A peptide array pipeline for the development of Spike-ACE2 interaction inhibitorsArticle Published on 2022-12-012023-07-10 Journal: Peptides [Category] COVID19(2023년), [키워드] ACE2 peptide array Peptide inhibitor spike [DOI] 10.1016/j.peptides.2022.170898 PMC 바로가기
A Syntenin Inhibitor Blocks Endosomal Entry of SARS-CoV-2 and a Panel of RNA VirusesArticle Published on 2022-10-062022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome Antiviral antivirals bind block cellular membrane Chikungunya CHIKV coronavirus dependent on develop domain endosomal endosomal entry Factor flavivirus Host HPV Infection inhibit inhibitor Interaction Panel peptide Peptide inhibitor Protein protein trafficking provide reduced regulate replicate RNA RNA viruses SARS-CoV-2 shown syntenin. target targeting virus [DOI] 10.3390/v14102202 PMC 바로가기
Novel Engineered SARS-CoV-2 HR1 Trimer Exhibits Improved Potency and Broad-Spectrum Activity against SARS-CoV-2 and Its Variants신규 설계된 SARS-CoV-2 HR1 삼량체, SARS-CoV-2 및 그 변이체에 대해 향상된 효능 및 광범위한 활성을 나타냄Article Published on 2022-07-132022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] activities activity adopted affinity antibodies binding affinity C terminus caused cell-cell fusion develop domain effective Effectiveness foldon foundation fusing fusion fusion inhibitor global public health HR1 HR1 domain Improved increased the risk information inhibit inhibit SARS-CoV-2 inhibitor inhibitors inhibitory inhibitory activity limit MERS MERS-CoV MERS-CoV pseudoviruses motif much higher Multiple NAbs Neutralizing antibodies neutralizing antibody novel pandemic of COVID-19 peptide Peptide inhibitor Peptide Inhibitors peptides potency provide pseudoviruses reported S protein SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants shown significantly Spread the S protein the SARS-CoV-2 theory treating SARS-CoV-2 infection trimer trimeric Vaccine variants viral infection viral S protein viral variant Viral variants VOCs [DOI] 10.1128/jvi.00681-22 PMC 바로가기 [Article Type] Article
Inhibition of SARS-CoV-2 pathogenesis by potent peptides designed by the mutation of ACE2 binding regionACE2 결합 영역의 돌연변이에 의해 설계된 강력한 펩티드에 의한 SARS-CoV-2 발병 억제Article Published on 2022-07-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding allergenicity angiotensin Angiotensin-converting enzyme antiviral peptide binding energy complex Computational approaches COVID-19 COVID-19 treatment criteria deaths determined by Diagnosis docked domain Drug development effective inhibitor entry inhibitors Final host receptor identify information inhibition inhibitor inhibitory action initial Interaction mechanism molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations Mutation OSPREY outbreak pandemic peptide Peptide design Peptide inhibitor Peptide Inhibitors peptides provided RBD RBD binding RBD residue RBD residues RBD-ACE2 Receptor-binding domain residue residues SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 pathogenesis screened Spike protein spread of COVID-19 targeting Template the RBD Therapeutics Treatment vaccination variant Viral entry inhibitors. viral infection virus was determined [DOI] 10.1016/j.compbiomed.2022.105625 PMC 바로가기 [Article Type] Article
Targeting SARS-CoV-2 Proteases for COVID-19 Antiviral DevelopmentChemistry Published on 2022-02-032022-10-31 Journal: Frontiers in Chemistry [Category] COVID-19, [키워드] 3CLpro acute respiratory syndrome adopted antiviral drug antivirals approved biochemical assay candidate cells coronavirus COVID-19 Critical curtail death development Disease progression drug effective Evolution facilitate food highly pathogenic hospitalized patients Host IMPROVE Infection inhibition inhibitor inhibitory effect innate immune responses main protease maturation moderate MPro Occurrence Papain-like protease Peptide inhibitor PLPro Potential Prophylactic protease protease inhibitors Research SARS-CoV-2 SARS-CoV-2 protease sustained targeting targets therapeutic efficacy Treatment vaccination rate Vaccine Viral protein viral replication viral variant virus [DOI] 10.3389/fchem.2021.819165 PMC 바로가기 [Article Type] Chemistry
