Paediatric orthopaedic surgery during the SARS-CoV-2 pandemic. A safe and pragmatic approach to service provisionReview Published on 2022-12-012023-07-06 Journal: Medicina [Category] COVID19(2023년), [키워드] coronavirus COVID-19 CTEV DDH Elective surgery fractures guidelines Paediatric orthopaedic Pathways SARS-CoV-2 Trauma. [DOI] 10.1016/j.surge.2021.08.004 PMC 바로가기 [Article Type] Review
Identification of the Hub Genes and the Signaling Pathways in Human iPSC-Cardiomyocytes Infected by SARS-CoV-2Article Published on 2022-12-012022-11-16 Journal: Biochemical Genetics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Analysis applied Bioinformatics analysis biological process Biomarker Brain caused component Cytoscape software database dataset DEGs differentially expressed gene direct infection down-regulated gene enrichment analysis function Gene Expression Omnibus gene expression profile Gene ontology Genes GEO GraphPad Prism software High-throughput sequencing hub genes Human Human iPSC-cardiomyocytes identification infected with SARS-CoV-2 intestine KEGG kidney Kyoto Ligand liver Lung injury mechanisms myocardial injury organ pathway Pathways PPI PPI network protein-protein interaction R software receptor Research respiratory respiratory symptom SARS-CoV-2 SARS-CoV-2. screened sequencing data signaling pathway single-stranded RNA virus statistical analysis statistically significant TNF signaling Type type I interferon up-regulated was obtained was performed website [DOI] 10.1007/s10528-022-10206-7 PMC 바로가기
Genetics of COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic reviewArticle Published on 2022-11-012022-11-16 Journal: Annals of Clinical and Translational Neurology [Category] 변종, [키워드] ACE affected Analysis association chemokine cohort study components conditions COVID-19 cytokine signaling Enzymes evolutionary relationship expression fatigue functional annotation Genetic genetic component Genetic variant highlight HLA-A HLA-C HLA-DQA1 HLA-DRB1 immune dysfunction Inflammation investigated Mental Ontology Pathogenesis Pathway analysis Pathways performed physical Protein Proteins receptor signaling significantly similarity Symptoms syndrome systematic review T cell activation TYK2 [DOI] 10.1002/acn3.51631 PMC 바로가기
IL-6 signalling biomarkers in hospitalised patients with moderate to severe SARS-CoV-2 infection in a single centre study in SwedenResearch article Published on 2022-11-012022-10-05 Journal: Cytokine [Category] SARS, 바이오마커, [키워드] addition analysed baseline Biomarker Biomarkers C-reactive protein (CRP Care classical correlated correlation COVID-19 COVID-19 disease severity COVID-19 pandemic CRP Cytokine/IL-6 defined demonstrated Epidemiology First wave glycoprotein group groups hospital Hospital admission hospitalised patient IL-6 IL-6 pathway IL-6 receptor immune immune response Infection Inflammation intensive care involved Level longitudinal cohort study marker moderate moderate-severe Mortality not differ pathogen pathway Pathways Patient patients with moderate plasma Potential difference Respiratory Support Result severe COVID-19 severe SARS-CoV-2 sgp130 significantly sIL-6R with COVID-19 [DOI] 10.1016/j.cyto.2022.156020 [Article Type] Research article
Promising SARS-CoV-2 main protease inhibitor ligand-binding modes evaluated using LB-PaCS-MD/FMOArticle Published on 2022-10-262022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] antiviral activity antiviral drugs atomic binding blind cascade cellular Clustering complex cytotoxicity docking evaluated exhibited flexible FMO inhibitor interact Interaction Ligand M pro mechanism molecular Pathways protease protein-ligand interactions provided residues SARS-CoV-2 SARS-CoV-2 main protease target protein the binding affinity the SARS-CoV-2 [DOI] 10.1038/s41598-022-22703-1 PMC 바로가기
