Physiologically Based Pharmacokinetic Modeling in Neonates: Current Status and Future PerspectivesReview Published on 2023-12-122024-09-05 Journal: Pharmaceutics [Category] update2024, [키워드] modeling and simulation PBPK preterm infants term infants [DOI] 10.3390/pharmaceutics15122765 PMC 바로가기 [Article Type] Review
Pharmacokinetics under the COVID-19 stormarticle Published on 2023-01-012024-09-02 Journal: British Journal of Clinical Pharmacology [Category] 대상포진, [키워드] ADME COVID-19 cytokine Drug-drug interactions PBPK PKPD [DOI] 10.1111/bcp.14668 PMC 바로가기 [Article Type] article
In vitro and in vivo evaluation of the main protease inhibitor FB2001 against SARS-CoV-2Article Published on 2022-12-012023-07-10 Journal: Antiviral Research [Category] COVID19(2023년), [키워드] Anti-SARS-CoV-2 in vivo FB2001 main protease PBPK SARS-CoV-2 SARS-CoV-2 variants [DOI] 10.1016/j.antiviral.2022.105450 PMC 바로가기
Pulmonary Delivery of Aerosolized Chloroquine and Hydroxychloroquine to Treat COVID-19: In Vitro Experimentation to Human Dosing PredictionsCOVID-19를 치료하기 위해 에어로졸 화 클로로퀸 및 하이드 록시 클로로 퀴인의 폐 전달 : 인간 투약 예측에 대한 시험 관내 실험Research Article Published on 2022-02-072022-09-10 Journal: The AAPS Journal [Category] 신약개발, [키워드] Abstract acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration aerosol Aerosols bronchial epithelial cell Cell cell viability characterized Chloroquine Clinical significance Concentration concentrations coronavirus COVID-19 delivery dose Dosing drug effective Efficacy electrical resistance epithelial cells evaluated exposure to Human humans Hydroxychloroquine in vitro inhalation Inhaled Local lung lysosomal oral administration PBPK pharmacokinetic pharmacokinetics pharmacological physicochemical property predicted prediction primary human bronchial epithelial cells pulmonary respiratory respiratory tract SARS-CoV-2 severe acute respiratory syndrome Coronavirus significant changes in supplementary material target tissue thermal these compound these compounds tissue Toxicity transepithelial electrical resistance treat viability [DOI] 10.1208/s12248-021-00666-x PMC 바로가기 [Article Type] Research Article
Design and tests of prospective property predictions for novel antimalarial 2-aminopropylaminoquinolones신규 항말라리아 2-아미노프로필아미노퀴놀론에 대한 잠재적 물성 예측의 설계 및 테스트Article Published on 2020-08-242024-08-26 Journal: Journal of Computer-Aided Molecular Design [Category] 말라리아, [키워드] ADME antimalarial dihydroorotate dehydrogenase drug design PBPK QSAR [DOI] 10.1007/s10822-020-00333-x PMC 바로가기 [Article Type] Article