Inhibition of Viral Membrane Fusion by Peptides and Approaches to Peptide DesignReview Published on 2021-12-092022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] 6-helix bundle approach binding CD4 cellular plasma membrane coiled coil computation methods computational method conformational change database filoviruses fusion fusion protein gp120 Hepatitis herpesvirus HIV-1 Infection Influenza Influenza virus inhibit inhibition interfere involved membrane membrane fusion MERS peptide Peptide design Peptide inhibitor Protein receptor receptors SARS coronaviruses SARS-CoV-2 sequence Spike protein surface protein synthetic undergo viral envelope protein virus virus entry viruses [DOI] 10.3390/pathogens10121599 PMC 바로가기 [Article Type] Review
Inhibition of the RNA-dependent RNA Polymerase of the SARS-CoV-2 by Short Peptide Inhibitors짧은 펩티드 억제제에 의한 SARS-CoV-2의 RNA 의존성 RNA 중합효소 억제Article Published on 2021-12-012022-09-11 Journal: European journal of pharmaceutical sciences : offi [Category] SARS, 치료제, [키워드] activities activity antiviral agent Antiviral agents approach Arg2 binding site comparison complexes COVID-19 COVID-19 patient detrimental docking Docking studies drug drugs early recovery help inhibiting inhibition inhibitor inhibitors insertion insertion site molecular docking NTP nucleotide nucleotides patients peptide Peptide inhibitor Peptide Inhibitors peptides proliferation RdRP Remdesivir Replication RNA RNA-dependent RNA polymerase SARS-CoV-2 synthesis the SARS-CoV-2 viral genome Viral load viral loads [DOI] 10.1016/j.ejps.2021.106012 PMC 바로가기 [Article Type] Article
Integrin activation is an essential component of SARS-CoV-2 infection인테그린 활성화는 SARS-COV-2 감염의 필수 구성 요소입니다Article Published on 2021-10-142022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 Activation angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antagonist basal state bind binding Cell adhesion Cell Biology cell entry confocal microscopy cytoplasmic tail Diseases downstream engage Engagement ENhance enzyme expresse extension flow cytometry inactive induce Infection Infectious diseases inhibit inhibited integrin Integrins ligands macromolecular mechanism membrane motif occur Particle peptide Peptide inhibitor Protein receptors rhodamine rhodamine B S protein SARS-CoV-2 SARS-COV-2 infection Signaling subunit viral infection [DOI] 10.1038/s41598-021-99893-7 PMC 바로가기 [Article Type] Article
Discovery of SARS-CoV-2 M pro peptide inhibitors from modelling substrate and ligand binding †Chemistry Published on 2021-09-062022-10-31 Journal: Chemical Science [Category] COVID-19, [키워드] analysed Analysis automated bind binding building cleavage site cleavage sites COVID Critical docked docking drug design drug target drugs effective highlight inhibit inhibitor inhibitors initial Interaction Ligand ligands M pro maturation molecular molecular feature N-terminal peptide Peptide inhibitor Peptide Inhibitors peptides plasticity Predictive protease QM/MM SARS-CoV-2 substrates Variation [DOI] 10.1039/d1sc03628a PMC 바로가기 [Article Type] Chemistry
Structure-based drug design of an inhibitor of the SARS-CoV-2 (COVID-19) main protease using free software: A tutorial for students and scientistsResearch article Published on 2021-06-012022-10-05 Journal: European journal of medicinal chemistry [Category] SARS, 신약개발, [키워드] AutoDock AutoDock vina coronavirus COVID-19 disseminate drug drug candidate drug design experimental validation help homologous information inhibitor Interaction Main protease (Mpro) inhibitor modify molecular docking Molecular modeling tutorial MPro pandemic Pandemics peptide Peptide inhibitor protease protocol provide SARS Coronavirus SARS-CoV SARS-CoV-2 SARS-CoV-2 Mpro structure-based design Structure-based drug design (SBDD) structures the SARS-CoV-2 UCSF Chimera X-ray X-ray crystallographic structure [DOI] 10.1016/j.ejmech.2021.113390 [Article Type] Research article