CT-Assessment of Epicardial Fat Identifies Increased Inflammation at the Level of the Left Coronary Circulation in Patients with Atrial FibrillationArticle Published on 2024-02-262024-09-05 Journal: Journal of Clinical Medicine [Category] update2024, [키워드] Atrial fibrillation Coronary computed tomography angiography Fat attenuation index perivascular inflammation [DOI] 10.3390/jcm13051307 PMC 바로가기 [Article Type] Article
The Delta SARS-CoV-2 Variant of Concern Induces Distinct Pathogenic Patterns of Respiratory Disease in K18-hACE2 Transgenic Mice Compared to the Ancestral Strain from WuhanDelta SARS-CoV-2 변종은 우한의 조상 균주와 비교하여 K18-hACE2 형질전환 마우스에서 호흡기 질환의 뚜렷한 병원성 패턴을 유도합니다Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis B cells Brain caused CD45 Cell cells clinical disease concern coronavirus COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines Cytokines Delta delta variant dendritic cell dendritic cells disease dissemination hACE2 help Immune escape immune response Increased Infection infiltration Inflammatory inflammatory monocytes intestinal wall intestine K18-hACE2 K18-hACE2 mice K18-hACE2 transgenic mice kidney lung Lungs manifestation mice Monocytes mouse model multiple tissues no significant difference observation Pathogenesis pathogenicity pattern perivascular inflammation Proinflammatory cytokine proinflammatory cytokines provide respiratory SAME AS SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe COVID-19 shown significant difference significantly lower strain T cells the disease therapeutic intervention therapeutic interventions Therapies tissue damage tissue pathology Transmissibility Treatment strategies two groups variant Wuhan [DOI] 10.1128/mbio.00683-22 PMC 바로가기 [Article Type] Article
Cutaneous leukocytoclastic vasculitis secondary to COVID-19 infection leading to extensive skin necrosisResearch article Published on 2022-03-012022-10-05 Journal: Clinics in dermatology [Category] COVID19(2023년), SARS, 변종, [키워드] Activation complement courses COVID-19 COVID-19 infection Cutaneous death described disease dominant Endotheliitis heterogeneous manifestation Mild Necrosis pandemic pathophysiologic patients with COVID-19 perivascular inflammation polymerase chain reported SARS-CoV-2 survived tissue tissue damage Trigger Vasculitis while [DOI] 10.1016/j.clindermatol.2022.02.013 [Article Type] Research article
Impairing RAGE signaling promotes survival and limits disease pathogenesis following SARS-CoV-2 infection in miceRAGE 신호 전달 장애는 생쥐에서 SARS-CoV-2 감염 후 생존을 촉진하고 질병 발병을 제한합니다Research Article Published on 2022-01-252022-09-10 Journal: JCI Insight [Category] 유전자 메커니즘, 진단, [키워드] CD45 Cell cell death Cellular and molecular mechanisms contribute Critical defined disease pathogenesis driving Efficacy end products endothelial event hyperplasia immunology IMPROVE Infection Infectious disease Inflammation initiated Innate immunity interstitial pneumonia limit lung Lung injury Lungs mediator metabolic mice molecular molecular mechanism morbidity mouse model necrotic necrotic cell death outcome oxygen oxygen saturation Pathogenesis pathology perivascular perivascular inflammation populations promote RAGE receptor receptor for advanced glycation end products replicated SARS-CoV-2 SARS-CoV-2 disease SARS-COV-2 infection Signaling survival therapeutic target Therapeutic treatment tissue injury Treatment triggering Viral viral loads [DOI] 10.1172/jci.insight.155896 PMC 바로가기 [Article Type] Research Article
