peripheral blood lymphocyte – Communicable Diseases Research

DNA damage in peripheral blood lymphocytes of severely ill COVID-19 patients in relation to inflammatory markers and parameters of hemostasis

Article

Published on 2022-10-262022-11-15
Journal: Mutagenesis [Category] 바이오마커, 치료제,

Kinetics and Persistence of the Cellular and Humoral Immune Responses to BNT162b2 mRNA Vaccine in SARS-CoV-2-Naive and -Experienced Subjects: Impact of Booster Dose and Breakthrough Infections

SARS-CoV-2-나이브 및 -경험 대상자에서 BNT162b2 mRNA 백신에 대한 세포 및 체액 면역 반응의 동역학 및 지속성: 추가 용량 및 돌발 감염의 영향

Article

Published on 2022-05-312022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법,

[키워드] administration age analyzed Anti-nucleocapsid antibodies anti-SARS-CoV-2 anti-spike antibodies anti-spike antibody antibodies antibody association Belgium benefit blood sample Blood samples blood sampling BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine booster booster dose booster doses breakthrough infections cell-mediated immune response cellular cellular and humoral immune response Cellular immune response cellular immune responses collected COVID-19 COVID-19 vaccine DiaSorin dose Elecsy enrolled evaluated greater HCW HCWs Healthcare system healthcare worker Healthcare workers help Human humoral Humoral and cellular immune responses humoral immune response Humoral response IFN-γ IgG immune protection immune response immune responses immunization immunogenicity Impact implication increase in individual level individuals Infection initial Kinetics LIAISON Lymphocytes management mandatory mRNA vaccination mRNA vaccine naïve naïve individuals natural infection Neutralization assay neutralization capacity Neutralizing antibodies pandemic participant Participants Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes persistence Prevent Prospective Study Qiagen QuantiFERON quantified reduce regimen response SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination second dose secretion severe COVID-19 significantly higher tested the SARS-CoV-2 triggering understanding university vaccination vaccine dose variant Vero E6 was performed
[DOI] 10.3389/fimmu.2022.863554 PMC 바로가기 [Article Type] Article

Integrated hepatic single-cell RNA sequencing and untargeted metabolomics reveals the immune and metabolic modulation of Qing-Fei-Pai-Du decoction in mice with coronavirus-induced pneumonia

통합 된 간 단일 세포 RNA 시퀀싱 및 표적화되지 않은 대사체는 코로나 바이러스-유도 폐렴과 마우스에서 Qing-Fei-Pai-Du 달인의 면역 및 대사 조절을 보여준다.

Article

Published on 2022-03-012022-08-31
Journal: Phytomedicine : international journal of phytother [Category] 유전자 메커니즘, 치료제,

[키워드] alteration Analysis attenuate B cells BALB/c mice best CD4 CD8 clinically Cold Cold-damp environment Combination Control control group coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus pneumonia COVID-19 patients Cytokines damp environment disease disease-associated exposure to Gene Expression HCoV HCoV-229E human coronavirus IFN-γ IL-6 immune immune function Immunity immunological IMPROVE indicated infecting Infection Inflammation Inflammatory cytokine Inflammatory cytokines knowledge Liver injury liver tissue Lymphocytes mechanism mechanism of action metabolic function metabolism metabolomics mice Model modulate modulation mouse model Mouse models performed Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes Pneumonia profile purine Qing-Fei-Pai-Du decoction reduce regulated Regulatory reveal RNA RNA sequencing significantly significantly increased Single-cell RNA sequencing status T cells TCM therapy TNF-α transcriptional treat treated Treatment Untargeted metabolomics
[DOI] 10.1016/j.phymed.2021.153922 PMC 바로가기 [Article Type] Article

Are angiotensin converting enzyme (ACE1/ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A single-center cohort study

안지오텐신 전환 효소(ACE1/ACE2) 유전자 변이가 COVID-19 폐렴의 임상 중증도와 관련이 있습니까? 단일 센터 코호트 연구

Article

Published on 2022-02-012022-09-11
Journal: Anatolian journal of cardiology [Category] COVID19(2023년), SARS, 변종, 치료기술,

[키워드] abnormality ACE ACE gene ACE1 ACE1 gene ACE1/ACE2 ACE2 ACE2 gene Admission age allele Analysis angiotensin angiotensin converting enzyme automated Bioinformatics analysis Clinical characteristics Clinical severity Cohort cohort study coronavirus disease Coronavirus disease 2019 COVID-19 determine disease severity DNA domain DSP enzyme exon 1 frequencies Frequency functional Genetic Genomic DNA Genotype group I/D polymorphism ICU independent predictor independent predictors intensive care intensive care unit investigated knowledge no effect non-ICU Older age other variant pandemic Patient patients hospitalized Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes Pneumonia polymorphism Polymorphisms purified radiologic recent Sanger sequencing Science Sequencing analysis severe disease single-center statistical analysis Statistical Package variant was performed was used
[DOI] 10.5152/AnatolJCardiol.2021.502 PMC 바로가기 [Article Type] Article

T cell counts and IL-6 concentration in blood of North African COVID-19 patients are two independent prognostic factors for severe disease and death

북아프리카 COVID-19 환자의 혈액 내 T 세포 수와 IL-6 농도는 심각한 질병 및 사망에 대한 두 가지 독립적인 예후 인자입니다

Article

Published on 2022-01-012022-09-11
Journal: Journal of leukocyte biology [Category] 바이오마커,

