peripheral blood lymphocytes – Communicable Diseases Research

Kinetics and Persistence of the Cellular and Humoral Immune Responses to BNT162b2 mRNA Vaccine in SARS-CoV-2-Naive and -Experienced Subjects: Impact of Booster Dose and Breakthrough Infections

SARS-CoV-2-나이브 및 -경험 대상자에서 BNT162b2 mRNA 백신에 대한 세포 및 체액 면역 반응의 동역학 및 지속성: 추가 용량 및 돌발 감염의 영향

Article

Published on 2022-05-312022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법,

Integrated hepatic single-cell RNA sequencing and untargeted metabolomics reveals the immune and metabolic modulation of Qing-Fei-Pai-Du decoction in mice with coronavirus-induced pneumonia

통합 된 간 단일 세포 RNA 시퀀싱 및 표적화되지 않은 대사체는 코로나 바이러스-유도 폐렴과 마우스에서 Qing-Fei-Pai-Du 달인의 면역 및 대사 조절을 보여준다.

Article

Published on 2022-03-012022-08-31
Journal: Phytomedicine : international journal of phytother [Category] 유전자 메커니즘, 치료제,

[키워드] alteration Analysis attenuate B cells BALB/c mice best CD4 CD8 clinically Cold Cold-damp environment Combination Control control group coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus pneumonia COVID-19 patients Cytokines damp environment disease disease-associated exposure to Gene Expression HCoV HCoV-229E human coronavirus IFN-γ IL-6 immune immune function Immunity immunological IMPROVE indicated infecting Infection Inflammation Inflammatory cytokine Inflammatory cytokines knowledge Liver injury liver tissue Lymphocytes mechanism mechanism of action metabolic function metabolism metabolomics mice Model modulate modulation mouse model Mouse models performed Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes Pneumonia profile purine Qing-Fei-Pai-Du decoction reduce regulated Regulatory reveal RNA RNA sequencing significantly significantly increased Single-cell RNA sequencing status T cells TCM therapy TNF-α transcriptional treat treated Treatment Untargeted metabolomics
[DOI] 10.1016/j.phymed.2021.153922 PMC 바로가기 [Article Type] Article

Are angiotensin converting enzyme (ACE1/ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A single-center cohort study

안지오텐신 전환 효소(ACE1/ACE2) 유전자 변이가 COVID-19 폐렴의 임상 중증도와 관련이 있습니까? 단일 센터 코호트 연구

Article

Published on 2022-02-012022-09-11
Journal: Anatolian journal of cardiology [Category] COVID19(2023년), SARS, 변종, 치료기술,

[키워드] abnormality ACE ACE gene ACE1 ACE1 gene ACE1/ACE2 ACE2 ACE2 gene Admission age allele Analysis angiotensin angiotensin converting enzyme automated Bioinformatics analysis Clinical characteristics Clinical severity Cohort cohort study coronavirus disease Coronavirus disease 2019 COVID-19 determine disease severity DNA domain DSP enzyme exon 1 frequencies Frequency functional Genetic Genomic DNA Genotype group I/D polymorphism ICU independent predictor independent predictors intensive care intensive care unit investigated knowledge no effect non-ICU Older age other variant pandemic Patient patients hospitalized Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes Pneumonia polymorphism Polymorphisms purified radiologic recent Sanger sequencing Science Sequencing analysis severe disease single-center statistical analysis Statistical Package variant was performed was used
[DOI] 10.5152/AnatolJCardiol.2021.502 PMC 바로가기 [Article Type] Article

Analysis of Lymphocyte Subpopulations and Cytokines in COVID-19-Associated Pneumonia and Community-Acquired Pneumonia

COVID-19 관련 폐렴 및 지역사회 획득 폐렴의 림프구 하위집단 및 사이토카인 분석

Research Article

Published on 2021-06-122022-09-12
Journal: Journal of Immunology Research [Category] MERS, SARS, 진단,

[키워드] 2019 novel coronavirus addition calculated caused CD16 CD19 CD3 CD4 CD56 CD8 Clinical outcome community-acquired pneumonia COVID-19 COVID-19 diagnosis COVID-19 patient cytokine Cytokines disease severity identify IFN independent independent predictor independent predictors Logistic regression lymphocyte lymphocyte subpopulation Lymphocyte subset Lymphocyte subsets lymphopenia Novel coronavirus outbreak Patient patients patients with COVID-19 Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes predict predictor Result SARS-CoV-2 SARS-COV-2 infection severity significantly subset the disease TNF- α
[DOI] 10.1155/2021/6657894 PMC 바로가기 [Article Type] Research Article

Circulating Adaptive Immune Cells Expressing the Gut Homing Marker α4β7 Integrin Are Decreased in COVID-19