Two Ligand-Binding Sites on SARS-CoV-2 Non-Structural Protein 1 Revealed by Fragment-Based X-ray ScreeningArticle Published on 2022-10-182022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] affinity Antiviral antiviral drug applicability assays atomic resolution caused consequence Consequences conserved coronavirus CoV COVID-19 cross-binding effects Degradation drug design effective Efficiency expression fragment-based X-ray screening functional Health Host host mRNA IFN infection rate inhibitor interferon ligands limitation MERS coronaviruses mortality rate N-terminal domain non-structural protein non-structural protein 1 outbreak pandemic Pathways Protein provide Replication respiratory Revealed Safe SARS-CoV-2 Screening Site starting point structure-based drug design. unique vaccination Vaccines variety virulence virus X-ray X-ray crystallography [DOI] 10.3390/ijms232012448 PMC 바로가기
Targeting SARS-CoV-2 Main Protease for Treatment of COVID-19: Covalent Inhibitors Structure-Activity Relationship Insights and Evolution PerspectivesArticle Published on 2022-10-132022-11-15 Journal: Journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] analysis analyzed antiviral drug catalytic category cysteine eight electrophilic enzyme example highlighting in silico in vitro in vivo inhibitor inhibitors insight involved mechanism Pathways protease protocols provided reactive relationship Replication reported SARS-CoV-2 Scientific community selective target targeting the SARS-CoV-2 virus without affecting [DOI] 10.1021/acs.jmedchem.2c01005 PMC 바로가기
Interplay between demographic, clinical and polygenic risk factors for severe COVID-19Article Published on 2022-10-132022-11-15 Journal: International Journal of Epidemiology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] 95% CI adjusted odds ratio Admission age antiviral response association co-morbidity conducted COVID-19 COVID-19 diagnosis Critical care death develop diagnosed with COVID-19 enrolment Epidemiology European Factor Factors General population genetic data genetic risk factor Genetic variant greater highest hospital Hospitalization identify IMPROVE individual interquartile range lowest median men morbidity obesity outcomes participant Pathway analysis Pathways Patient polygenic risk score polymorphism PRS reported risk risk factor risk prediction. severe COVID-19 single-nucleotide Smokers socio-demographic UK biobank was performed [DOI] 10.1093/ije/dyac137 PMC 바로가기
Effects of a Shift of the Signal Peptide Cleavage Site in Signal Peptide Variant on the Synthesis and Secretion of SARS-CoV-2 Spike ProteinArticle Published on 2022-10-082022-11-16 Journal: Molecules [Category] COVID19(2023년), SARS, 변종, [키워드] caused changed cleavage site COVID-19 COVID-19 pandemic demonstrated drug Effect evaluate the effect Host I13 Infection investigated mutant mutants Mutation N-terminal Pathways Protein RBD RBD protein SARS-CoV-2 SARS-CoV-2 spike protein secretion shift signal signal peptide signal peptide. significantly Site spike Spike protein synthesis the SARS-CoV-2 the signal peptide the spike protein treat wild type [DOI] 10.3390/molecules27196688 PMC 바로가기
Live and let die: signaling AKTivation and UPRegulation dynamics in SARS-CoVs infection and cancerArticle Published on 2022-10-032022-11-16 Journal: Cell Death & Disease [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, [키워드] acute respiratory syndrome AKT Cancer Cell Comorbidity coronavirus coronavirus disease COVID-19 de novo death deregulated drug Drug discovery Evidence feedback homeostasis homeostatic Infection Interaction maintain mechanism opposite pandemic pathogen pathway Pathways progression recent reduce regulate Regulation response responsible SARS-CoV SARS-CoV-2 SARS-COV-2 infection shown Signaling signaling cascade significantly survival therapeutic purposes Topic Treatment UPR viral infection viral infections [DOI] 10.1038/s41419-022-05250-5 PMC 바로가기