New Tetramic Acid Derivatives From the Deep-Sea-Derived Fungus Penicillium sp. SCSIO06868 With SARS-CoV-2 M pro Inhibitory Activity EvaluationMicrobiology Published on 2021-09-272022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] Penicillium sp. acid activity acute respiratory syndrome Analysis Antibacterial Antiviral antiviral activity Compound coronavirus coronavirus disease Culture deep-sea-derived fungus derivative ECD eight electrospray ionization exhibited fungus High-resolution inhibitory activity inhibitory concentration M pro New NMR nuclear optical pandemic Penicillium protease reported responsible SARS-CoV-2 secondary metabolites selective Staphylococcus aureus Structure X-ray crystallography [DOI] 10.3389/fmicb.2021.730807 PMC 바로가기 [Article Type] Microbiology
Bioguided Isolation of Cyclopenin Analogues as Potential SARS-CoV-2 M pro Inhibitors from Penicillium citrinum TDPEF34Article Published on 2021-09-152022-10-28 Journal: Biomolecules [Category] COVID-19, SARS, [키워드] analogue analysed anti-SARS-CoV-2 binding comparable Compound Critical cyclopenin docking drug candidates Drug discovery drug-likeness effective enzyme fungal H-bonding hydrophobic interactions identify in silico in vitro in vivo Infection information inhibit inhibiting inhibitors inhibitory activity Isolation M pro MPro molecular molecular dynamic simulations Mutation natural pandemic Penicillium Penicillium citrinum positive control Potential predicted protease reduce SARS-CoV-2 SARS-CoV-2 virus screened severity these compound Vaccine virulence virus [DOI] 10.3390/biom11091366 PMC 바로가기 [Article Type] Article
Repurposing proteases: An in-silico analysis of the binding potential of extracellular fungal proteases with selected viral proteinsResearch article Published on 2021-09-012022-10-05 Journal: Bioresource Technology Reports [Category] 신약개발, [키워드] Analysis Antiviral binding binding energy COVID degrade docking drugs enzyme Enzymes Extracellular fungal identify in-silico infectious agents microbial Penicillium protease Protein repurposing resource selected tap the SARS-CoV-2 virus therapeutic therapeutic agent Viral protein viral spike [DOI] 10.1016/j.biteb.2021.100756 [Article Type] Research article
Gut mycobiota alterations in patients with COVID-19 and H1N1 infections and their associations with clinical featuresArticle Published on 2021-04-132022-10-04 Journal: Communications Biology [Category] MERS, SARS, 바이오마커, 신종인플루엔자, [키워드] alteration analysed Aspergillus Aspergillus niger association Bacterial C-reactive protein Candida characterized clinical feature correlated COVID-19 COVID-19 patient COVID-19 patients CRP diarrhoea discharged Dysbiosis Effects fungal Fungal ecology fungi Gut H1N1 H1N1 infection had no HCs healthcare healthy control healthy controls IMPROVE Infectious diseases microbe microbiota Mild occur Patient patients patients with COVID-19 Penicillium positively correlated procalcitonin profile Sequencing severe symptom spacer the patient transcribed [DOI] 10.1038/s42003-021-02036-x PMC 바로가기 [Article Type] Article