Gut Homing Marker α4β7 Integrin을 발현하는 순환 적응 면역 세포는 COVID-19에서 감소합니다

Immunology

Published on 2021-04-202022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive B cell cause characterized circulating contribute convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 decrease Decreased epithelial cells expressing expression flow cytometry Frequency Gastrointestinal symptom gastrointestinal symptoms Gut gut homing healthy control healthy controls homing IgA IgA-expressing Immune cell immune cells immune responses immune system integrin Integrins intestinal intestinal epithelial cell intestinal epithelial cells Lymphocytes Manifestations marker memory T Patient Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes priming recruited respiratory Result SARS-CoV-2 SARS-COV-2 infection Symptom systemic immune response systemic immune responses T cell trafficking target these cell These cells tissue virus was reduced while wide range of symptoms
[DOI] 10.3389/fimmu.2021.639329 PMC 바로가기 [Article Type] Immunology

Shorter telomere lengths in patients with severe COVID-19 disease

중증 코로나19 환자의 텔로미어 길이 감소

Research Paper

Published on 2021-01-152022-09-10
Journal: Aging (Albany NY) [Category] 유전자 메커니즘,

[키워드] age aging Cell cell types chromosome contribute COVID-19 COVID-19 patient disease higher risk highest impair incidence increase individual infect limit Lymphocytes maintain manifestation mechanism molecular Mortality older patient older patients Pathologies pathway Patient Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes Protective regeneration regenerative SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus severe COVID-19 severe COVID-19 disease severe manifestations of COVID-19 severity severity of COVID-19 Structure telomere telomeres the disease tissue tissue homeostasis tissues Trigger
[DOI] 10.18632/aging.202463 PMC 바로가기 [Article Type] Research Paper

Unique immunological profile in patients with COVID-19

COVID-19 환자의 독특한 면역 프로필

Clinical Trial

Published on 2020-10-152022-08-13
Journal: Cellular and Molecular Immunology [Category] MERS, SARS, 바이오마커, 임상, 치료제,

[키워드] (PD-1 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adaptive Analysis CD56 CD57 CD69 CD8 Cell contraction Coronavirus-2 COVID-19 COVID-19 patient Cytokines Deceased disease distribution driven by effective expansion expression FcεRIγ Frequency healthy subject healthy subjects help host immunity IL-1β IL-6 IL-8 IL6 immature immune response immune responses Immunoglobulin immunological profile Increased Infection Inflammatory cytokine Inflammatory cytokines interferon Interleukins lectin Lymphocytes monocyte Monocytes Monocytes and macrophages mucin natural killer NK cell NK cells NKG2D outcome overexpressed Patient patients with COVID-19 PD-1 performed Peripheral blood peripheral blood lymphocytes positive cell positive cells programmed cell death programmed cell death protein proportion Protein reduced respiratory restoration SARS-CoV-2 SARS-COV-2 infection secrete secreted secretion Serum level Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe COVID-19 severe SARS severe SARS-CoV-2 sialic acid Survivors T cell T cells T-cell TIM-3 Treatment unique viral infection with COVID-19
[DOI] 10.1038/s41423-020-00557-9 PMC 바로가기 [Article Type] Clinical Trial

Application of CareDose 4D combined with Karl 3D technology in the low dose computed tomography for the follow-up of COVID-19

COVID-19 후속 조치를 위한 저선량 컴퓨터 단층 촬영에 Karl 3D 기술과 결합된 CareDose 4D 적용

Research Article

Published on 2020-05-242022-08-07
Journal: BMC Medical Imaging [Category] Fulltext, MERS, SARS, 임상,

[키워드] 5-point double-blind method addition aggravate the disease Apoptosis application axial interstitial thickening blood cell can be used can not CareDose 4D CareDose 4D low-dose scanning caused Chest chest CT examination compared and analyzed Computed tomography consolidation control group coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients crazy-paving pattern CT dose index CT measurement diagnosis and monitoring Diagnostic Criteria diagnostic physician DLP dose dose length product effective effective dose evaluated evaluation criteria fiber cable shadow Follow-up greatly reduce ground glass opacities Image quality Infectious disease interstitial thickening iterative Karl 3D Karl 3D iterative reconstruction technology Karl 3D iterative technique Karl 3D technology low dose low white blood cell counts low-dose low-dose CT method low-dose scanning lung window lymphocyte Lymphocytes Multiple CT examination Multiple CT examinations New coronavirus new low-dose CT method no significant difference noise level occurrence rate patients with COVID-19 Peripheral blood peripheral blood lymphocytes Previous studies previous study radiation damage radiation damages Radiation dose randomly divided reconstructed reduced lymphocyte ratios regular CT Result shown significant difference significant differences Standard deviation statistically study group the study group two group two groups Volume was reduced was used White blood cell
[DOI] 10.1186/s12880-020-00456-5 PMC 바로가기 [Article Type] Research Article