Cross-Neutralization of SARS-CoV-2-Specific Antibodies in Convalescent and Immunized Human Sera against the Bat and Pangolin Coronaviruses박쥐 및 천산갑 코로나바이러스에 대한 회복기 및 면역화된 인간 혈청에서 SARS-CoV-2-특이적 항체의 교차 중화Article Published on 2022-08-162022-09-12 Journal: Viruses [Category] SARS, 진단, [키워드] ACE2 analyzed appear bat bat coronavirus binding Cell cell-cell fusion chimeric chimeric proteins contribute coronavirus COVID-19 COVID-19 patient cross-neutralize highest Human human ACE2 receptor human host immunized inactivated induce less neutralization neutralization activity neutralized Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody overexpressing pandemic pangolin pangolin coronavirus pangolins pre-existing immunity promote Protein pseudo-virus pseudo-virus. RaTG13 RBD replaced sarbecovirus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine serum sample significantly significantly higher spike the RBD the receptor-binding domain thought transmitted vaccination VeroE6 cells while widespread [DOI] 10.3390/v14081793 PMC 바로가기 [Article Type] Article
Conservation analysis of SARS-CoV-2 spike suggests complicated viral adaptation history from bat to humanOriginal Research Article Published on 2020-11-052022-11-01 Journal: Evolution, Medicine, and Public Health [Category] COVID-19, [키워드] acute respiratory syndrome analyses Analysis analyzed bat coronavirus RaTG13 carried caused conservation conservation analysis Contact coronavirus coronavirus disease coronavirus strains CoV COVID-19 domain GISAID groups Host identify Multiple sequence alignment N-terminal domain NCBI pandemic pangolin coronavirus pangolin CoV Phylogenetic plague public health emergency RaTG13 RBD Receptor-binding domain recombination event recombine Result reveal S2 subunit SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 spike sequence similarity spike strain Strains Transmission Variation viral adaptation virus was used whole-genome [DOI] 10.1093/emph/eoaa041 PMC 바로가기 [Article Type] Original Research Article