Pulmonary delivery of favipiravir inhalation solution for COVID-19 treatment: in vitro characterization, stability, in vitro cytotoxicity, and antiviral activity using real time cell analysisArticle Published on 2022-12-012022-11-15 Journal: Drug Delivery [Category] COVID19(2023년), SARS, 치료제, [키워드] addition administration Analysis Antiviral antiviral activity Calu-3 Cell characterized Concentration COVID-19 cytotoxicity Favipiravir in vitro indicated Influenza virus Inhaled inhaled formulation inhibitor investigated lung lung epithelial cell lung tissue Lungs media Patient patients with COVID-19 PBS phosphate buffer profile pulmonary RdRP real time required respiratory RNA-dependent RNA polymerase SARS-CoV-2 stability target Toxicity treat Treatment VERO-E6 viability were infected [DOI] 10.1080/10717544.2022.2118398 PMC 바로가기
Novel approach based on GQD-PHB as anchoring platform for the development of SARS-CoV-2 electrochemical immunosensorArticle Published on 2022-11-012022-11-15 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] addition analyzed antibodies antibody approach Blood carbon Carbon nanomaterial Concentration conditions coronavirus spike protein decrease develop domain Dot DPV Electrochemical devices Fever functional Graphene human serum Immunosensors construction. Interaction investigated matrix effect Modification novel PBS performed platform probe Protein provided pulse quantum RBD SARS-CoV-2 selective SEM serum shown was tested was used [DOI] 10.1016/j.aca.2022.340442 PMC 바로가기
Evaluation of the impact of pre-analytical conditions on sample stability for the detection of SARS-CoV-2 RNAArticle Published on 2022-11-012022-11-15 Journal: Journal of virological methods [Category] SARS, 치료기술, 치료제, [키워드] collected Community condition conditions cycle threshold Demand Diagnosis diagnostics False negative increase in independent Laboratory MOST PBS postal service provide RNA RNA extraction RT-qPCR Sample Sample stability. SARS-CoV-2 SARS-CoV-2 E gene SARS-CoV-2 RNA sensitivity stability Swab temperature tested Transport media transported Variation Viral load VTM [DOI] 10.1016/j.jviromet.2022.114607 PMC 바로가기
Real-time COVID-19 detection via graphite oxide-based field-effect transistor biosensors decorated with Pt/Pd nanoparticlesArticle Published on 2022-10-282022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] antibody Antigen Characteristics COVID-19 COVID-19 diagnosis COVID-19 virus Critical early diagnosis graphite Infectious disease limit of detection maintain PBS phosphate-buffered saline public health resulting SARS-CoV-2 spike sensitivity specific antibody specific treatment specificity Spike protein Spread thermal was used with COVID-19 [DOI] 10.1038/s41598-022-22249-2 PMC 바로가기
Efficacy of COVID-HIGIV in animal models of SARS-CoV-2 infectionArticle Published on 2022-10-102022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 비임상, 진단, [키워드] acute respiratory syndrome animal model anti-SARS-CoV-2 baseline Body weight loss caused China controls convalescent plasma coronavirus COVID-19 COVID-19 vaccines deaths Efficacy evaluated faster hamster hamsters Hospitalization Human Immunoglobulin intravenous Lung inflammation Lung pathology Lungs mice monoclonal antibody mouse model ongoing trial PBS plasma reduced SARS-CoV-2 SARS-COV-2 infection significantly Spread Support therapeutic option treated Treatment Viral load virus was reduced worldwide pandemic [DOI] 10.1038/s41598-022-21223-2 PMC 바로가기
Antiviral effect of multipurpose contact lens disinfecting solutions against coronavirusArticle Published on 2022-10-012022-11-15 Journal: Contact lens & anterior eye : the journal of the British Contact Lens [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] Ammonium Antiviral antiviral activity Concentration conducted Contact Contact len Contact lens disinfection coronavirus Detection limit evaluate Final FIVE hydrogen hydrogen peroxide incubated Iodine kill log mouse hepatitis virus negative control oxidative PBS phosphate buffer plaque forming unit quantified quaternary ammonium reduced reduction regimen SARS-CoV-2 significantly temperature Test treated Treatment virus [DOI] 10.1016/j.clae.2021.101513 PMC 바로가기
