Egr-1 is a key regulator of the blood-brain barrier damage induced by meningitic Escherichia coliResearch Published on 2024-01-172024-09-05 Journal: Cell Communication and Signaling : CCS [Category] update2024, [키워드] blood-brain barrier early growth response 1 Meningitic E. Coli Neuroinflammation permeability [DOI] 10.1186/s12964-024-01488-y PMC 바로가기 [Article Type] Research
Durable antibody and effector memory T cell responses in breastmilk from women with SARS-CoV-2Article Published on 2022-09-122022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] antibody asked B.1.1.7 B.1.351 Beta binding Blood breast milk breast permeability breastmilk CCR7 CD4 CD45RO CD8 T cell Cell complex COVID-19 COVID-19 vaccine D614G domain dried blood spot effector memory elect enrolled expressed first COVID-19 symptom flow cytometry Gamma IgA IgA response IgG IgM Immunity Immunoglobulin indicated Infant lactating memory memory T memory T cells milk mother mucosal mucosal immunity neutralize neutralized Neutralizing P.1 participant passive immunity permeability positive potassium ion pregnant women Protective reactivity receive robust SARS-CoV-2 SARS-COV-2 infection second set significantly higher sodium Stool T cell T cell response tested the spike protein timepoint was collected were assessed women [DOI] 10.3389/fimmu.2022.985226 PMC 바로가기
SARS-CoV-2 productively infects human brain microvascular endothelial cellsArticle Published on 2022-06-152023-07-09 Journal: Journal of Neuroinflammation [Category] COVID19(2023년), [키워드] Blood–brain barrier human brain microvascular endothelial cells Inflammatory response permeability SARS-CoV-2 [DOI] 10.1186/s12974-022-02514-x PMC 바로가기
Potential of antiviral peptide-based SARS-CoV-2 inactivators to combat COVID-19COVID-19 퇴치를 위한 항바이러스 펩티드 기반 SARS-CoV-2 불활성화제의 가능성Article Published on 2022-06-032022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-SARS-CoV-2 Antiviral antiviral drug antiviral drugs antiviral therapeutics appearance binding binding energy can be used Candidates caused Cell cells complexes conformational change conformational changes coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 effective Effectiveness enzyme evidenced experiment geometric host cells host receptor hydrogen Hydrogen bond hydrogen bonds hydrophobic hydrophobic interactions identify inactivation increase in induce infecting Infectious disease lack membrane fusion molecular molecular dynamics MOST non-toxic peptide peptide-based peptides permeability Potential Protein SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus solvent Spike protein stability surface area target the spike protein Therapies Treatment Vaccine variant viral cell Virtual screening virus water [DOI] 10.1371/journal.pone.0268919 PMC 바로가기 [Article Type] Article
A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies투과성 연구에서 나노제형을 사용하여 적용된 COVID-19 약물 몰누피라비르의 측정을 위한 안정성을 나타내는 RP-HPLC 방법Article Published on 2022-05-302022-09-11 Journal: Journal of pharmaceutical and biomedical analysis [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 antiviral drugs applied Caco-2 calculated candidate cell line column conditions Coronavirus-2 Council COVID-19 demonstrated drug drug candidate drug delivery system flow rate homogeneity ICH in vitro Infection linear molnupiravir N4-hydroxycytidine nucleoside optimization oxidative stress pandemic peak permeability prodrug quantitation robust RP-HPLC SARS-CoV-2 SARS-CoV-2 treatment selective Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus specificity stability validation was performed was used water [DOI] 10.1016/j.jpba.2022.114693 PMC 바로가기 [Article Type] Article
Safety and preliminary efficacy of sequential multiple ascending doses of solnatide to treat pulmonary permeability edema in patients with moderate to severe ARDS in a randomized, placebo-controlled, double-blind trial: preliminary evaluation of safety and feasibility in light of the COVID-19 pandemicRandomized Controlled Trial Published on 2022-04-042022-10-05 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] activity Alter ARDS ARDS patient Ascending baseline causes Clinical characteristics clinical study clinical trial conducted COVID-19 COVID-19 ARDS patient COVID-19 pandemic COVID-19 patient doses double-blind DSMB edema Efficacy enrolled Enrollment Evidence exceptional feasibility groups indication interim analysis investigator less mandatory Multiple multiple ascending dose noradrenaline not differ observation period outcome Oxygenation pandemic parameter Patient patients with moderate permeability phase IIB placebo-controlled pulmonary Pulmonary edema pulmonary permeability Randomized required risk Safety Safety Monitoring Board SARS-CoV-2 Sepsis severe ARDS sick Solnatide Study design survival rate treat Trial Ventilation [DOI] 10.1186/s13063-022-06182-3 PMC 바로가기 [Article Type] Randomized Controlled Trial
