity islet islets lung metabolism molecular molecular mechanism pancrea pancreatic pancreatic islet Pathogenesis pathophysiology Protein required SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2‐infected secretion suggested susceptibility therapeutic intervention triggered [DOI] 10.1111/apha.13733 PMC 바로가기 [Article Type] Review Article
Identifying molecular insight of synergistic complexities for SARS-CoV-2 infection with pre-existing type 2 diabetes기존 제2형 당뇨병과 SARS-CoV-2 감염에 대한 시너지적 복잡성의 분자적 통찰력 확인Article Published on 2021-09-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 치료기술, [키워드] activities Analysis analyzed approaches association bioinformatics BIRC3 caused Cell Comorbidities Comorbidity conditions contributing to COVID-19 COVID-19 outbreak CREB3L1 cytokine cytokine receptor DEGs detect determine diabete diabetes differentially expressed gene Differentially expressed genes Disease progression drug drug candidate drug candidates Drug molecules enrichment enrichment analyses evaluated expressed Factor followed by FOSL1 Functional enrichment analysis Genetic genetic determinant genetic factors global public health Health identify identifying IL-17 IL1B Interaction IRF1 islet cell KLF11 let-7b-5p lung epithelium cell lung epithelium cells microRNA MicroRNAs miR-1 miRNA miRNAs MME molecular overlapped pancreatic pancreatic islet Pathways Patient PBMC PBMCs PPI prevalent protein-protein interaction protein–protein interactions receptor Research SARS-CoV-2 SARS-COV-2 infection severity severity of COVID-19 significant pathway significant pathways synergistic T2D TFS the disease therapeutic intervention TNF transcription factor transcription factors transcriptomic data Type type 2 diabete type 2 diabetes [DOI] 10.1016/j.compbiomed.2021.104668 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection of the pancreas promotes thrombofibrosis and is associated with new-onset diabetes췌장의 SARS-CoV-2 감염은 혈전 섬유증을 촉진하고 새로운 발병 당뇨병과 관련이 있습니다Research Article Published on 2021-08-232022-09-12 Journal: JCI Insight [Category] MERS, SARS, 진단, [키워드] ACE2 acute respiratory syndrome Admission angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 association Cell cell entry cells coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients data sets diabete diabetes died dysfunction endothelial Endothelial cell endothelial cells examined exhibited expression Factor female fibrosis humans Infection islet male NHP NHPs Occurrence pancrea pancreas pancreatic pancreatic islet Patient promote SARS-CoV-2 SARS-COV-2 infection Serine Severe acute respiratory syndrome Single-cell RNA sequencing thrombosis tissue TMPRSS2 transmembrane serine protease transmembrane serine protease 2 Vascular [DOI] 10.1172/jci.insight.151551 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 infection induces beta cell transdifferentiationSARS-CoV-2 감염은 베타 세포 전환분화를 유도합니다Clinical and Translational Report Published on 2021-08-032022-09-10 Journal: Cell Metabolism [Category] MERS, SARS, 치료기술, [키워드] Abstract acinar cell addition Alpha Antigen Autopsies Autopsy beta cell Beta cells cause Cell cell fate cell markers cellular cellular stress response chemokines Clinical data coronavirus disease Coronavirus disease 2019 correlation COVID-19 diabetes EgIF2 eIF2 example expression glucagon human islets immunostaining indicated individuals with COVID-19 induce Infection inhibitor insulin islet cell ISRIB lower expression pancreatic pancreatic islet Pathomechanism Pathomechanisms pathway phenotype provide PRSS1 recent reported reversed RNA sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral Single-cell RNA sequencing Stress stress response subject subjects suggested susceptible Trajectory analysis Tran trans trypsin 1 Viral Viral antigen [DOI] 10.1016/j.cmet.2021.05.015 PMC 바로가기 [Article Type] Clinical and Translational Report