A new-type HOCl-activatable fluorescent probe and its applications in water environment and biosystems새로운 유형의 HOCl 활성화 가능한 형광 프로브 및 물 환경 및 생물 시스템에서의 응용Article Published on 2022-09-152022-09-11 Journal: The Science of the total environment [Category] 치료기술, 치료제, [키워드] Accuracy Affect aggregate assistance Biotin biotinylated Cancer cancer cell Cancer cells cancer diagnosis Cell cells chlorine Concentration Consumption contribute convenience Corona COVID-19 Early Cancer expected Fluorescence fluorescent Fluorescent probe Health HOCl human body hypochlorite hypochlorous acid inflammatory disease Inflammatory diseases introduced kill membrane outbreak overexpressed oxygen PBS Precision probe reactive oxygen specy receptor ROS significant increase sodium sodium hypochlorite Spread Virus Disease viruses water Water samples. while [DOI] 10.1016/j.scitotenv.2022.156164 PMC 바로가기 [Article Type] Article
Transient production of receptor-binding domain of SARS-CoV-2 in Nicotiana benthamiana plants induces specific antibodies in immunized miceNicotiana benthamiana 식물에서 SARS-CoV-2의 수용체 결합 도메인의 일시적인 생산은 면역된 마우스에서 특정 항체를 유도합니다Article Published on 2022-07-012022-09-12 Journal: Molecular biology reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] affected antibodies antigen expression benthamiana caused Cell coronavirus COVID-19 pandemic diagnostic system domain drug evaluate Host identity immune immunization immunized mice immunogenicity induce Interaction mice N. benthamiana Nicotiana benthamiana PBS plant platform produced Protein RBD RBD protein RBDr receptor ACE2 SARS-CoV-2 SARS-CoV-2 virus Scientific community specific antibody Spike protein spread of COVID-19 Support the receptor-binding domain the SARS-CoV-2 Transient treated vaccine candidates Vaccines viral surface [DOI] 10.1007/s11033-022-07402-4 PMC 바로가기 [Article Type] Article
Oral Immunization of Mice with Cell Extracts from Recombinant Lactococcus lactis Expressing SARS-CoV-2 Spike ProteinSARS-CoV-2 스파이크 단백질을 발현하는 재조합 락토코커스 락티스의 세포 추출물을 사용한 마우스의 경구 면역Article Published on 2022-04-232022-09-11 Journal: Current microbiology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Administered analyzed Antigen antigen-specific antibody Bacteria Beta Cell changes in coronavirus coronavirus disease coronavirus disease-2019 COVID-19 develop domain expressing Extract fecal Gut gut microbiome IgA level immunization immunized mice induce Intracellular intramuscular lactic acid Lactococcus less mass vaccination mice Microbiome oral Oral vaccine pandemic PBS present profile progressed Protein RBD recombinant respiratory S1 subunit SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 spike secretion separated serum IgG severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 similarity specific antibodies spike Spread strain Treatment two group two groups vaccination Vaccine Vaccines Viral [DOI] 10.1007/s00284-022-02866-w PMC 바로가기 [Article Type] Article
Systematic evaluating and modeling of SARS-CoV-2 UVC disinfectionSARS-CoV-2 UVC 소독의 체계적인 평가 및 모델링Article Published on 2022-04-072022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] absorbance aerosol Aerosols amino acids attenuation buffer cell culture medium change COVID-19 Critical Culture culture medium determine dosage dose effective Effectiveness evaluate exceeded exposure to FBS global pandemic greater highlight highlighting inverse correlation lowest measure media medium N95 mask N95 masks niacinamide pathogen Pathogens PBS Radiation reducing reduction SARS-CoV-2 SARS-CoV-2 susceptibility Stratum corneum susceptibility UV light viral infectivity Viral transmission virus viruses vitamins wavelength wavelengths [DOI] 10.1038/s41598-022-09930-2 PMC 바로가기 [Article Type] Article