Multiscale Model of Antiviral Timing, Potency, and Heterogeneity Effects on an Epithelial Tissue Patch Infected by SARS-CoV-2SARS-CoV-2에 감염된 상피 조직 패치에 대한 항바이러스 타이밍, 효능 및 이질성 효과의 다중 스케일 모델Article Published on 2022-03-142022-09-11 Journal: Viruses [Category] SARS, 치료제, [키워드] Affect agent agent-based model Antiviral antiviral therapies antiviral therapy Cell cell-to-cell variability cellular cellular metabolism cellular uptake dosage dose Effect Efficacy epithelial Epithelial Tissue Frequency homogeneous include Infection likelihood lowest lung tissue metabolism metabolite Model mPBPK multiscale model outcome outcomes parameters patch permeability pharmacokinetic potency predict Remdesivir SARS-CoV-2 significantly Super-spreader tissue tissue model treat Treatment treatment initiation Treatment outcome Variability Variation viral infection viral infections virtual tissue simulation. [DOI] 10.3390/v14030605 PMC 바로가기 [Article Type] Article
The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signalingSARS-CoV-2의 스파이크 단백질은 인테그린 α5β1 및 NF-κB 신호 전달을 통해 내피 염증을 유도합니다Article Published on 2022-03-012022-09-11 Journal: The Journal of Biological Chemistry [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 activate Activation addition adhesion Adhesion Molecule administration bind Blood Capillaries CD45 Coagulation coagulation factor Coagulation factors COVID-19 Critical Cytokines dependent on domain dysfunction dysregulated edema Effects endothelial Endothelial cell endothelial cells Endothelial dysfunction expression FVIII hallmark hallmarks homeostasis ICAM1 IL-1β IL-6 in vivo increased expression Incubation induce Inflammation inflammatory phenotype inhibitor inhibitors integrin intravenous Intravenous administration intravitreal injection kidney leukocyte leukocytes liver lung maintain mechanism motif NF-κB NF-κB signaling nuclear translocation occur Peripheral blood peripheral blood leukocyte peripheral blood leukocytes permeability prevented Proinflammatory cytokine proinflammatory cytokines Receptor-binding domain responsible SARS-CoV-2 severe disease Signaling Spike protein spike protein of SARS-CoV-2 subsequent target gene the receptor-binding domain the spike protein tissue tissues TNFα umbilical umbilical vein vascular effect vascular endothelial cells vascular inflammation vascular leakage VCAM1 [DOI] 10.1016/j.jbc.2022.101695 PMC 바로가기 [Article Type] Article
Elevated Cytokine Levels in Plasma of Patients with SARS-CoV-2 Do Not Contribute to Pulmonary Microvascular Endothelial PermeabilitySARS-CoV-2 환자의 혈장에서 증가된 사이토카인 수준은 폐 미세혈관 내피 투과성에 기여하지 않습니다Research Article Published on 2022-02-162022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, [키워드] accounted ACE-2 receptor ACE2 antibody acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute SARS-CoV-2 infection angiopoietin antagonists antiinflammatory cytokines appear approach ARDS barrier dysfunction C3a C5a cause Cell changes in circulating Combination complement complements factors consecutive patient Control controls coronavirus cytokine Cytokines death demonstrated determine disrupt Effect eight Elevation endothelial Endothelial cell endothelial injury endothelial permeability enrolled evaluated Evidence evidence of Frequency greater growth factor heat inactivation human lung in vitro infections inhibitors labile Level lung magnitude mechanism Microvascular damage morbidity morbidity and mortality multiorgan failure Neutralizing antibodies neutralizing antibody occur patients patients hospitalized patients with SARS-CoV-2 permeability plasma positive control predicted produced proinflammatory cytokines provide pulmonary receptor receptor antagonists respiratory respiratory distress SARS-CoV-2 SARS-CoV-2 infected patients SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 patient SARS-CoV-2 patients SARS-CoV-2 plasma selected severe acute respiratory syndrome Coronavirus severe complication severe complications Spike protein subsequent susceptible syndrome the SARS-CoV-2 thrombin TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-alpha Variability Vascular vascular endothelial growth factor Vascular injury vascular permeability VEGF [DOI] 10.1128/spectrum.01671-21 PMC 바로가기 [Article Type] Research Article
Penetration of the SARS-CoV-2 Spike Protein across the Blood–Brain Barrier, as Revealed by a Combination of a Human Cell Culture Model System and Optical BiosensingArticle Published on 2022-01-172022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] barrier biosensor Brain Caco-2 cells caused cell layer circulation consequence coronavirus spike protein cross demonstrated disseminate ELISAs Endothelial cell evaluate global pandemic Human human brain endothelial cell in vitro Infection Integrated optics intestinal investigated Mach–Zehnder interferometer mechanism mice Model model system Neuroinflammation Neuroinvasive Neurological symptom observation optical organ outbreak penetration permeability Respiratory Coronavirus Respiratory system Revealed route of infection SARS-CoV-2 spike Spike protein System the disease the S1 subunit the SARS-CoV-2 tissue barriers viral spike protein [DOI] 10.3390/biomedicines10010188 PMC 바로가기 [Article Type] Article