The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severityResearch Article Published on 2021-06-282022-10-29 Journal: PLoS Pathogens [Category] COVID-19, MERS, SARS, [키워드] Alpha Caco-2 Calu-3 Calu-3 cell line Cell cell line cell type cells cellular entry cellular protease Chronic diseases Colon comorbid disease comorbid diseases Comorbidity Control Coronaviruses COVID-19 outbreak COVID-19 patient COVID-19 patients dataset datasets death decrease described determine diabete diabetic patient disease disease severity down-regulated down-regulation downregulated drastic reduction Endocrine evaluated example expression Factor Features Health implication increase in inhibit inhibiting inhibitor kidney knockdown liver malignancies mechanism New coronavirus number of infected overexpressing overexpression pancreatic islet pandemic patients priming regulated Regulation S protein SARS-CoV-2 SARS-CoV-2 viral infection scRNA-seq data secretory cell serine protease inhibitor serine protease TMPRSS2 severity shown similarity SPINT2 susceptibility tissues TMPRSS2 triggered Tumor Type unique viral entry Viral load virulence virus while [DOI] 10.1371/journal.ppat.1009687 PMC 바로가기 [Article Type] Research Article
Viral infiltration of pancreatic islets in patients with COVID-19COVID-19 환자에서 췌도의 바이러스 침투Article Published on 2021-06-102022-09-10 Journal: Nature Communications [Category] MERS, SARS, 바이오마커, 진단, 치료기술, 치료법, [키워드] absence ACE2 Autopsy Cell Complication comprehensive analysis contribute COVID-19 patient COVID-19 patients detectable diabete diabetes disease DPP4 dysregulation electron microscopy Endocrine examined expressed expression facilitate Factors hyperglycemia Immune cell infiltration immunofluorescence immunohistochemistry increased risk Infection infiltration islet cell islet cells mechanism metabolic Metabolic diseases Microscopy necroptotic cell death NRP1 pancreatic pancreatic beta-cell pancreatic beta-cells pancreatic islet patients patients with COVID-19 performed pseudoviruses receptor RNA SARS-CoV-2 SARS-CoV-2 pseudoviruses SARS-CoV-2 viral SARS-CoV-2 viral infection severe COVID-19 tissue TMPRSS vasculature Viral viral infection virus entry [DOI] 10.1038/s41467-021-23886-3 PMC 바로가기 [Article Type] Article
Islet organoid as a promising model for diabetesReview Published on 2021-03-102022-10-29 Journal: Protein & Cell [Category] COVID-19, COVID19(2023년), SARS, [키워드] abnormality autologous cellular contributing to diabete diabetes disease Disease model Drug screening effort functional heterogeneity immature IMPROVE in vitro Infection involved islet islet organoid islet transplantation islets lack mechanism Morphological organ Organoid organoids pancreatic β cell pancreatic islet pathological conditions pluripotent/adult stem cell regenerative SARS-CoV-2 STEM therapy virus [DOI] 10.1007/s13238-021-00831-0 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β CellsSARS-CoV-2 세포 진입 인자 ACE2 및 TMPRSS2는 인간 췌장의 미세혈관 및 관에서 발현되지만 β 세포에서는 풍부하지 않습니다Article Published on 2020-12-012022-09-11 Journal: Cell Metabolism [Category] Coronavirus, MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 ACE2 protein analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Beta beta cell binding canonical Cell cell entry cells co-expressed co-expression COVID-19 dataset defined diabete diabetes Donor donors duct ductal cells entry of SARS-CoV-2 exocrine tissue microvasculature expressed expression Factor Factors Human Hypothesis in vivo individuals with COVID-19 infect islet islet cell islet cells Isolated likelihood microvasculature pancrea pancreas pancreatic pancreatic ducts pancreatic islet pericyte pericyte. reduce SARS-CoV-2 Serine subset TMPRSS2 TMPRSS2 protein transcriptional transmembrane serine protease transmembrane serine protease 2 [DOI] 10.1016/j.cmet.2020.11.006 PMC 바로가기 [Article Type] Article
The relationship between hyperglycemia and the infection of COVID-19 in diabetic patients A protocol for systematic review and meta-analysis4900 Published on 2020-09-042022-10-30 Journal: Medicine [Category] COVID-19, SARS, [키워드] ACE2 receptor acute inflammatory reactions adverse effects bias risk binding blood glucose CBM Chinese clinical evidence clinical trial CNKI Cochrane Library combating Comorbidity COVID-19 COVID-19 epidemic COVID-19 infection Cytokine storms Data analysis database Diabetes Mellitus diabetic patient diabetic patients English fasting blood fasting insulin Glucose hemoglobin hyperglycemia include independent risk factor Infection Infectious disease Meta-analysis metabolic disease Mild pancreatic islet peer-reviewed Primary outcome protocol Randomized controlled trials Registration Regulation review risk factor RNA coronavirus SARS-COV-2 infection sensitivity analysis severe disease Severe infection single-stranded Stress Support systematic review VIP virus Web of Science [DOI] 10.1097/MD.0000000000021806 PMC 바로가기 [Article Type] 4900