[키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition African Analysis B cells Blood CD4+ T cells CD8+ T cell CD8+ T cells characteristic clinician Concentration coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 patients cutoff value cytokine cytokine level cytokine levels Cytokines death death group develop disease flow cytometry healthy control healthy controls help high risk IL-10 IL-6 immune parameter immune system independent investigated lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes Mild Mortality multivariate logistic regression multivariate logistic regression analysis natural killer cell Natural killer cells North outcome parameter pathology Patient patients percentage percentages performed Peripheral blood peripheral blood lymphocyte predict Prognosis Prognostic factor receiver operating characteristic respiratory risk ROC ROC curves SARS-CoV2 severe acute respiratory syndrome Coronavirus severe cases severe disease severity severity of illness significant difference significant differences significantly higher statistical difference statistical differences subset survival T cell T cells Th17 Th2 the disease the patient threshold Total two group two groups
[DOI] 10.1002/JLB.4COVA1020-703R PMC 바로가기 [Article Type] Article

Analysis of Lymphocyte Subpopulations and Cytokines in COVID-19-Associated Pneumonia and Community-Acquired Pneumonia

COVID-19 관련 폐렴 및 지역사회 획득 폐렴의 림프구 하위집단 및 사이토카인 분석

Research Article

Published on 2021-06-122022-09-12
Journal: Journal of Immunology Research [Category] MERS, SARS, 진단,

[키워드] 2019 novel coronavirus addition calculated caused CD16 CD19 CD3 CD4 CD56 CD8 Clinical outcome community-acquired pneumonia COVID-19 COVID-19 diagnosis COVID-19 patient cytokine Cytokines disease severity identify IFN independent independent predictor independent predictors Logistic regression lymphocyte lymphocyte subpopulation Lymphocyte subset Lymphocyte subsets lymphopenia Novel coronavirus outbreak Patient patients patients with COVID-19 Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes predict predictor Result SARS-CoV-2 SARS-COV-2 infection severity significantly subset the disease TNF- α
[DOI] 10.1155/2021/6657894 PMC 바로가기 [Article Type] Research Article

Circulating Adaptive Immune Cells Expressing the Gut Homing Marker α4β7 Integrin Are Decreased in COVID-19

Gut Homing Marker α4β7 Integrin을 발현하는 순환 적응 면역 세포는 COVID-19에서 감소합니다

Immunology

Published on 2021-04-202022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive B cell cause characterized circulating contribute convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 decrease Decreased epithelial cells expressing expression flow cytometry Frequency Gastrointestinal symptom gastrointestinal symptoms Gut gut homing healthy control healthy controls homing IgA IgA-expressing Immune cell immune cells immune responses immune system integrin Integrins intestinal intestinal epithelial cell intestinal epithelial cells Lymphocytes Manifestations marker memory T Patient Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes priming recruited respiratory Result SARS-CoV-2 SARS-COV-2 infection Symptom systemic immune response systemic immune responses T cell trafficking target these cell These cells tissue virus was reduced while wide range of symptoms
[DOI] 10.3389/fimmu.2021.639329 PMC 바로가기 [Article Type] Immunology

Impaired Cellular Immunity to SARS-CoV-2 in Severe COVID-19 Patients

중증 COVID-19 환자의 SARS-CoV-2에 대한 세포 면역 손상

Immunology

Published on 2021-02-022022-09-12
Journal: Frontiers in Immunology [Category] MERS, 진단,

[키워드] acute infection acute phase acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome Adaptive immune response Adaptive immunity antibody Antibody Response ARDS CD4 CD8 cellular cellular immunity convalescent individual coronavirus COVID-19 COVID-19 patient develop exhibited expression healthy controls Hospitalization humoral immune responses IFNγ Impaired individual infection rate interferon gamma MOST mounted Neutralization antibody Neutralizing antibodies NK cell pandemic percentage Peripheral blood peripheral blood lymphocyte producing reduced responses SARS-CoV-2 severe COVID-19 patient Severe patient severe patients shown significantly Spread Symptoms syndrome T cell T cells Viral proteins virus
[DOI] 10.3389/fimmu.2021.603563 PMC 바로가기 [Article Type] Immunology

Shorter telomere lengths in patients with severe COVID-19 disease

중증 코로나19 환자의 텔로미어 길이 감소

Research Paper

Published on 2021-01-152022-09-10
Journal: Aging (Albany NY) [Category] 유전자 메커니즘,

[키워드] age aging Cell cell types chromosome contribute COVID-19 COVID-19 patient disease higher risk highest impair incidence increase individual infect limit Lymphocytes maintain manifestation mechanism molecular Mortality older patient older patients Pathologies pathway Patient Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes Protective regeneration regenerative SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus severe COVID-19 severe COVID-19 disease severe manifestations of COVID-19 severity severity of COVID-19 Structure telomere telomeres the disease tissue tissue homeostasis tissues Trigger
[DOI] 10.18632/aging.202463 PMC 바로가기 [Article Type] Research Paper

The changes of the peripheral CD4+ lymphocytes and inflammatory cytokines in Patients with COVID-19

Research Article

Published on 2020-09-252022-10-28
Journal: PLoS ONE [Category] COVID-19, MERS, SARS,

[키워드] calculated CD4+ CD4+ T lymphocyte change changes in correlated decrease disease elevated group IL-6 Inflammatory cytokine lymphocyte lymphocytopenia manifested patients with COVID-19 peripheral blood lymphocyte severity of COVID-19 subtype TNF-α with COVID-19
[DOI] 10.1371/journal.pone.0239532 PMC 바로가기 [Article Type] Research Article