Infection of Brain Pericytes Underlying Neuropathology of COVID-19 PatientsCOVID-19 환자의 신경 병리학의 기초가 되는 뇌 혈관주위세포의 감염Article Published on 2021-10-272022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, 치료법, [키워드] ACE2 ACE2 expression Blood–brain barrier blood–brain barrier Brain cells Central nervous system cerebrospinal fluid COVID-19 demonstrated dsRNA etiology exhibited expression fibrinogen homeostasis immunostaining indicated individual infected cases Infection Macrophage Macrophage infiltration marker median age moderate multiplexed IHC neurological neurological manifestation neurological manifestations Neurological symptom Neurological symptoms Neuropathology Neurovascular Patient pericyte pericytes perivascular perivascular cells perivascular inflammation receptor ACE2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor significantly lower subset T cell the SARS-CoV-2 Vascular vasculature Viral viral dsRNA virus entry [DOI] 10.3390/ijms222111622 PMC 바로가기 [Article Type] Article
Neuropathology and Inflammatory Cell Characterization in 10 Autoptic COVID-19 BrainsArticle Published on 2021-08-312022-10-31 Journal: Cells [Category] COVID-19, MERS, SARS, [키워드] addition Affect age Brain brain autopsy cause changes characterization Comorbidities COVID-19 COVID-19 patients described Encephalopathy feature Hemorrhagic highlighting hypoxic Infection Inflammation Injury knowledge Laboratory safety lesion macrophages microvascular injury nervous system neurological manifestations Neurological symptoms neuronal Neuropathology Patient perivascular inflammation Post-mortem SARS-CoV-2 SARS-COV-2 infection Support surviving patient T cell Vascular [DOI] 10.3390/cells10092262 PMC 바로가기 [Article Type] Article
Endothelial cell infection and dysfunction, immune activation in severe COVID-19내피 세포 감염 및 기능 장애, 심한 Covid-19에서의 면역 활성화Research Paper Published on 2021-07-062022-09-10 Journal: Theranostics [Category] MERS, SARS, 진단, 치료기술, [키워드] Activation adhesion alveolar septa animals body weight Body weight loss Brain infection cadherin cause Cell circulation Coagulation collected complement conducted contribute correlated COVID-19 COVID-19 disease COVID-19 patients cytokine Deceased develop downregulation dysfunction edema electron microscopy endothelial Endothelial cell endothelial cells Endotheliitis Eosinopenia epithelial cells evidenced fatality hemorrhage ICAM1 immune activation Immune cell immune cells immunostaining infect Infection initial Injury interstitial inflammation K18 K18-hACE2 lung Lung epithelial cells Lungs lymphocytopenia mice Microscopy NHP NHP models organ organs Pathogenesis pathway Pathways Patient perivascular inflammation Platelet Platelets Pneumonia pulmonary PULMONARY VESSELS rationale Result RNA-seq analyses SARS-CoV-2 SARS-COV-2 infection serum severe COVID-19 severe COVID-19 disease severity Signaling Single Cell up-regulation upregulated Vascular VCAM1 VE-cadherin vessel weight loss while [DOI] 10.7150/thno.61810 PMC 바로가기 [Article Type] Research Paper
Lesions in the lungs of fatal corona virus disease Covid-19Review Published on 2021-03-012023-07-13 Journal: Ann Anat [Category] SARS, [키워드] Angiogenesis COVID-19 Diffuse alveolar damage hyaline membranes lung lesions pathology perivascular inflammation SARS-CoV-2 thrombi [DOI] 10.1016/j.aanat.2020.151657 PMC 바로가기 [Article Type] Review
Enhanced inflammation in New Zealand white rabbits when MERS-CoV reinfection occurs in the absence of neutralizing antibodyResearch Article Published on 2017-08-172022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] absence accompanied acute respiratory disease antibody Asymptomatic case asymptomatic infection Betacoronavirus Clinical signs complement confirmed case Contact tracing deaths develop dose-dependent elicited enhanced Human implication increase in individual Infection Inflammation Inflammatory response inoculated intranasal Lung disease Lung inflammation lung lobe MERS-CoV Middle East Mild naïve Neutralizing activity neutralizing antibody Neutralizing antibody response Neutralizing antibody titer New non-neutralizing antibody occur perivascular inflammation Primary infection PROTECT Protein Proteins Pulmonary infection pulmonary inflammation recruitment Reinfection reported respiratory syndrome coronavirus risk serum subsequent transfer Viral antigen viral challenge Viral protein Viral RNA waned while zoonotic [DOI] 10.1371/journal.ppat.1006565 PMC 바로가기 [Article Type] Research Article